2 citations
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January 2002 This study investigated the pigments and cells causing discoloration in stasis dermatitis but did not clarify the role of melanin or melanocytes in this condition.
August 2024 in “Journal of the American Academy of Dermatology” Nail color change might be an early sign of skin pigmentation from minocycline.
February 2026 in “HCA Healthcare Journal of Medicine” This review discusses identifying keratosis pilaris, its common mimics, and its associated skin diseases across different skin tones but reports no new results.
9 citations
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May 2012 in “PLOS ONE” This study found that integrin-linked kinase is crucial for various epidermal functions, including differentiation and barrier formation, and also plays a previously unreported role in melanocyte development and function.
40 citations
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May 2014 in “PLoS ONE” This study suggests that chronic stress can lead to decreased skin pigmentation in mice by disrupting the skin's HPA axis, potentially making stress a risk factor for depigmentation.
29 citations
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January 2012 in “Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy” This review discusses the various skin, mucosa, and adnexa side effects associated with different chemotherapeutic agents and provides insights into their clinical presentation and management; it reports no new results.
17 citations
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February 2012 in “Cutaneous and Ocular Toxicology” This study found that xerosis and pruritus are prevalent in patients with chronic renal failure undergoing hemodialysis, highlighting the importance of early recognition of skin issues to alleviate discomfort and reduce complications.
16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
June 2026 in “ACS Applied Nano Materials” This study developed and tested a novel microneedle treatment loaded with nanoparticles for vitiligo, leading to enhanced skin repigmentation by targeting immune cells and reducing oxidative stress in a minimally invasive manner.
January 2026 in “Clinical & Translational Oncology” This expert consensus statement highlights that while targeted cancer therapies significantly improve patient survival, they often result in various skin toxicities, underscoring the need for early diagnosis, management, and multidisciplinary care to maintain patients' quality of life and ensure treatment continuity.
May 2024 in “Indian Journal of Dermatology” In this case report, a 22-year-old female was diagnosed with follicular Dowling-Degos disease based on clinical and histological findings, with symptoms including skin lesions confined to hair follicles. The report emphasizes the importance of differentiating this rare variant from similar conditions for proper management.
May 2024 in “Asian Journal of Medical Sciences” This study observed that in patients with primary hypothyroidism, common skin conditions like altered skin texture, dry skin, and diffuse hair loss may emerge before a biochemical diagnosis, suggesting these signs should prompt consideration of hypothyroidism.
July 2026 in “Clinics in Dermatology” This review discusses the potential benefits of topical melatonin in aesthetic dermatology, including its antioxidant and protective properties for skin aging and photoaging, while also noting varying strengths of evidence across different skin conditions.
74 citations
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March 1963 in “Archives of Dermatology” This article reviews historical reports of skin changes, such as pseudoacanthosis nigricans, associated with cholesterol-lowering drugs like triparanol and nicotinic acid, but presents no new clinical findings.
5 citations
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December 1978 in “PubMed” This article reviews the connection between malabsorption syndrome and skin diseases, reporting common skin complications and noting their improvement with malabsorption treatment; it offers no new clinical results.
4 citations
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October 2023 in “Children” This study diagnosed a group of six girls with various ectodermal abnormalities, identifying cranio-skeletal malformations consistent with focal dermal hypoplasia (Goltz syndrome), and found heterozygous mutations in the PORCN gene in two children.
3 citations
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January 2012 in “Journal of cosmetics, dermatological sciences and applications” This descriptive study reported that cutaneous issues, particularly anesthesia and neuropathy dermatitis, were common at saphenous vein harvesting sites in Iraqi patients who underwent coronary artery bypass surgery.
June 2026 in “IECCMEXICO” This review found that dermatological manifestations often indicate systemic diseases, with endocrine-metabolic disorders, autoimmune diseases, and renal or hepatic conditions frequently linked to specific skin changes, highlighting the diagnostic importance of skin examination in internal medicine and endocrinology.
January 2026 in “Journal of Biosciences and Medicines” This research highlights the common and varied skin-related symptoms associated with chronic kidney disease, emphasizing that early recognition and multi-pronged management involving nephrology and dermatology can improve patient outcomes.
January 2012 in “Journal of Investigative Dermatology” The document presented various studies on hair and cutaneous development, revealing insights into hair biology and potential therapeutic targets for hair-related conditions. Key findings included the role of stem cells and their niches in hair regeneration, the impact of TACE/ADAM17 depletion on alopecia, and the expression of somatostatin in hair follicles. Research on genetic factors, such as CYLD mutants and P-cadherin, highlighted their importance in hair growth and pigmentation. Studies on hair aging identified genes involved in hair loss in women over 40. Additionally, the potential of keratinocyte precursors from iPS cells for hair follicle regeneration and the effectiveness of a parathyroid hormone analog in reversing chemotherapy-induced alopecia were explored. The document also discussed the role of cholesterol biosynthesis in cicatricial alopecia, the necessity of Wnt signaling for hair follicle initiation, and the effects of ATP-sensitive potassium channel blockers on hair growth. These findings collectively advanced the understanding of hair growth, alopecia treatment, and skin regeneration.
67 citations
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September 2003 in “Journal of cutaneous pathology” This review discusses the various skin manifestations associated with end-stage renal disease and their potential causes but reports no new clinical findings; the authors emphasize pruritus as a significant condition.
64 citations
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January 2002 in “American Journal of Clinical Dermatology” This review examines the adverse skin reactions associated with antipsychotic medications and reports no new clinical findings, but suggests discussing management strategies to improve patient compliance.
April 2024 in “International Journal of Advanced Research” In this case-control study, researchers observed that vitamin B12 deficiency was significantly associated with diffuse hair loss and muco-cutaneous pigmentation in patients, suggesting these may serve as clinical markers for dermatologists to consider when diagnosing vitamin B12 deficiency.
349 citations
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January 2005 in “The FASEB journal” This review discusses the cutaneous serotoninergic/melatoninergic system's potential role in skin function and resilience against environmental and internal stresses, but does not report new experimental findings.
185 citations
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February 2018 in “Journal of Investigative Dermatology” This review discusses melatonin's potential in dermatology, highlighting its antioxidative, immunomodulatory, and DNA repair properties, but reports no new clinical results.
October 2021 in “Nepal journal of dermatology, venereology & leprology” This review discusses the diverse roles and potential skin health benefits of melatonin, highlighting its anti-inflammatory, antioxidant, and protective effects but reports no new clinical results.
61 citations
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October 2010 in “Postgraduate Medical Journal” This study found that dermatological issues, such as xerosis and pigmentation, are common in chronic kidney disease patients and increase with the severity and duration of the disease, indicating that dialysis often exacerbates these conditions.
1 citations
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October 2020 in “Nepal journal of dermatology, venereology & leprology” This study found that patients on maintenance hemodialysis commonly experience cutaneous symptoms, with pigmentation and nail disorders being the most prevalent.
1 citations
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September 2011 in “UHOD : Uluslararası hematoloji - onkoloji dergisi” This study found no significant differences in age, sex, or histopathological characteristics for differentiating basal cell carcinoma from benign tumors of cutaneous appendages, complicating diagnosis.
March 2018 in “Journal of Pre-Clinical and Clinical Research” Skin problems are common in kidney disease, with dry skin and itching in patients not on dialysis or on hemodialysis, and infections most common in transplant recipients.