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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

PGD2 stops hair growth and is higher in bald men with AGA.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Estrogen therapy can reduce skin aging but has cancer risks.

About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Hair loss in men treated best with early medication or transplant, new treatments researched.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Female Pattern Hair Loss affects women's self-esteem and needs more research for better treatment.

TCDD speeds up skin barrier formation by increasing certain gene expressions.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Low-dose oral minoxidil and spironolactone combo effectively reduces hair loss and improves hair density in women.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Red ginseng may improve immunity, fatigue, memory, blood circulation, and menopausal symptoms, and is generally safe to consume.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

CYP2B12 enzyme in skin cells converts arachidonic acid into specific bioactive lipids.

Female pattern hair loss is common, linked to polycystic ovarian syndrome, and treated with topical Minoxidil.

Spironolactone helps regrow hair in women with hair loss.

Certain drugs that block specific enzymes can help treat prostate diseases.

Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

Use "female pattern hair loss" term, assess androgen excess, treat with minoxidil and other medications if needed.

The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Women with early hair loss have higher blood pressure and aldosterone; screening and treatment may help.