research TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons
TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.
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research Multifunctional Merkel Cells: Their Roles in Electromagnetic Reception, Fingerprint Formation, Reiki, Epigenetic Inheritance, and Hair Form
Merkel cells may have roles in sensing magnetic fields, creating fingerprints, Reiki energy healing, passing on environmental information to offspring, and influencing hair shape.
research Insights Gained from Chickens' Rapid Hair Development During Hatching Lead to Discovery of Hair Growth Peptide Derived from Egg Yolk
Researchers found a substance in chicken egg yolk that helps hair grow.
research STIM1, But Not STIM2, Is the Calcium Sensor Critical for Sweat Secretion
STIM1 is essential for sweat secretion.
research Blood Plasma Levels of Heart Disease Biomarker Cardiac Troponin I Are Significantly Increased in Alopecia Areata Affected Individuals
People with alopecia areata have higher levels of a heart disease marker in their blood.
research Disturbed Sebum and Microbiome Composition in Sensitive Scalp
Sensitive scalp has higher pH, more redness, abnormal sebum, and altered bacterial makeup.
research External Light Activates Hair Follicle Stem Cells Through Eyes Via the ipRGC-SCN-Sympathetic Neural Circuit
Light can activate hair growth through a pathway from the eyes to hair follicles.
research Air Pollution and Skin Diseases: Adverse Effects of Airborne Particulate Matter on Various Skin Conditions
Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.
research Tumor Regression Predicts Higher Risk of Sentinel Node Involvement in Thin Cutaneous Melanomas
Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.
research The Regeneration Blastema of Lizards: An Amniote Model for the Study of Appendage Replacement
Lizards can regrow their tails, and studying this process helps understand scar-free healing and limb regeneration.
research Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs
Melatonin helps Cashmere goats grow more hair by affecting certain genes and cell pathways.
research A Model System for Long-Term Serum-Free Suspension Organ Culture of Human Fetal Tissues: Experiments on Digits and Skin from Multiple Body Regions
Scientists developed a method to grow human fetal skin and digits in a lab for 3-4 weeks, which could help study skin features and understand genetic interactions in tissue formation.
research The Epidermal Vitamin D System and Innate Immunity: Some More Light Shed on This Unique Photoendocrine System?
Vitamin D made by the skin plays a role in immune defense and skin health, and more research is needed to understand its full effects.
research Wound-Induced Hair Neogenesis: A Novel Paradigm for Studying Regeneration and Aging
Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.
research Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair-Follicle-Derived Stem Cells to Differentiate into Neurons and Glia
Blue-light activation of TrkA improves hair-follicle stem cells' ability to become neurons and glial cells.
research Skin Biology
Current therapies cannot fully regenerate adult skin without scars; more research is needed for scar-free healing.
research A Role for Steroid 5 Alpha-Reductase 1 in Vascular Remodeling During Endometrial Decidualization
The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.
research The Influence of Flightless I: Regeneration Versus Wound Healing
Blocking RANK signaling might help treat metastatic melanoma, but more research is needed.
research A Role for Steroid 5 Alpha-Reductase 1 in Vascular Remodeling During Endometrial Decidualization
The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.
research Ayurveda-Based Botanicals as Therapeutic Adjuvants in Paclitaxel-Induced Myelosuppression
Asparagus racemosus and Withania somnifera can help reduce side effects of a cancer drug.
research Efficacy of Dupilumab in Treating Atopic Dermatitis With Recurrent Eczema Herpeticum in a Patient With DOCK8-Deficiency Hyper-IgE Syndrome: A Case Report
Dupilumab helped improve skin and prevent new lesions in a child with a rare immune disorder and severe eczema.
research MTORC1 Activity Negatively Regulates Human Hair Follicle Growth and Pigmentation
High mTORC1 activity slows hair growth and causes it to lose color.
research The Use of Auto-Antibody Testing in the Evaluation of Interstitial Lung Disease: A Practical Approach for the Pulmonologist
Auto-antibody testing is a useful but not definitive tool in diagnosing interstitial lung diseases, and using a specific algorithm could make testing more cost-effective.
research Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging
Older mice have stiffer skin with less elasticity due to changes in collagen and skin structure, affecting aging and hair loss.
research Optical Coherence Tomography Angiography Findings in Polycystic Ovary Syndrome
Women with PCOS have thicker parafoveal areas in their retinas, but their macular blood vessel density is normal.
research Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis
The stiffness of a wound affects hair growth during healing, with less stiff areas growing more hair.
research Erythrocyte Deformability and Hereditary Elliptocytosis
Hereditary elliptocytosis causes elongated red blood cells and can lead to mild or no symptoms.
research Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment
The study demonstrated that Myc activation in mouse epidermis led to the depletion of the epidermal stem cell compartment by altering adhesive interactions with the local microenvironment. This was evidenced by the transcriptional analysis of over 10,000 genes, revealing that Myc activation induced genes related to RNA and protein synthesis, cell proliferation, and differentiation, while downregulating over 40% of genes associated with cell adhesion and cytoskeleton proteins. These changes impaired keratinocyte adhesion, motility, and wound healing, correlating with decreased expression of extracellular matrix proteins and integrins, and reduced formation of hemidesmosomes and actomyosin cytoskeleton assembly. Consequently, Myc activation prompted stem cell exit and differentiation into sebocytes and interfollicular epidermis at the expense of hair lineages, due to impaired keratinocyte migration necessary for hair differentiation.
research Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration
Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.
research Effects of Aromatase Inhibitors on Human Osteoblast and Osteoblast-Like Cells: A Possible Androgenic Bone Protective Effect Induced by Exemestane
Exemestane may protect bones by stimulating osteoblast growth through androgen-related pathways.