26 citations
,
December 1981 in “British journal of dermatology/British journal of dermatology, Supplement” This study observed that most hirsute patients on combined cyproterone acetate and 'Diane' therapy experienced a reduction in hair growth, with hair becoming softer, thinner, and lighter in color over 12 months.
25 citations
,
December 2018 in “Human Molecular Genetics” This study found that the PSEN1-P242LfsX11 mutation in hidradenitis suppurativa influences cytokine and chemokine expression in macrophages, potentially affecting inflammatory responses.
25 citations
,
December 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This study suggests that targeting specific immune pathways, such as IL-12/23 and Th2 cytokines, may offer new treatment options for alopecia areata, a T-cell-mediated disease without current mechanism-specific therapies.
25 citations
,
August 2015 in “Molecules” This study found that mimosine dipeptide enantiomers inhibit melanogenesis and cyclooxygenase enzymes in B16F10 melanoma cells, suggesting potential for treating skin hyperpigmentation and inflammation.
25 citations
,
March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that while VDR is crucial for maintaining hair follicles in mice, their degeneration may be linked to impaired cell migration during hair growth phases rather than stem cell loss.
25 citations
,
December 1991 in “The Journal of Dermatology” This study found that cyclosporin A treatment in young nude mice induced dose-dependent hair growth, which stopped after treatment cessation, but did not result in hair growth in older mice.
24 citations
,
October 2019 in “Genes” In this study, the identification of a novel KAP gene in sheep, named KRTAP36-1, was associated with increased prickle factor in wool, suggesting its potential as a genetic marker for breeding purposes.
24 citations
,
February 2011 in “The American journal of pathology” This study found that AIRE, a usually nuclear protein, is expressed in the cytoplasm of human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin 17, potentially impacting ectodermal abnormalities in APECED syndrome.
24 citations
,
September 2001 in “Journal of Dermatological Science” This study found that cyclophosphamide-induced hair follicle damage in C3H mice could be remodelled into intact anagen hair follicles with topical cyclosporin A, especially in anagen IV stage follicles.
23 citations
,
December 2021 in “Frontiers in Immunology” This review discusses the significance of IL-1 family cytokines in skin inflammation and pathology, emphasizing their interactions with microbes and potential therapeutic applications, but reports no new clinical results.
23 citations
,
March 2019 in “Environmental Chemistry Letters” This review examines the role of cyclodextrins in improving the solubility, stability, and bioavailability of steroid drugs but does not report new experimental findings.
23 citations
,
February 2019 in “International Journal of Molecular Sciences” This study found that Activin B at 10 ng/mL may promote vibrissae follicle growth in mice by enhancing hair matrix cell proliferation and cell cycle progression via ERK signaling pathways.
23 citations
,
June 2017 in “Drug Design Development and Therapy” This study found that the dimethyl-β-cyclodextrin inclusion system significantly improved the solubility and bioavailability of finasteride compared to the drug alone, enhancing its absorption rate.
23 citations
,
October 2005 in “Journal of The American Academy of Dermatology” This report describes the unexpected development of alopecia areata in kidney-pancreas transplant recipients undergoing cyclosporine-based immunosuppressive therapy, suggesting a complex relationship between the treatment and disease.
23 citations
,
April 1999 in “The Journal of Clinical Endocrinology and Metabolism” This study found that flutamide, finasteride, ketoconazole, and EE-CPA all significantly reduced hirsutism scores, hair diameter, and hair growth rate in women with hirsutism over 12 months.
23 citations
,
January 1997 in “Computers and Composition” This article discusses the dynamics of the "mole gaze" and cybersexism on the Web, analyzing interactions through personal and theoretical lenses, and suggests the need for both structural and psychological change to counteract these issues.
23 citations
,
October 1996 in “Dermatologic clinics” This review discusses genomic and postgenomic alterations in chronic degenerative diseases and potential modulation by dietary and pharmacological agents, reporting no new clinical results.
23 citations
,
December 1988 in “British Journal of Dermatology” This pilot study suggests that topical cyclosporin may delay hair shedding and potentially treat alopecia, based on observations in a human scalp skin graft model on mice.
22 citations
,
November 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that cathepsin L and transglutaminase 3 colocalize in the human hair bulb and nail matrix, suggesting their involvement in terminal differentiation within these epidermal appendages.
22 citations
,
July 1987 in “Transplantation” This study found that topical cyclosporine significantly prolonged the survival of skin allografts in a rat model, with maximum effectiveness achieved through local direct application.
21 citations
,
April 2016 in “International Journal of Oncology” This study found that treatment with the GnRH agonist Triptorelin significantly decreased invasion and expression of S100A4 and CYR61 in certain breast cancer cells, suggesting a potential role in slowing cancer progression.
21 citations
,
April 2021 in “ACS omega” In this study, curcumin was efficiently loaded into PS–PAA nanoparticles at the formation stage, showing even distribution at low concentrations and good biocompatibility with human skin fibroblasts.
21 citations
,
February 2017 in “PLoS ONE” This study found that RhoA influences embryonic stem cell proliferation through the PKN1-cyclin D1 pathway in vitro, suggesting RhoA as a potential target for wound healing therapies.
21 citations
,
August 2014 in “Journal of Cell Communication and Signaling” This study found that Tsukushi facilitates wound healing in mice by regulating macrophage function and myofibroblast differentiation.
21 citations
,
January 2013 in “Annals of dermatology/Annals of Dermatology” In this study, combination therapy with cyclosporine and PUVA for severe alopecia areata resulted in a majority of patients showing only fair to poor responses, though some improvements were noted.
21 citations
,
January 2008 in “Journal of Pediatric Endocrinology and Metabolism” This study found that combined treatment with anastrozole and cyproterone acetate improved the adult height prognosis in testotoxicosis, as observed in two brothers, with good tolerance reported.
21 citations
,
August 1984 in “BJOG An International Journal of Obstetrics & Gynaecology” This study found no differences in ovarian function between renal transplant recipients treated with either cyclosporin A or azathioprine and prednisone, although excessive hair growth was common in both groups.
20 citations
,
October 2003 in “The Journal of Dermatology” This study observed that while dexamethasone-cyclophosphamide pulse therapy is relatively free from hypertension and diabetes compared to conventional steroids in pemphigus patients, it frequently causes generalized weakness and flushing.
20 citations
,
January 2022 in “Oxidative Medicine and Cellular Longevity” This study found that intrinsic reactive oxygen species drive the hair follicle cycle progression through DNA damage and repair, apoptosis, and macrophage polarization, influencing hair loss and regeneration dynamics in mice.
20 citations
,
July 2009 in “Experimental and Clinical Endocrinology & Diabetes” This study found that increased hair growth from Cyclosporin A treatment is likely not due to hormonal changes.