4 citations
,
June 2021 in “Powder Technology” This study developed finasteride-containing granules using a method that improved follicular targeting for androgenic alopecia and reported potential for easy industrial production.
4 citations
,
October 2025 in “Molecules” This study concluded that extracts from fermented pumpkin peel and pulp, processed with Lactobacillus strains and kombucha, may serve as multifunctional cosmetic ingredients, offering antioxidant protection, anti-aging, and skin regeneration benefits by demonstrating cytoprotective effects and reducing inflammatory cytokines in cell assays.
4 citations
,
October 2024 in “Heliyon” This study characterized the CYP154C7 enzyme from *Streptomyces* sp. PAMC26508, highlighting its ability to hydroxylate steroids efficiently, particularly androstenedione, and identified key amino acids important for substrate selectivity and catalytic efficiency.
4 citations
,
March 2024 in “Journal of Investigative Dermatology” SPRY1 deficiency in skin cells causes stem cells to move to the skin surface, leading to increased pigmentation.
4 citations
,
August 2023 in “Nature Communications” In this study, researchers observed that the combination of hair progenitors and their micro-niche changes every three days in mouse zigzag hair, and disruptions in specific genes affected this rhythm, highlighting the importance of this periodic change for normal hair morphology.
4 citations
,
July 2017 in “Archivum Immunologiae et Therapiae Experimentalis” This study observed that patients with recurrent furunculosis had different cytokine profiles compared to healthy subjects and that retinol stimulation altered cytokine secretion in both groups.
4 citations
,
November 2015 in “Research Journal of Medicinal Plant” This study found that ethanolic, aqueous, and hydroethanolic extracts of Tridax procumbens inhibited mitosis and caused mutagenic effects on cell division in Allium cepa root meristematic cells.
4 citations
,
December 2014 in “European Journal of Chemistry” This study synthesized and characterized new 2-hydroxypyrrolidine/piperidine derivatives using FeCl₃·6H₂O as a catalyst, but it reports no biological or clinical results.
4 citations
,
September 2006 in “European Journal of Clinical Pharmacology” This study concluded that finasteride 1 mg does not significantly affect the metabolism of omeprazole in young healthy Japanese male extensive or poor metabolizers for CYP2C19.
4 citations
,
October 2000 in “Contraception” This study found that a regimen combining cyproterone acetate and testosterone buciclate induced reversible azoospermia in bonnet monkeys, highlighting its potential as an effective male contraceptive.
4 citations
,
December 1994 in “PubMed” This study found that treatment with cyproterone acetate and estradiol improved emotional well-being and acceptance of being viewed among women with hirsutism, with no significant differences between oral and transdermal estradiol groups.
4 citations
,
January 1994 in “Journal of hepatology” This study observed that cyclosporine A significantly alters sex hormone levels in both pre- and post-menopausal women with primary biliary cirrhosis.
4 citations
,
January 1992 in “Clinical Oncology” This report describes three cases of hypertrichosis lanuginosa acquisita occurring after cytotoxic chemotherapy for cancer, suggesting a possible relationship which is discussed alongside a review of existing literature.
4 citations
,
January 1991 in “PubMed” The study examined cytokeratin expression in different bovine epithelial tissues, finding that hair follicles and nasolabial glands express both acidic and basic types, while other epithelia express only one type.
4 citations
,
April 1989 in “The Journal of Dermatology” This study observed in mouse skin that trichohyalin granules in hair follicles transform into filamentous structures as inner root sheath cells differentiate and cornify.
4 citations
,
January 1983 in “PubMed” In this case study, a male volunteer with frontal alopecia experienced new hair growth during combined daily treatment with cyproterone acetate and minoxidil, but the new hair was lost after stopping minoxidil.
4 citations
,
April 1955 in “Textile Research Journal” This study found that the extent of reducing agents' effects on hair fibers was linked to the electrode potential of the reagents used.
3 citations
,
July 2020 in “Synthetic and Systems Biotechnology” This study found that the cytochrome P450 enzyme CYP-sb21 can hydroxylate cyclosporine A at multiple positions, reducing its immunosuppressive effects but retaining its hair growth-promoting side-effect, and suggests modifications to improve regioselectivity for commercial use.
3 citations
,
July 2018 in “Biomedicine & pharmacotherapy” This study suggests that paeoniflorin's protective effects on brain astrocytes may be mediated by TSPO and neurosteroids biosynthesis.
3 citations
,
July 1996 in “Clinics in Dermatology” This study found that dietary yeast cell wall supplementation in broiler chickens increased certain immune responses compared to antibiotic treatments following immunization with sheep red blood cells.
3 citations
,
August 2025 in “Advanced Therapeutics” This review explores advancements in cytokine engineering for regenerative medicine, highlighting the development of modified cytokines with enhanced stability and tissue-targeting, potentially improving treatments for chronic wounds and fibrotic diseases by promoting tissue healing and minimizing inflammation, while adapting concepts from cancer immunotherapy.
3 citations
,
September 2024 in “Experimental Dermatology” This study found elevated levels of IL-18 and free IL-18 in hidradenitis suppurativa patients compared to healthy controls, suggesting these cytokines may serve as novel biomarkers for disease activity, with correlations indicating their involvement in disease severity.
3 citations
,
May 2024 in “Amino Acids” This review identifies cysteine's central role in hair growth and its potential impact on Alopecia Areata's pathogenesis, suggesting examination of cysteine metabolism might clarify the disease's underlying mechanisms and lead to new treatments.
3 citations
,
May 2021 in “Genetics and Biodiversity Journal” In this study, the ethanolic extract of Citrullus colocynthis demonstrated strong antioxidant activity and reduced cancer cell numbers in vitro, suggesting potential for pharmacological use.
3 citations
,
April 2017 in “Clinical Drug Investigation” The researchers concluded that after the 2013 EMA recommendation, there was an overall reduction in CPA/EE prescriptions, but no substantial change in patient diagnoses or potential concurrent hormonal contraceptive use.
3 citations
,
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that topical curcumin can initiate hair growth in mice by acting as a JAK inhibitor but could not fully reverse alopecia areata, likely due to insufficient penetration to deeper skin layers.
3 citations
,
July 2015 in “European Journal of Dermatology” This abstract discusses the role of advanced glycation end-products in aging-related skin damage, but does not provide new findings on their impact on alopecia.
3 citations
,
March 2014 in “Journal of Industrial Microbiology & Biotechnology” This study identified a cytochrome P450 enzyme, CYP-pa1 from Pseudonocardia autotrophica, as responsible for the specific hydroxylation of cyclosporin A at the 9th N-methyl leucine, suggesting potential for biotechnological applications.
3 citations
,
January 2005 in “Photochemistry and Photobiology” This study found that overexpression of PKCɛ in mouse epidermis increased sensitivity to metastatic squamous cell carcinoma, suggesting that a PKCɛ-mediated microenvironment may promote cancer development through specific cytokines like TNFα.
3 citations
,
September 1980 in “Experientia” In this study, the pharmacological action of dobutamine on rabbit retinae was found to be distinct from that of other dopamine analogs like apomorphine and N-methyl-dopamine.