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    Glossary Cyclosporine

    immunosuppressive drug used to prevent organ rejection and treat autoimmune diseases

    Cyclosporine, also known as cyclosporin A or CsA, is an immunosuppressive drug primarily used to prevent organ transplant rejection and to treat certain autoimmune conditions. It works by inhibiting the activity of T-cells, a type of white blood cell involved in the immune response. In dermatology, cyclosporine has been explored for its potential to treat severe cases of alopecia areata, a condition characterized by sudden hair loss.

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    1. The use of cyclosporine in dermatology: Part I Journal of the American Academy of Dermatology · 2010 · 131 citations
    2. A Murine Model for Inducing and Manipulating Hair Follicle Regression (Catagen): Effects of Dexamethasone and Cyclosporin A Journal of Investigative Dermatology · 1994 · 124 citations
    3. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles PLOS Biology · 2018 · 68 citations
    4. Cyclosporin: applications in small animal dermatology Veterinary Dermatology · 2003 · 59 citations
    5. Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes American Journal of Physiology-cell Physiology · 2003 · 57 citations
    6. Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants Journal of Dermatological Science · 1994 · 54 citations
    7. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001 · 45 citations
    8. Cyclosporine for moderate-to-severe alopecia areata: A double-blind, randomized, placebo-controlled clinical trial of efficacy and safety Journal of the American Academy of Dermatology · 2019 · 44 citations
    9. Cyclosporin in dermatology: A practical compendium Dermatologic Therapy · 2020 · 36 citations
    10. Efficacy of combined cyclosporine A and ketoconazole treatment of anal furunculosis 2004 · 36 citations
    11. Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone. PubMed · 1994 · 36 citations
    12. Three cases of immune‐mediated adnexal skin disease treated with cyclosporin Veterinary Dermatology · 2006 · 36 citations
    13. Differences in activity of minoxidil and cyclosporin A on hair growth in nude and normal mice. Comparisons of in vivo and in vitro studies. PubMed · 1990 · 35 citations
    14. Effects of cyclosporine A on clinical and histologic abnormalities in dogs with sebaceous adenitis Journal of the American Veterinary Medical Association · 2005 · 34 citations
    15. Partial Response of Severe Alopecia areata to Cyclosporine A Dermatology · 1999 · 30 citations
    16. Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles Journal of Investigative Dermatology · 2015 · 29 citations
    17. ALOPECIA UNIVERSALIS TREATED WITH ORAL CYCLOSPORINE A AND PREDNISOLONE: IMMUNOLOGIC STUDIES International Journal of Dermatology · 1992 · 26 citations
    18. Alopecia areata presenting in 2 kidney-pancreas transplant recipients taking cyclosporine Journal of The American Academy of Dermatology · 2005 · 23 citations
    19. Combination Therapy with Cyclosporine and Psoralen Plus Ultraviolet A in the Patients with Severe Alopecia Areata: A Retrospective Study with a Self-Controlled Design 2013 · 21 citations
    20. Cyclosporine Archives of Dermatology · 1990 · 20 citations
    21. Comparison of High-Dose Corticosteroid Pulse Therapy and Combination Therapy Using Oral Cyclosporine with Low-Dose Corticosteroid in Severe Alopecia Areata 2015 · 14 citations
    22. A Comparative Study of Oral Cyclosporine and Betamethasone Minipulse Therapy in the Treatment of Alopecia Areata 2016 · 14 citations
    23. Identification of a Cyclosporine-Specific P450 Hydroxylase Gene through Targeted Cytochrome P450 Complement (CYPome) Disruption in Sebekia benihana Applied and Environmental Microbiology · 2013 · 13 citations
    24. Utility of azathioprine, methotrexate and cyclosporine as steroid‐sparing agents in chronic alopecia areata: a retrospective study of continuation rates in 138 patients 2020 · 12 citations
    25. Cyclosporine A stimulated hair growth from mouse vibrissae follicles in an organ culture model Journal of Nanjing Medical University · 2012 · 11 citations
    26. Greater conversion of testosterone to 5α-dihydrotestosterone, reflecting increased peripheral 5α-reductase activity in nude mice treated with high doses of cyclosporine A Journal of Steroid Biochemistry · 1990 · 10 citations
    27. Cyclosporine A increases hair follicle growth by suppressing apoptosis-inducing factor nuclear translocation: a new mechanism Fundamental & clinical pharmacology · 2015 · 9 citations
    28. Structural characterization of cyclosporin A, C and microbial bio-transformed cyclosporin A analog AM6 using HPLC–ESI–ion trap-mass spectrometry Talanta · 2014 · 7 citations
    29. Cyclosporine-A-Induced Intracranial Thrombotic Complications: Systematic Review and Cases Report Frontiers in Neurology · 2021 · 6 citations
    30. Induction of synapse associated protein 102 expression in cyclosporin A-stimulated hair growth Experimental Dermatology · 2008 · 5 citations