October 2022 in “Amplla Editora eBooks” Deep Brain Stimulation helps manage Parkinson's symptoms when medication isn't enough.
October 2022 in “Amplla Editora eBooks” Traumatic brain injury hospitalizations in Brazil showed specific trends and patterns from 2008 to 2021.
Vitamin D is crucial for skin health and managing skin diseases.
April 2022 in “Brazilian Medical Students” This review synthesizes existing evidence on the link between androgenic alopecia and severe COVID-19 outcomes, noting a potential role for anti-androgenic therapies in treating SARS-CoV-2 infections.
December 2021 in “Revista da Sociedade Portuguesa de Dermatologia e Venereologia” This review discusses the impact of dysbiosis on scalp diseases like seborrheic dermatitis and alopecia areata, reporting no new results; the authors suggest the microbiome could offer therapeutic options.
October 2021 in “Interfaces Científicas” This study analyzed the nutritional composition of 75 nutricosmetic products, finding common ingredients like biotin and zinc, but emphasized the need for further research on their effectiveness for hair and nail health.
October 2021 in “Open Repository of the University of Porto (University of Porto)” This study conducted a literature review and found that intradermotherapy, a minimally invasive technique involving needle punctures and drugs like minoxidil and finasteride, appears to be safe and effective for short-term treatment of alopecia, with satisfactory results and no significant side effects.
February 2021 in “Open Repository of the University of Porto (University of Porto)”
In this study, researchers found that cosmetic formulations containing guaraná extract effectively controlled oiliness in oily skin and hair by reducing sebaceous gland activity and lipid content without compromising skin barrier function, making them promising for managing excessive sebum production.
May 2020 in “riUfes (Universidade Federal do Espírito Santo)” This study found that finasteride is stable under various stress conditions except for basic hydrolysis at extreme pH levels and identified compatible and incompatible excipients in pharmaceutical formulations, suggesting formulation changes for increased safety.
January 2020 in “Surgical and Cosmetic Dermatology” This study found that a topical hair ampoule containing human follicle stem cells significantly improved hair growth and scalp coverage in women with androgenetic alopecia after four months of use.
This study found that the ethanolic extract of Guazuma ulmifolia, or mutamba, showed only intermediate levels of phenolic compounds and low antioxidant activity in laboratory tests, suggesting limited potential in alleviating oxidative stress conditions like cancer or cardiovascular diseases.
January 2019 in “Revista Medicina Cutánea Ibero-Latino-Americana” This article reviews the influence of vitamin D on various dermatological diseases and suggests that vitamin D supplementation might aid in maintaining skin cell homeostasis; it reports no new clinical results.
In this study, a clear pattern of selective sweep was observed for the SLC24A5 gene, with high linkage disequilibrium and low haplotype diversity, but no clear correlation with UV radiation intensity was found.
August 2015 in “Arquivo Brasileiro de Medicina Veterinária e Zootecnia/Arquivo brasileiro de medicina veterinária e zootecnia” This study found that maternal caffeine intake during gestation and lactation can lead to skin lesions like hypotrichosis and alopecia in both mother and offspring rats, irrespective of maternal cortisol levels.
This review suggests that finasteride at 1 mg/day reduces PSA levels similarly to 5 mg/day, but differences in prostate dihydrotestosterone levels may affect prostate cancer diagnosis and prevention.
January 2014 in “Surgical and Cosmetic Dermatology” This study found that nutritional supplementation improved hair loss in women with telogen effluvium, showing a significant increase in anagen hairs and reduction in telogen hairs after three months.
July 2013 in “Revista da Universidade Vale do Rio Verde” In this study on short-term flutamide treatment in mice, no significant changes were observed in estrous cycle phases, but further research is needed to explore potential reproductive effects.
February 2013 in “Americanae (AECID Library)” In this study, finasteride exposure in human prostatic cell lines did not affect cell proliferation but significantly reduced MMP activity and increased TIMP expression, potentially inhibiting tumor cell invasion and metastasis.
This study found that in rats, combined treatment with finasteride and doxazosin altered epithelial cell behavior and matrix metalloproteinases activity, suggesting effects possibly mediated by TGF-β1 and androgen pathways.
In this study, no significant difference was found between the efficacy of betamethasone dipropionate cream and placebo in treating alopecia areata in children, regardless of atopic status.
April 2023 in “Zenodo (CERN European Organization for Nuclear Research)” This article discusses the effects of 1mg/day finasteride on PSA levels and its implications for prostate cancer diagnosis, reporting no new clinical results; further investigation is suggested.
510 citations
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August 2006 in “Endocrinology” This minireview discusses a proposed model of the vitamin D receptor that explains how 1alpha,25(OH)2D3 can mediate both genomic and rapid responses through different ligand shapes and cellular locations, without presenting new research findings.
378 citations
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February 2020 in “Nature Reviews Endocrinology”
119 citations
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July 2016 in “Annals of the New York Academy of Sciences” This review examines the impact of vitamin D signaling in extraskeletal tissues and notes that expected benefits from animal and cell studies have not been consistently replicated in human clinical trials.
57 citations
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April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the vitamin D receptor is crucial for initiating the postnatal hair follicular cycle in mice, preventing alopecia associated with its inactivation.
37 citations
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October 2021 in “Nutrients” This study discusses the potential association between low vitamin D levels and insulin resistance, suggesting that vitamin D deficiency may contribute to disorders like obesity and diabetes, but emphasizes the need for further research to confirm these links.