Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that 11α-hydroxyprogesterone is a potent inhibitor of 11βHSD2 in vitro and may serve as a precursor to unique C11α-hydroxy steroids in prostate cancer tissue.

This study observed a strong overall reduction in the use of CPA/EE in the Netherlands, despite similar proportions of users with acne or other hyperandrogenic conditions before and after the referral procedure.

This case report indicates that HAIR-AN syndrome can lead to severe hyperandrogenism with virilisation signs in women after excluding tumoral causes and identifying signs of insulin resistance.

This case study describes a 17-year-old female with severe hirsutism diagnosed with PCOS, NC-CAH, and HAIR-AN syndrome who was successfully treated based on her specific underlying conditions.

This review discusses hormonal manipulation for conditions like prostatic disorders and skin issues and highlights promising treatments like casodex and finasteride, but it reports no new clinical results.

This article discusses the mechanisms of hirsutism and acne in women, highlighting cyproterone acetate with ethinyloestradiol as an effective anti-androgen therapy in the UK, but it reports no new clinical findings.

This article discusses the mechanisms and therapeutic use of antiandrogens, specifically cyproterone acetate and chlormadinone acetate, in gynecological treatments without reporting new clinical results.

This study found that a novel R343H mutation in the vitamin D receptor gene impairs its transcription activity, contributing to hereditary vitamin D-resistant rickets and alopecia in the affected family.

This review explores the hormonal factors related to hidradenitis suppurativa, emphasizing insulin resistance and pro-inflammatory adipokines, but reports no new clinical findings and suggests further research is needed.

This review discusses idiopathic hirsutism and suggests that combination treatment, including androgen suppression and cosmetic methods, is most effective, but notes that its pathogenesis remains unclear.

The researchers reported that shiitake mushroom, buckwheat, soybean, cypress, and seaweed fulvescens showed potential as safe and effective natural ingredients for scalp care and scaling due to their antioxidative and antimicrobial properties.

This review summarizes the structural and chemical characteristics of current and novel antiandrogenic drugs but reports no new clinical findings.

This case study observed that long-term itraconazole and budesonide use in a cystic fibrosis patient led to iatrogenic Cushing's syndrome due to inhibited metabolic clearance of budesonide, suggesting a need for regular adrenal insufficiency monitoring in such treatments.

Antiandrogens help manage PCOS symptoms but need careful monitoring.

This article discusses primary cutaneous virilism, focusing on alopecia in women with androgen-dependent skin conditions, and reports no new findings.

This review reports that nirmatrelvir-ritonavir has significant drug-drug interactions with many common dermatological medications, whereas molnupiravir may be an alternative therapy due to the absence of such interactions observed so far.

In this study, sustained-release sodium valproate showed high efficacy in achieving seizure remission for adults with focal and generalized epilepsy over one year, but side effects like weight gain and tremor were more frequent among heterozygous carriers of certain gene variants.

This article reviews hirsutism from an endocrine perspective and reports no new clinical findings.

This study found that cortexolone 17α-propionate showed strong topical antiandrogenic activity, outperforming progesterone and several known antiandrogens, but lacked systemic antiandrogenic effects in animal models.

This article reviews the clinical characterization and potential treatments for androgenetic alopecia, highlighting minoxidil's efficacy in hair regrowth and noting the need for further genetic research; it reports no new clinical results.

This study found that treatment with cyproterone acetate and ethinylestradiol in hirsute women reduced testosterone and androstenedione levels, decreased hair growth, and increased cortisol levels without changing catecholamine excretion.

Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.

In this study, PFOS exposure altered steroid hormone levels and enzyme activities related to steroidogenesis in juvenile Silurana tropicalis, with effects differing between male and female frogs.

This review analyzed past research on hormonal treatments for hidradenitis suppurativa, finding that anti-androgens like finasteride and spironolactone, along with metformin, showed promise but large-scale trials are needed to understand their full potential.

In this study, only Vdr-knockout rats showed both abnormal skin formation and alopecia, which may provide insights into vitamin D receptor function and its role in the hair growth cycle.

This review discusses gender-affirming hormone therapies in South Korea, detailing the available treatment regimens and associated side effects, but reports no new clinical findings.

This review discusses the use of CDK4/6 inhibitors with endocrine therapy in treating women with HR+ HER2- advanced breast cancer, but it reports no new clinical findings.

This article reviews the diagnosis and management of polycystic ovary syndrome, emphasizing lifestyle changes and treatment strategies, and reports no new clinical results.

This article discusses the multifactorial nature of acne vulgaris, detailing its link to androgen-induced sebum production, altered keratinisation, inflammation, and bacterial colonisation, but reports no new research findings.

This study found that testosterone significantly stimulated the proliferation of outer root sheath cells when co-cultured with beard or axillary dermal papilla cells, but not with cells from occipital scalp hair follicles.