research A Case of Vitiligo Combined With Systemic Lupus Erythematosus Treated With Tofacitinib
Tofacitinib successfully treated vitiligo in a patient with lupus without side effects.
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research Novel Advances of Histone Modification in Inflammatory Skin Diseases and Related Treatment Methods
Histone modification is key in treating chronic inflammatory skin diseases.
research The Role of the Skin Microbiome in Wound Healing
The skin microbiome helps heal wounds and can be targeted to improve healing.
research Molecular Heterogeneity of Quiescent Melanocyte Stem Cells Revealed by Single-Cell RNA-Sequencing
Different types of inactive melanocyte stem cells exist with unique characteristics and potential to develop into other cells.
research The Effect of Topical Gel Secretome Hypoxic Mesenchymal Stem Cells on IL-6 and TGF-β Gene Expression in Male Wistar Alopecia-Like Rat Models Induced by Fluconazole
SH-MSCs gel reduced IL-6 and increased TGF-β, suggesting it could treat alopecia.
research Effect of Topical Gel Administration of Secretome Hypoxia Mesenchymal Stem Cells on IL-10 and TNF-α Gene Expression: An In Vivo Experimental Study in Male Wistar Rats with Fluconazole-Induced Alopecia
SH-MSCs gel can effectively treat alopecia by increasing IL-10 and decreasing TNF-α gene expression.
research Epidermal-Dermal Coupled Spheroids Are Important for Tissue Pattern Regeneration in Reconstituted Skin Explant Cultures
Skin spheroids with both outer and inner layers are key for regrowing skin patterns and hair.
research Identification of Distinct Immune Signatures and Chemokine Networks in Scalp Inflammatory Diseases
Different immune responses cause hair loss in scalp diseases, with unique patterns in scalp psoriasis possibly protecting against hair loss.
research Recent Advances in the Genetics of Alopecia Areata
New research has found 14 genes linked to the risk of developing alopecia areata, improving understanding and treatment options.
research Skin Involvement in Systemic Lupus Erythematosus: A Review Article
Skin problems are common in lupus, often appearing first, with various types and treatments, and careful monitoring is important for diagnosis and management.
research IL-17 Axis Is a Significant Driver of Skin Inflammation in CARD14 Mutant Pityriasis Rubra Pilaris Model Mice
Blocking IL-17 can reduce skin inflammation in a mouse model of pityriasis rubra pilaris.
research Alopecia Areata in Children: An Overview of Clinical Features and Recent Treatment Options
New treatments for child hair loss due to immune issues are effective but not yet officially approved.
research Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity: Lessons from Alopecia Areata
ILC1-like cells can cause alopecia areata by attacking hair follicles.
research M-CSF-Stimulated CD11b+ Myeloid Cells Induce Alopecia Areata in C3H/HeJ Mice
M-CSF-stimulated myeloid cells can cause alopecia areata in mice.
research Updates in the Pathogenesis of Alopecia Areata
Alopecia areata is an autoimmune condition causing hair loss, linked to genetic factors and immune system issues, with no cure yet.
research Risk of Autoimmune Diseases in Patients with RASopathies: Systematic Study of Humoral and Cellular Immunity
Patients with RASopathies have a higher risk of autoimmune disorders and should be routinely screened.
research Drug Armamentarium for Alopecia Areata
No cure exists for alopecia areata, and treatments are personalized.
research Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts
Scientists successfully grew mini hair follicles using human skin cells, which could help treat baldness.
research Gynecologic and Hormonal Comorbidities of Scarring Alopecia: A Retrospective Review
Women with scarring alopecia are less likely to have used hormone replacement therapy or oral contraceptives compared to those with female pattern hair loss.
research Skin Morphogenesis by Coupling Biochemical-Bioelectric Signals: Calcium Oscillations Coordinate Dermal Cell Movement by Epidermis-Derived SHH Signaling During Feather Bud Orientation
Calcium signals and SHH guide the direction of feather growth in chicken skin.
research Predictive Modeling of Patient Response to JAK/STAT Inhibitors and Dynamic Patient-Matching
Machine learning can predict how well patients with alopecia areata will respond to certain treatments.
research Dietary Grape Powder Inhibits Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice
Eating grape powder may reduce the severity of skin allergy symptoms.
research Promotion of Hair Growth in Alopecia Areata by Topical Treatment of HDAC Inhibitors
HDAC inhibitors, like Vorinostat and Entinostat, can help regrow hair in alopecia areata.
research Discoid Lupus Erythematosus: Comprehensive Overview and Management
Discoid Lupus Erythematosus often causes scarring hair loss, is influenced by genetics and environment, and requires early treatment to prevent worsening.
research Claudin-1 and Claudin-3 Maintain Proper Hair Follicle Structure and Regulate Telogen Effluvium
Claudin-1 and Claudin-3 are crucial for keeping hair follicle structure and preventing a type of hair loss called telogen effluvium.
research Advanced Age Impairs Self-Renewal and Biases Fate Choice of Hair Follicle Dermal Stem Cells
Older hair follicle stem cells have a reduced ability to renew themselves, leading to more hair loss.
research Aqueous Extract of Mentha Suaveolens Induces Nrf-2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Keratinocyte HaCaT
Mint water extract boosts protective enzymes in skin cells.
research Nicotinic Acid Suppresses Sebaceous Lipid Synthesis of Human Sebocytes via Activating Hydroxycarboxylic Acid Receptor 2 (HCA2)
Nicotinic acid reduces excessive oil production in skin cells by activating a specific receptor, which could help treat acne.
research An Integrated Model of Alopecia Areata Biomarkers Highlights Both Th1/Th2 Upregulation, with Stronger Correlations Between Th2 Activation and Disease Severity
Both Th1 and Th2 immune responses are increased in alopecia areata, with Th2 response more strongly linked to how severe the disease is.
research Orchestrated Cytotoxic and Skin Migratory Ability Lacking Self-Tolerance: Circulating γδT-Cells May Promote Alopecia Areata
The role of γδT-cells in causing alopecia areata remains unclear.