research The Post-Finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption
Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.
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research Probiotic Bacteria Induce a Glow of Health
Probiotic bacteria improved skin and hair health in aged mice.
research Sexual Dysfunction in Subjects Treated with Inhibitors of 5α-Reductase for Benign Prostatic Hyperplasia: A Comprehensive Review and Meta-Analysis
Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.
research Alisertib Is Active as Single Agent in Recurrent Atypical Teratoid Rhabdoid Tumors in Four Children
Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.
research Chemical Profiling and Quantitation of Bioactive Compounds in Platycladi Cacumen by UPLC-Q-TOF-MS/MS and UPLC-DAD
Researchers identified new compounds in Platycladi Cacumen and found variations in its flavonoid content, which could aid in its quality control.
research Post-Finasteride Syndrome and Post-SSRI Sexual Dysfunction: Two Sides of the Same Coin?
PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.
research Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition
Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.
research The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation
The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.
research The 5α-Reductase Inhibitor Dutasteride but Not Finasteride Protects Dopamine Neurons in the MPTP Mouse Model of Parkinson’s Disease
Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.
research Post-Finasteride Syndrome: Risks and Side Effects of Finasteride for Androgenetic Alopecia
Finasteride may cause lasting sexual, mental, and physical symptoms; use with caution.
research Estimation Methods for Human Circadian Phase Using Peripheral Tissues
New method uses hair follicle cells to estimate human body clock phase, potentially improving sleep disorder diagnosis.
research A Rapid Method for Obtaining Finasteride, a 5α-Reductase Inhibitor, from Commercial Tablets
Quickly get finasteride from tablets using easy methods.
research Compilation of a Comprehensive Gene Panel for Systematic Assessment of Genes That Govern an Individual’s Drug Responses
Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.
research Chemical Fingerprint and Quantitative Analysis for the Quality Evaluation of Platycladi Cacumen by Ultra-Performance Liquid Chromatography Coupled with Hierarchical Cluster Analysis
The new method is rapid, sensitive, and accurate for evaluating the quality of the medicinal herb Platycladi cacumen.
research Pediatric Bipolar Disorder: Evidence-Based Psychopharmacological Treatments
Combining mood stabilizers with antipsychotics is more effective for treating children with bipolar disorder than using mood stabilizers alone.
research Sexual Dimorphism Following In Vitro Ischemia in the Response to Neurosteroids and Mechanisms of Injury
Male tissue has more cell death than female tissue after ischemia, and some neurosteroids only protect female cells.
research Finasteride and Suicide: A Postmarketing Case Series
Finasteride may increase suicide risk; more research needed.
research Effects of Chronic Inhibition of Testosterone Metabolism on Cardiac Remodeling After Ischemia/Reperfusion-Induced Myocardial Damage in Gonadectomized Rats
Testosterone reduces heart damage and inflammation after injury.
research Association Between 5-Alpha Reductase Inhibitor Use and the Risk of Depression: A Meta-Analysis
Using 5-alpha reductase inhibitors may increase the risk of mild depression.
research Caraway, Chinese Chives, and Cassia as Functional Foods Considering Nutrients and Health Benefits
Caraway, Chinese chives, and cassia may improve health and prevent diseases due to their nutrients and medicinal properties.
research Crystal Structure of Steroid Reductase SRD5A Reveals Conserved Steroid Reduction Mechanism
The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.
research Dermatological Drugs, Topical Agents, and Cosmetics
Tretinoin gel is safe for sun exposure, but tacalcitol doesn't significantly improve non-segmental vitiligo.
research Reporting on Adverse Clinical Events
Certain medications can reduce mortality risk in COPD patients, but others can increase risks of cardiovascular issues, postoperative delirium, and other adverse effects.
research Subcellular Localization of the Five Members of the Human Steroid 5α-Reductase Family
All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.
research FLCN, A Novel Autophagy Component, Interacts With GABARAP And Is Regulated By ULK1 Phosphorylation
The protein FLCN is involved in cellular cleanup and is regulated by ULK1.
research Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells
Allopregnanolone changes gene expression in glioblastoma cells.
research 5α-Reductases in Human Physiology: An Unfolding Story
We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
research 5α-Reductases in Human Physiology: An Unfolding Story
Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.
research New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-Depth Review of the Literature
There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.
research Hirsutism: A Comprehensive Update of Embryology, Aetiopathogenesis, and Therapeutic Approach
The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.