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    Glossary DDB1 and CUL4 associated factor 17

    protein involved in tagging unwanted proteins for degradation

    DDB1 and CUL4 associated factor 17, also known as DCAF17, is a protein that plays a role in the regulation of cellular processes by participating in the ubiquitin-proteasome system, which tags unwanted proteins for degradation. Mutations in the DCAF17 gene have been linked to certain forms of alopecia, a condition characterized by hair loss, highlighting its importance in hair follicle biology and maintenance.

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    Research 23

    1. To grow or not to grow: Hair morphogenesis and human genetic hair disorders Seminars in Cell & Developmental Biology · 2013 · 43 citations
    2. Hair Growth-Promoting effect of the coffee bean residue extract on hair follicle dermal papilla cells via the activation of autophagy Journal of functional foods · 2024
    3. Novel splicing‐site mutation in <i>DCAF17</i> gene causing Woodhouse‐Sakati syndrome in a large consanguineous family Journal of clinical laboratory analysis · 2021 · 4 citations
    4. Genomic prediction and genome-wide association studies of morphological traits and distraction index in Korean Sapsaree dogs PLoS ONE · 2024 · 2 citations
    5. Woodhouse-Sakati syndrome: genotype–phenotype review and case of intra-familial heterogeneity Journal of Rare Diseases · 2024
    6. Woodhouse-Sakati Syndrome Due to the Rare DCAF17 c.321+1G>A Mutation: The Second Case Report Worldwide Cureus · 2026
    7. FOXP3 <sup>+</sup> regulatory T cells and age‐related diseases FEBS Journal · 2021 · 26 citations
    8. Expanding on the phenotypic spectrum of Woodhouse‐Sakati syndrome due to founder pathogenic variant in <i>DCAF17</i>: Report of 58 additional patients from Qatar and literature review American Journal of Medical Genetics Part A · 2021 · 10 citations
    9. Case Report: A Deletion Variant in the DCAF17 Gene Underlying Woodhouse-Sakati Syndrome in a Chinese Consanguineous Family Frontiers in genetics · 2021 · 1 citations
    10. PROTACs: A novel strategy for cancer drug discovery and development MedComm · 2023 · 44 citations
    11. Advancing Design Strategy of PROTACs for Cancer Therapy MedComm · 2025 · 4 citations
    12. Tissue-Specific Multi-Omics Integration Demonstrates Molecular Signatures Connecting Obesity to Immune Vulnerability Metabolites · 2026
    13. Protein degradation: expanding the toolbox to restrain cancer drug resistance Journal of Hematology & Oncology · 2023 · 7 citations
    14. Writer’s Cramp Presentation of Woodhouse–Sakati Syndrome – “Out of the Woods” Canadian journal of neurological sciences · 2021 · 1 citations
    15. Replicative stress, stem cells and aging Mechanisms of Ageing and Development · 2008 · 70 citations
    16. Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism Journal of Investigative Dermatology · 2008 · 51 citations
    17. Evaluation of Personalized Skincare Through in-silico Gene Interactive Networks and Cellular Responses to UVR and Oxidative Stress Clinical Cosmetic and Investigational Dermatology · 2022 · 11 citations
    18. Ligand‐Independent Actions of the Vitamin D Receptor: More Questions Than Answers JBMR plus · 2021 · 11 citations
    19. Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One Journal of Medicinal Chemistry · 2022 · 10 citations
    20. Human Pigmentation: A Review of Molecular Mechanisms, Genetic Architecture, Evolution, Forensic DNA Phenotyping and Health Implications Journal of Genome Biotechnology and Genetics · 2026
    21. Molecular Morbidity Score–Can MicroRNAs Assess the Burden of Disease? International Journal of Molecular Sciences · 2024
    22. Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness Animals · 2023
    23. Table_1_Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea.xlsx OPAL (Open@LaTrobe) (La Trobe University) · 2021