24 citations
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May 2019 in “PLOS genetics” This study reports that compound heterozygous loss-of-function mutations in the HEPHL1 gene in a child were associated with abnormal hair and cognitive issues, linking altered ferroxidase activity to hair disorders.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that low-dose blue light (453nm) may positively affect hair growth by interacting with the receptors CRY1 and OPN3 in hair follicle cells.
5 citations
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February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that in a mouse model of Leigh syndrome, rapamycin alters brain proteome and may extend survival by targeting protein kinase C.
34 citations
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August 2002 in “British Journal of Dermatology” This study observed that two patients treated with interferon α-2b and ribavirin for chronic hepatitis C experienced complete and reversible straightening of their natural curly hair, which recurred with treatment resumption.
42 citations
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September 2007 in “The Journal of Clinical Endocrinology and Metabolism” This study found that women with PCOS who have an exaggerated 17-hydroxyprogesterone response to buserelin exhibit more severe hyperandrogenemia, increased insulin secretion, and reduced insulin sensitivity.
26 citations
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December 2020 in “Nature metabolism” Martin-Perez et al. show that rapamycin's beneficial effects in a mouse model of Leigh syndrome are linked to the downregulation of protein kinase C.
5 citations
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June 2020 in “Medicine” This report discusses a 22-year-old patient with MELAS syndrome carrying the m.10158T>C mutation, and highlights the need for extensive genetic testing when initial hot-spot mutation tests are negative.
November 2024 in “International Journal of Agricultural Invention” This review highlights the therapeutic properties and nutritional value of amla (Phyllanthus emblica), noting its high vitamin C content and diverse pharmacological activities, including antidiabetic and antioxidant effects, as evidenced in traditional medicine practices.
11 citations
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February 2021 in “Frontiers in Bioengineering and Biotechnology” This study suggests that short-term treatments with specific small molecules may enhance the differentiation potential and stem cell properties of human amniotic fluid stem cells.
This study observed that methylene blue, a mitochondrial-targeted antioxidant, promotes hair follicle stem cell proliferation and viability through reduced oxidative stress and enhanced β-catenin signaling, and it may also protect against hair loss related to glucagon-like peptide-1 receptor agonists by reducing metabolic stress.
6 citations
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September 2023 in “International journal of molecular sciences” This review explores the connection between oxidative stress and polycystic ovary syndrome, discussing potential mechanisms and the possible role of antioxidants; it reports no new clinical results.
February 2024 in “Skin health and disease” This source reviews popular cosmeceutical ingredients for skin care, noting that while they are popular among consumers for anti-aging benefits, many lack robust clinical evidence for their efficacy and safety, as they are not regulated by the FDA.
November 2025 in “Journal of Pharmacy and Pharmacology” This review highlights pigment epithelium-derived factor's roles in ageing and development, focusing on its antioxidant functions and support of stem cell survival, but reports no new experimental results.
40 citations
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December 2016 in “Journal of Ovarian Research” In this study on rats, rutin showed dose-dependent improvements in hormonal, antioxidant, and lipid profiles related to polycystic ovary syndrome, with effects comparable to metformin.
6 citations
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October 2017 This review summarizes the antioxidant and anticarcinogenic properties of Indian Gooseberry, its phytochemical composition, and its use in traditional Ayurvedic medicine, but reports no new clinical results.
37 citations
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August 2019 in “Frontiers in Microbiology” This study found that the S. epidermidis A/C lineage is more pathogenic due to its metabolic and genomic versatility, which allows it to adapt quickly from a commensal to a pathogenic lifestyle.
2 citations
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January 2025 in “International Journal of Molecular Sciences” This study found that chitosan nanoparticles containing Cordyceps militaris effectively reduced lung damage in mice exposed to fine particulate matter (PM2.5) by decreasing oxidative stress and preserving lung barrier integrity, suggesting potential as a therapeutic candidate for PM2.5-induced lung diseases.
1 citations
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September 2025 in “Journal of Cosmetic Dermatology” This study introduces the "skinspan" framework to promote skin longevity through sun protection, topical retinoids, and antioxidants as first-line care. It suggests lasers and emerging therapies as additional options but emphasizes the need for more randomized controlled trials to solidify the evidence base.
2 citations
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June 2023 in “Food science & nutrition” This review summarizes evidence that apple and apple products may offer protective effects against various health issues, including cardiovascular diseases, cancer, mild cognitive impairment, and skin conditions, due to their phytochemical content and mechanisms like anti-inflammatory and antioxidant actions.
March 2008 in “British Journal of Pharmacology” This guide provides an overview of the complex roles and mechanisms of various receptors and channels in pharmacology but does not report new experimental results.
30 citations
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October 2020 in “Frontiers in Plant Science” In this study, the combination of arsenic toxicity and hypoxia in Arabidopsis thaliana altered root development through stress-specific root growth phenotypes and changes in phosphate starvation response, energy metabolism, and redox signaling.
November 2025 in “Food Science & Nutrition” In this study, researchers found that topical apigenin promoted hair growth in a testosterone-induced alopecia mouse model, with effects comparable to minoxidil, suggesting a potential treatment approach for androgenetic alopecia through the Wnt signaling pathway.
147 citations
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January 2014 in “American Journal of Clinical Dermatology” This study found that low-level laser treatment with the HairMax Lasercomb significantly increased terminal hair density in both men and women with pattern hair loss, with no serious adverse events reported.
60 citations
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December 2015 in “Lasers in Medical Science” This review concluded that FDA-cleared low-level laser therapy devices are safe and effective for patients with male and female pattern hair loss who do not respond to or tolerate standard treatments.
41 citations
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December 2017 in “Lasers in Medical Science” This study found that low-level laser therapy may significantly improve androgenic alopecia in both men and women, either alone or alongside treatments like minoxidil and finasteride.
36 citations
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March 2011 in “Nature Communications” This study found that TSC2-null fibroblast cells from TSC skin hamartomas can induce hair follicle formation and hamartomatous changes in keratinocytes, with active mTOR signaling observable in a mouse xenograft model.
28 citations
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December 2017 in “Lasers in Medical Science” This review assessed evidence on laser therapies for alopecia areata, reporting that the 308-nm excimer laser showed hair regrowth in several studies, while more research is needed for other laser types.
10 citations
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June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified FP-1 as a highly specific extracellular matrix protein in follicular papilla cells, which may play a role in hair growth regulation during specific hair cycle phases.
September 2024 in “Research Square (Research Square)” This study found that bi-weekly 1550nm low-level laser therapy significantly improved hair loss conditions and scalp health in participants, suggesting its potential as an effective non-invasive treatment option.
157 citations
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May 2021 in “Endocrine Reviews” This review discusses recent advancements in understanding and managing congenital adrenal hyperplasia, including improvements in screening, diagnostics, and potential genetic and cell-based treatments, but reports no new clinical findings.