76 citations
,
November 2009 in “Medical Clinics of North America” This article reviews the hormonal and medication-related factors associated with acne development but does not present new research findings.
72 citations
,
July 2012 in “Journal of Investigative Dermatology” This study found that mice with a specific loss of DNA methyltransferase 1 showed uneven epidermal thickness, reduced hair regeneration, and progressive alopecia, emphasizing DNA methylation's role in stem cell homeostasis.
53 citations
,
November 2006 in “Journal of Endocrinology” This study found that prolactin plays a direct role in regulating the timing of hair growth cycles in mice by affecting the skin, rather than through other endocrine factors.
53 citations
,
May 1986 in “Clinics in endocrinology and metabolism” This review discusses the influence of androgens on hair and sebaceous growth, emphasizing that response may depend more on peripheral sensitivity than on hormone levels; it reports no new empirical results.
40 citations
,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the S100A3 gene is exclusively expressed in hair follicle cells differentiating into hair shaft components in mice, suggesting its important role in hair formation.
39 citations
,
January 2016 in “PubMed” This review discusses the role of epidermal differentiation complex genes and epigenetic mechanisms in skin development and certain diseases, emphasizing their potential for improving drug development and delivery systems but provides no new experimental results.
30 citations
,
March 2015 in “PLoS ONE” This study found that thyroxine modulates peripheral molecular clock gene expression in human hair follicles, which may have implications for treating clock-related diseases in patients with thyroid dysfunction.
28 citations
,
April 2008 in “Journal of Inclusion Phenomena and Macrocyclic Chemistry” This study identified a weak interaction between minoxidil and ß-cyclodextrin in solution, forming an inclusion complex with a 1:1 molar ratio.
25 citations
,
January 1983 in “Analyst” Method measures minoxidil in tablets accurately and easily.
22 citations
,
July 2012 in “Journal of integrative agriculture/Journal of Integrative Agriculture” This study found that Hoxc13 gene expression, influenced by melatonin, was associated with hair follicle activity in Cashmere goats, with in vitro evidence suggesting effects on genes relevant to follicle development.
22 citations
,
February 2008 in “Journal of Neurochemistry” This study found that minoxidil prevents long-term serotonergic toxicity induced by MDMA in rats, primarily by opening mitochondrial KATP channels and involving Akt and MAP kinases in its neuroprotective mechanism.
22 citations
,
November 2007 in “Journal of Investigative Dermatology Symposium Proceedings” This presentation reviews recent discoveries about signaling mechanisms in hair follicles and their potential influence on hair cycle control and melanogenesis, without presenting new experimental results.
20 citations
,
October 2008 in “Archives of dermatological research” This study found that angiogenin is expressed in human dermal papilla cells, where it might stimulate hair growth by promoting cell proliferation and local skin angiogenesis.
19 citations
,
December 2018 in “Experimental and Molecular Medicine” This study reports that the novel small molecule IM176OUT05, by modifying stem cell metabolism, promoted hair regrowth and increased hair follicle numbers in mice.
14 citations
,
January 2016 in “Elsevier eBooks” This article discusses the benefits of liposomes in cosmetic formulations, including enhanced hydration and protection for dry skin, but reports no new experimental findings.
11 citations
,
September 2012 in “Journal of Nanjing Medical University” In this study, cyclosporine A stimulated hair growth in mouse vibrissae organ culture by promoting matrix cell proliferation and altering growth factor expression.
11 citations
,
January 1998 in “Dermatology” This review explores various substances with potential antiandrogenic effects for treating acne, highlighting evidence for isotretinoin, and discusses the future consideration of 5 alpha-reductase inhibitors as antiandrogens.
8 citations
,
January 2020 in “Skin Pharmacology and Physiology” This article discusses the potential for topical caffeine as a natural alternative for treating androgenetic alopecia due to its ability to penetrate skin, but it reports no new clinical findings.
8 citations
,
January 2017 in “Stem Cells International” This study found that overexpression of sFRP4 in skin cells reduces Wnt signaling activation, leading to decreased melanocyte differentiation in regenerating hair follicles.
8 citations
,
May 2013 in “Journal of Investigative Dermatology” This review explores the molecular processes behind hair follicle stem cell activation and suggests new potential targets for designing therapies for various types of alopecia, but it reports no clinical results.
5 citations
,
March 2019 in “Scientific Reports” This study reports that the side population technique can isolate melanocyte stem cells from human hair follicles, potentially allowing them to be used for skin pigmentation repopulation.
4 citations
,
May 2018 in “Electronic Journal of Biotechnology” This study found that all-trans retinoic acid (ATRA) negatively affects hair growth by reducing goat dermal papilla cell viability and growth factor expression.
3 citations
,
April 2019 in “Journal of Dermatological Treatment” This review discusses the use of phosphodiesterase inhibitors for alopecia, finding promising preliminary results with topical caffeine for androgenetic alopecia and telogen effluvium, but limited success in alopecia areata.
1 citations
,
January 2014 in “Elsevier eBooks” This review discusses melanocytes' role in pigmentation, their clinical significance in conditions like vitiligo and hair graying, and highlights current research on hair follicle regeneration without reporting new clinical results.
January 2024 in “Applied Mathematics and Nonlinear Sciences” This study developed a mathematical model to explore the interactions between hair cycle dynamics and immune system activity in alopecia areata, providing insights into disease progression and potential targets for treatment by simulating immune response effects on hair follicles.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a novel mechanism by which dsRNA-induced TLR3 activation and retinoic acid pathways contribute to new hair follicle formation after deep wounds in mice and suggested a similar potential in humans.
January 2018 in “Elsevier eBooks” This chapter reviews various in vitro and laboratory animal models for studying potential therapies for alopecia and reports no new results.
January 2018 in “Springer eBooks” Terbinafine is the most effective medicine for fungal nail infections, especially for diabetics and those with weak immune systems.
October 2017 in “The Indian Journal of Animal Sciences” This study found that prolactin gene polymorphism in Changthangi goats showed no significant association with Cashmere quality traits, indicating the need for further research with larger sample sizes.
March 2014 in “Institutional Repositories DataBase (IRDB)” Skin-derived stem cells could help treat skin aging and pigmentation issues.