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Over half of the adult women with acne in the study had higher than normal levels of male hormones, especially DHEA.

Doctors should know how to diagnose and treat PCOS, which often involves checking for high male hormone levels and using medications to manage symptoms.

FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.

Extramammary Paget disease can spread deeply into tissues, reaching up to 3.6 mm.

Brazilian women with PCOS and both menstrual irregularity and high male hormone levels have a higher chance of having metabolic syndrome.

Antiandrogens can help treat skin conditions like acne and excessive hair in women when used carefully.

APS-1 in Italy shows diverse AIRE mutations and various autoimmune issues.

Curcumin may improve blood sugar levels and cholesterol in people with PCOS, but more research is needed.

Skin organoids are a promising new model for studying human skin development and testing treatments.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.

The study suggests that being overweight or obese, not PCOS itself, is strongly linked to insulin resistance.

Menopause affects hair and skin; more research needed for treatment.

The document describes a woman with familial Parkinson's disease due to a genetic mutation, showing severe symptoms and poor response to treatment, and suggests finasteride may help reduce symptoms in Tourette syndrome.

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.

Continuous light exposure in rats leads to PCOS-like symptoms and suggests sleep habits might affect the disorder's development.

A team approach is crucial for managing PCOS, with dermatologists playing a key role.

Diagnosing PCOS in teenagers is hard because its symptoms often look like normal puberty, and there's a need for better diagnosis methods and agreement on criteria.

Thyroid hormones are important for skin health and might help treat skin diseases, but more research is needed to understand their effects fully.

Nonclassic congenital adrenal hyperplasia is a genetic disorder causing hormone imbalances, affecting fertility and requiring personalized treatment.

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.

Hormonal therapy is a good option for women with severe acne, especially when there's a chance of hormone imbalance.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

High-content screening is useful for finding new treatments for rare diseases and has led to FDA-approved drugs.

The study found that mouse sweat glands develop before birth, mature after birth, and have specific keratin patterns.