August 2022 in “Biomedicines” Turning off the Lhx2 gene in mouse embryos leads to slower wound healing and scars.
November 2015 in “Hair transplant forum international” Early attempts at using cloned cells for hair transplants failed, but 3D cell growth showed some promise.
February 2023 in “International Journal of Molecular Sciences” Exosomes from skin cells can boost hair growth by stimulating a gene called LEF1.
488 citations,
July 2021 in “Cell” Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
161 citations,
October 2012 in “Seminars in cell & developmental biology” Hair growth and development are controlled by specific signaling pathways.
136 citations,
October 2019 in “Journal of Clinical Investigation” Dermal adipose tissue in mice can change and revert to help with skin health.
134 citations,
August 2020 in “Experimental dermatology” Hair follicles are normally protected from the immune system, but when this protection fails, it can cause hair loss in alopecia areata.
130 citations,
March 2014 in “Proceedings of the National Academy of Sciences of the United States of America” Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.
115 citations,
December 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.
112 citations,
January 2004 in “The International journal of developmental biology” Feather patterns form through genetic and epigenetic controls, with cells self-organizing into periodic patterns.
101 citations,
April 2019 in “Cell Stem Cell” Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.
96 citations,
September 2021 in “International Journal of Molecular Sciences” Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.
86 citations,
August 2021 in “Polymers” Microneedles are effective for drug delivery, vaccinations, fluid extraction, and treating hair loss, with advancements in manufacturing like 3D printing.
67 citations,
November 2019 in “Molecules” Tea, especially green tea, shows promise in cosmetics for skin and hair benefits but more research is needed for effective use.
63 citations,
February 2017 in “ACS biomaterials science & engineering” Polydopamine is a safe, effective, and permanent hair dye that turns gray hair black in one hour.
58 citations,
August 2015 in “The Indonesian Biomedical Journal” Different types of stem cells help maintain and heal skin.
55 citations,
March 2010 in “Aging” Circadian clock genes are important for hair growth and may affect aging-related hair loss and graying.
54 citations,
January 2023 in “Signal Transduction and Targeted Therapy” New therapies are being developed that target integrin pathways to treat various diseases.
37 citations,
May 2018 in “Frontiers in physiology” Certain RNA molecules are important for the development of wool follicles in sheep.
37 citations,
November 2017 in “Medical Sciences” Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.
29 citations,
July 2021 in “Journal of Investigative Dermatology” Fat under the skin releases HGF which helps hair grow and gain color.
27 citations,
May 2019 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine” The best method for urethral reconstruction is using hypoxia-preconditioned stem cells with autologous cells on a vascularized synthetic scaffold.
25 citations,
July 2022 in “Developmental cell” Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
22 citations,
July 2020 in “iScience” Sox21 is crucial for tooth development and enamel formation by preventing cells from changing into a different type.
22 citations,
June 2012 in “The American journal of pathology” Loss of Msx2 function causes eye development issues similar to Peters anomaly.
19 citations,
January 1997 in “Endocrinology” Testosterone can slow hair growth in adult monkeys, but a blocker called RU 58841 can counteract this and potentially help hair regrow.
18 citations,
August 2017 in “PLOS ONE” Skin and its underlying fat layer act together to resist mechanical stress, and reinforcing this composite structure may help more with anti-aging than just strengthening the skin alone.
17 citations,
May 2015 in “Cell transplantation” Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.
16 citations,
November 2019 in “Journal of biological chemistry/The Journal of biological chemistry” Mice without certain skin enzymes have faster hair growth and bigger eye glands.
16 citations,
May 2019 in “The journal of pain/Journal of pain” 14,15-EET may help reduce poststroke pain by affecting certain brain proteins.