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DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

MicroRNAs could be key biomarkers and therapeutic targets for PCOS.

Male-pattern hair loss is largely influenced by genetics, with key genes identified.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Two gene variations, rs6493497 and rs7176005, may be linked to female hair loss in Chinese people.

Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.

Aromatase gene variation may increase female hair loss risk.

Genes and hormones cause hair loss, with four genes contributing equally.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Six new genetic regions linked to early hair loss also connect to Parkinson's disease and prostate cancer, possibly leading to new treatments.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

DHT, a testosterone byproduct, causes male pattern baldness.

Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.

Genetic mutations can affect female sexual development, requiring personalized medical care.

The paper suggests that hair loss might be caused by skull growth, not just DHT's effect on hair follicles, and calls for more research.

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The document concludes that PCOS has a strong genetic component, but more research is needed to fully understand the specific genes involved.

Two women with very high androgen levels had only slight skin issues, one due to a non-classical adrenal disorder and the other due to an adrenal tumor.

Early treatment of PCOS in teens is crucial to prevent long-term health issues like diabetes and heart disease.

PCOS is a genetic disorder affecting women's reproductive health, with treatments focused on symptoms like insulin resistance and fertility.