In this study with mice, simultaneous inactivation of Smad4 and PTEN genes led to rapid development of invasive forestomach squamous cell carcinomas, mirroring human esophageal SCCs.
In this study, the deletion of Smad4 and PTEN genes in mice was associated with rapid and invasive squamous cell carcinoma formation in the forestomach, modeling human esophageal cancer progression.
March 2023 in “Asian Journal of Beauty and Cosmetology” This study found that the herbal extract HX109 promoted hair growth in mice by increasing cell viability and enhancing hair regrowth, with the effects increasing as doses rose.
April 2021 in “Current Topics in Nutraceutical Research” This study found that citron seed oil promotes hair regrowth in a C57BL/6 mouse model by enhancing the transition to the growth phase, increasing hair follicle features and skin thickness, and inducing specific protein expressions that support hair regeneration.
September 2016 in “Journal of dermatological science” This study suggests that FGF18 may enhance radioresistance in telogen hair follicles by inducing cell cycle arrest, potentially serving as a radioprotector against radiation-induced hair follicle damage.
April 2016 in “Journal of Investigative Dermatology” This study suggests that lithocholic acid may enhance hair regeneration in alopecia by activating vitamin D receptors in human dermal papilla cells.
This study suggests that Grateloupia elliptica extract may promote hair growth by activating wnt/β-catenin signaling and fostering dermal papilla cell proliferation.
January 2016 in “Korean Journal of Pharmacognosy” This study found that Grateloupia elliptica extract may promote hair growth by activating wnt/b-catenin signaling and enhancing dermal papilla cell proliferation in rat and mouse models.
This study found that Clitocybin A from Clitocybe aurantiaca may promote hair growth in immortalized rat dermal papilla cells by enhancing cell proliferation and activating Wnt/β-catenin signaling and ERK pathways.
August 2013 in “eCommons (Cornell University)” This study found that transcriptional regulation by Runx1 and cyclin-dependent kinase inhibitors plays a crucial role in maintaining quiescence and promoting fate decision flexibility in hair follicle stem cells.
In this study, the n-hexane fraction of wheat bran significantly promoted hair growth in rat vibrissa follicles and triggered the telogen-anagen transition in C57BL/6 mice, likely through cell cycle and Wnt/β-catenin signaling pathways.
April 2010 in “Cancer Research” In this study, Stat3 activation in transgenic mice led to a decrease in stem cells in the hair follicle bulge, suggesting its crucial role in epidermal growth and stem cell maintenance.
January 2023 in “Iranian Journal of Pharmaceutical Research” This study concluded that S. hexaphylla extract may improve androgenetic alopecia by reducing 5α-reductase and androgen receptor levels, inhibiting apoptosis, and promoting keratinocyte proliferation in experimental models.
40 citations
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May 2010 in “Australasian Journal of Dermatology” This study suggests that chronic telogen effluvium may be due to a reduction in the variance of anagen duration, resulting in recurrent hair shedding with minimal long-term hair volume loss.
6 citations
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October 2022 in “Frontiers in Physiology” This review discusses the roles of store-operated Ca 2+ entry proteins in skin cell function and their links to various skin diseases, but it reports no new results.
4 citations
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August 2022 in “Cells” This study found that the lncRNA lncRNA2919 is involved in hair follicle regeneration by downregulating growth-related genes, inhibiting cell proliferation, and promoting apoptosis in rabbit dermal papilla cells.
3 citations
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June 2020 in “Open access rheumatology” This case report reviews the management of Rowell syndrome in a patient initially diagnosed with Rhupus syndrome and highlights their development of erythema multiforme after certain medications.
September 2021 in “CRC Press eBooks” This article describes telogen effluvium as diffuse cyclic hair loss in women caused by systemic stresses, diseases, or physiological situations, but reports no new clinical results.
November 2025 in “Journal of Investigative Dermatology” Keloid fibroblasts cause itch and pain by releasing more histamine.
521 citations
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January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
January 2026 in “Journal of Innovative and Creativity (Joecy)” This study investigated hair growth tonics made with celery leaf extract and found that 4% and 9% concentrations maintained better cyclic stability than 14%, supporting their potential use in herbal cosmetic development due to favorable physicochemical stability.
4 citations
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May 2019 in “Journal of Clinical Oncology” This study found that cyclin-dependent kinase 4/6 inhibitors used for metastatic breast cancer caused alopecia resembling androgenetic alopecia, negatively impacting patients' quality of life, but topical minoxidil showed potential for improvement.
74 citations
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December 1995 in “The Journal of Clinical Endocrinology & Metabolism” This study found that treatment with leuprolide plus cyclic estrogen/progestin may lead to a faster and greater improvement in hirsutism compared to a standard oral contraceptive regimen.
8 citations
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January 2003 in “Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy” This case report documents a cancer survivor who experienced cyclic alopecia areata following chemotherapy, suggesting potential autoimmune changes related to the treatment.
February 2004 in “Oncology Times” This presentation by Dr. Shutsung Liao suggests that a treatment approach involving cyclic use of androgens and anti-androgens, along with green tea extract, may help extend survival in advanced prostate cancer patients resistant to standard therapy.
7 citations
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September 2003 in “Journal of Investigative Dermatology” In this study, researchers found that thrombin may influence cyclic hair growth through its receptor PAR-1, although it does not seem to stimulate dermal papilla cell proliferation physiologically.
November 2023 in “Elsevier eBooks” This study found that vitamin D receptor mutations lead to hair follicle alopecia due to impaired cyclic regeneration, which is distinct from vitamin D receptor effects on epidermal keratinocytes that largely depend on 1,25-dihydroxyvitamin D.
4 citations
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March 2014 in “The FASEB Journal” This study observed that deleting ARNT in keratinocytes of mice reduced zigzag hair production and altered hair follicle differentiation, likely by affecting the expression of specific cyclin-dependent kinase inhibitors.
July 2023 in “New phytologist” This research identified a genetic mutation in Brachypodium distachyon that initially allows root hair initiation but fails to elongate them, while also affecting root growth and nitrate sensitivity; the mutation is linked to a previously uncharacterized cyclin-dependent kinase-like gene.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that p21 is much more highly expressed in normal melanocytes compared to melanoma cells, suggesting a potential target for preventing melanoma progression through cell cycle repair processes.