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    Glossary Cyclosporine

    immunosuppressive drug used to prevent organ rejection and treat autoimmune diseases

    Cyclosporine, also known as cyclosporin A or CsA, is an immunosuppressive drug primarily used to prevent organ transplant rejection and to treat certain autoimmune conditions. It works by inhibiting the activity of T-cells, a type of white blood cell involved in the immune response. In dermatology, cyclosporine has been explored for its potential to treat severe cases of alopecia areata, a condition characterized by sudden hair loss.

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    1. The use of cyclosporine in dermatology: Part I Journal of the American Academy of Dermatology · 2010 · 131 citations
    2. A Murine Model for Inducing and Manipulating Hair Follicle Regression (Catagen): Effects of Dexamethasone and Cyclosporin A Journal of Investigative Dermatology · 1994 · 124 citations
    3. Toxicity of the immune suppressant cyclosporin A in the rat The Journal of Pathology · 1982 · 116 citations
    4. Cyclosporin A: a new drug in the field of canine dermatology Veterinary Dermatology · 2004 · 84 citations
    5. Topical Cyclosporine in Alopecia Areata Archives of Dermatology · 1987 · 69 citations
    6. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles PLOS Biology · 2018 · 68 citations
    7. Management of patients and side effects during cyclosporine therapy for cutaneous disorders Journal of the American Academy of Dermatology · 1990 · 64 citations
    8. Cyclosporin: applications in small animal dermatology Veterinary Dermatology · 2003 · 59 citations
    9. Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes American Journal of Physiology-cell Physiology · 2003 · 57 citations
    10. Cyclosporine-induced folliculodystrophy Journal of the American Academy of Dermatology · 2004 · 56 citations
    11. Cyclosporin A stimulates hair growth in nude mice. PubMed · 1987 · 55 citations
    12. Treatment of alopecia areata in the DEBR model using Cyclosporin A lipid vesicles. PubMed · 2004 · 54 citations
    13. Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants Journal of Dermatological Science · 1994 · 54 citations
    14. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001 · 45 citations
    15. Cyclosporine for moderate-to-severe alopecia areata: A double-blind, randomized, placebo-controlled clinical trial of efficacy and safety Journal of the American Academy of Dermatology · 2019 · 44 citations
    16. Three cases of immune‐mediated adnexal skin disease treated with cyclosporin Veterinary Dermatology · 2006 · 36 citations
    17. Cyclosporin in dermatology: A practical compendium Dermatologic Therapy · 2020 · 36 citations
    18. Efficacy of combined cyclosporine A and ketoconazole treatment of anal furunculosis 2004 · 36 citations
    19. Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone. PubMed · 1994 · 36 citations
    20. Differences in activity of minoxidil and cyclosporin A on hair growth in nude and normal mice. Comparisons of in vivo and in vitro studies. PubMed · 1990 · 35 citations
    21. Effects of cyclosporine A on clinical and histologic abnormalities in dogs with sebaceous adenitis Journal of the American Veterinary Medical Association · 2005 · 34 citations
    22. Topical cyclosporine in male pattern alopecia Journal of the American Academy of Dermatology · 1990 · 33 citations
    23. The effect of oral cyclosporine in the treatment of severe alopecia areata Cutaneous and ocular toxicology · 2013 · 33 citations
    24. Partial Response of Severe Alopecia areata to Cyclosporine A Dermatology · 1999 · 30 citations
    25. Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles Journal of Investigative Dermatology · 2015 · 29 citations
    26. ALOPECIA UNIVERSALIS TREATED WITH ORAL CYCLOSPORINE A AND PREDNISOLONE: IMMUNOLOGIC STUDIES International Journal of Dermatology · 1992 · 26 citations
    27. Hair Growth on Nude Mice Due to Cyclosporin A The Journal of Dermatology · 1991 · 25 citations
    28. Topical application of cyclosporin A induces rapid-remodeling of damaged anagen hair follicles produced in cyclophosphamide administered mice Journal of Dermatological Science · 2001 · 24 citations
    29. The effect of topical cyclosporin on the immediate shedding of human scalp hair grafted onto nude mice British Journal of Dermatology · 1988 · 23 citations
    30. Alopecia areata presenting in 2 kidney-pancreas transplant recipients taking cyclosporine Journal of The American Academy of Dermatology · 2005 · 23 citations