153 citations
,
April 1998 in “Current Biology” This study found that benign tumors with a high risk of malignant progression primarily arise from hair follicle cells when a mutant ras gene is expressed in a specific population of epidermal cells in mice.
114 citations
,
January 2016 in “Current topics in developmental biology/Current Topics in Developmental Biology” This review discusses the diverse roles of Frizzled proteins in developmental and homeostatic processes and reports no new experimental findings.
102 citations
,
October 2010 in “Molecular Pharmaceutics” In this study, copper-doxorubicin liposomes with multidose therapy reduced systemic toxicity compared to ammonium sulfate-loaded doxorubicin liposomes, while combinatorial strategies further enhanced tumor regression and accumulation.
48 citations
,
March 2020 in “Stem Cell Research & Therapy” This study found that human adipose-derived stem cells co-cultured on a collagen sponge scaffold showed increased differentiation into keratinocytes, suggesting potential for improved skin wound healing.
182 citations
,
December 2021 in “Cosmetics” This literature review discusses recent advances in using essential oils and their components in cosmetic products, highlighting their diverse benefits and challenges in formulation due to varying chemical profiles, as well as addressing safety considerations for these natural ingredients.
115 citations
,
August 2020 in “International Journal of Molecular Sciences” This systematic review indicates that a platelet-rich plasma concentration of 1.0 × 10^6 plt/μL may be optimal for tissue regeneration due to sufficient nutrition supply and effective growth factor diffusion in vivo.
30 citations
,
November 2015 in “Advanced Pharmaceutical Bulletin” This study found that nanoethosomes containing Lidocaine showed effective skin penetration, suggesting they may be a suitable carrier for topical anesthetic delivery.
1 citations
,
November 2025 in “Molecules” This review highlights the potential of ellagic acid for treating various skin conditions due to its antioxidant, anti-inflammatory, and depigmenting properties, but notes that novel formulations are needed to overcome its poor solubility and skin permeability to enhance clinical efficacy.
May 2025 in “American Journal of Veterinary Research” Photobiomodulation did not significantly improve hair density in dogs with alopecia X.
July 2024 in “Pharmaceutics” In a mouse model of androgenetic alopecia, this study found that a novel hydrogel containing minoxidil-incorporated engineered exosomes (Gel@MNs) enhanced hair regeneration more effectively than conventional minoxidil, increasing hair follicle number and size while reducing skin irritation.
11 citations
,
January 2017 in “Evidence-based Complementary and Alternative Medicine” This study investigated the effects of the herbal formulation DA-5512 on hair growth, finding that it significantly promotes dermal papilla cell proliferation and stimulates hair growth in mice while showing efficacy and safety in human trials compared to placebo and minoxidil (3%).
January 2006 in “FarFar - Pharmacy Repository” This paper reviews cosmetic active substances for treating pregnancy-related skin changes like hyperpigmentation and striae, discussing their efficacy and safety but reports no new clinical results.
81 citations
,
March 1985 in “Journal of Clinical Investigation” This study found that measuring 24-OHase induction by 1,25(OH)2D3 in cultured skin fibroblasts is a sensitive test for detecting genetic defects in the 1,25(OH)2D effector pathway.
October 2025 in “International Journal of Reproduction Contraception Obstetrics and Gynecology” This study found that Myoinositol and D-chiro inositol treatment improved fertility outcomes in women with PCOS, particularly in Phenotypes A and D, but larger studies are needed to confirm these results.
1308 citations
,
March 1998 in “Journal of bone and mineral research” This review discusses the molecular role of the vitamin D receptor in regulating various biological actions such as bone mineralization and reports no new clinical results, highlighting the complexity of vitamin D's function in multiple tissues.
114 citations
,
October 2017 in “American journal of clinical dermatology” Adequate vitamin D is crucial for skin health and should be considered in dermatology.
71 citations
,
July 2018 in “Revista do Colégio Brasileiro de Cirurgiões” This study found that bariatric surgery effectively treated morbid obesity and improved quality of life and the resolution of comorbidities for most patients.
48 citations
,
January 2015 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses the various roles of vitamin D in skin disorders, including established use in psoriasis and potential applications for atopic dermatitis and skin cancer prevention, but reports no new clinical results.
47 citations
,
September 2023 in “Pharmacological Reports” In this review, researchers explored the roles of vitamins A, B3, C, D, and E in skin immunity, highlighting their potential as therapeutics for skin diseases due to their antioxidant, anti-inflammatory, and antimicrobial properties.
18 citations
,
September 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that vitamin D-upregulated protein 1 (VDUP1) might play a unique role in regulating the differentiation of epidermal cells.
13 citations
,
April 2019 in “Actas Dermo-Sifiliográficas” This review discusses the relationship between vitamin D and various skin diseases, highlighting recent findings on its role and the importance of assessing and correcting vitamin D levels, but reports no new clinical results.
13 citations
,
December 2012 in “Frontiers in bioscience” This review discusses the potential role of vitamin D deficiency in cardiovascular and renal diseases and suggests that supplemental vitamin D could benefit cardiovascular outcomes, especially in African American and postmenopausal women; it reports no new clinical findings.
6 citations
,
August 2020 in “Dermatology and Therapy” This study found that patients with alopecia areata had significantly lower serum vitamin D levels and higher odds of vitamin D deficiency, but no significant difference in serum calcium levels, compared to controls.
6 citations
,
February 2003 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This study found no significant difference in the effectiveness of betamethasone dipropionate cream compared to placebo for treating alopecia areata in children, and atopic status did not influence treatment response.
1 citations
,
April 2025 in “Revista científica FACS.” This study explored the potential use of natural ingredients in managing alopecia areata, investigating their safety and efficacy as alternatives to conventional chemical treatments.
1 citations
,
February 2025 in “Frontiers in Endocrinology” In this study, researchers observed that dietary vitamin D intake and light exposure play a crucial role in vitamin D metabolism in mice, suggesting similar importance for human health in maintaining optimal vitamin D levels.
1 citations
,
November 2024 in “Revista JRG de Estudos Acadêmicos” This review discusses available treatments for androgenetic alopecia and highlights that, although no definitive treatment exists, current options generally achieve high satisfaction rates.
1 citations
,
May 2023 in “Revista Eletrônica Acervo Saúde” In this study, researchers reported that individuals with post-COVID-19 alopecia experienced a significant impact on their quality of life, particularly in the vitality domain, when compared to those without alopecia.
1 citations
,
December 2018 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” This study found that combining electrotherapy with aromatherapy led to increased hair shaft thickness in men with androgenetic alopecia, although no changes in the scalp were observed.
1 citations
,
June 2012 in “Revista Brasileira de Cirurgia Plástica” In this study, the authors reported that frontal rhytidectomy with a pre-hairline incision effectively reduces a long forehead in select patients, with patients feeling the benefits outweighed the visibility of the scar.