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Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

Early detection and intensive treatment of diseases caused by Staphylococcus aureus toxins are crucial for reducing severe health effects.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Rhodococcus equi causes severe pneumonia in young foals, and effective vaccines are needed due to foals' weak immune responses.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

Stress increases nerve fibers and immune cell activity in mouse skin, possibly worsening skin conditions.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.

The yeast Pityrosporum ovale can cause skin allergies and infections, and antifungal treatments like ketoconazole are effective against it.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.