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This study found that MPEG-dihexPLA micelles significantly improved the skin deposition of tacrolimus compared to a marketed ointment, suggesting better targeted delivery with reduced systemic absorption.

This study found that penetration enhancer-containing vesicles significantly improved minoxidil delivery to the skin compared to traditional liposomes and penetration enhancer-containing ethanolic solutions, with deformability linked to enhanced deposition.

PEVs effectively deliver minoxidil through skin.

This review discusses emerging drug delivery technologies and formulations for acne and rosacea, noting that microencapsulation enables combining benzoyl peroxide and tretinoin to enhance tolerability and prevention of oxidation.

This review discusses recent advancements in cutaneous drug delivery technologies and the potential of transfollicular pathways for improved treatment of skin conditions, but reports no clinical results.

In this study, researchers suggest that laser-assisted drug delivery could enhance the administration of platelet-rich plasma, and potentially bimatoprost or minoxidil, for patients with androgenetic alopecia by ensuring uniform placement in the dermis without injection pain.

This review explores the formulation, characterization, and applications of microemulsions, highlighting their potential for enhanced cutaneous drug delivery by improving bioavailability and enabling sustained release of both hydrophilic and hydrophobic drugs.

This thesis explored how stratum corneum barrier disruption and pH-sensitive nanoparticles influence drug penetration and release in skin models, highlighting potential applications for treating atopic dermatitis.

ATR12-351 ointment safely delivers LEKTI protein to the skin, reducing enzyme activity in Netherton syndrome.

This study explored the use of spanlastic vesicles to enhance the delivery of bimatoprost for treating alopecia and found that a bimatoprost-loaded nanogel significantly increased skin drug accumulation and improved hair regrowth in a mouse model, outperforming both naive bimatoprost gel and commercial minoxidil formulations.

This study found that polymeric micelle nanocarriers delivered pharmacologically relevant amounts of spironolactone to the epidermis and upper dermis, with higher delivery to pilosebaceous units, suggesting potential for treating glucocorticoid-induced impaired wound healing and pilosebaceous androgen-related skin diseases.

This review examines recent advances in androgenetic alopecia treatment, highlighting how multifunctional plant extracts combined with nanotechnology could improve topical therapy efficacy by enhancing local drug bioavailability and targeting, addressing limitations of existing treatments.

This study found that alginate beads containing monoolein demonstrated promising potential for managing wet wounds by better absorbing excess exudate and delivering adenosine locally, favoring drug localization in damaged porcine skin compared to an aqueous solution without affecting skin viability.

Gene therapy shows promise for improving wound healing, but more research is needed for human use.

This review explores how microneedles can improve the delivery of dermatological treatments by bypassing the skin's outer barrier, discussing their potential use in managing skin diseases, cosmetic applications, and challenges related to clinical adoption.

In this review, bioengineered materials incorporating growth factors and cytokines were reported to enhance wound healing by sustaining drug delivery, reducing dosage, and minimizing side effects compared to traditional treatments.

This review highlights the significant impact of cutaneous and oral mucosal adverse events on patients undergoing breast cancer treatment, emphasizing the need for early detection and comprehensive management to maintain treatment adherence and enhance patient care.

This study found that niosomes significantly enhanced the skin deposition of retinoic acid while reducing its permeation, outperforming other tested nanoformulations.

This review explores the potential of cell-mediated drug delivery systems in dermatology, highlighting their ability to target inflamed or diseased skin while discussing applications in diseases like atopic dermatitis and melanoma, along with challenges such as immunogenicity and manufacturing.

INTASYL is a promising, adaptable RNAi technology for treating skin cancers.

This article reviews advanced strategies for enhancing drug delivery to cutaneous stem cells to improve treatment for skin conditions and reports no new experimental findings.

This study found that using Labrasol® in phospholipid vesicle formulations improved minoxidil's skin delivery and local accumulation, showing potential for treating hair growth disorders.

This study found that 40 nm nanoparticles can effectively penetrate into hair follicles and epidermal Langerhans cells in human skin samples, potentially enabling efficient transcutaneous vaccine delivery.

This source provides an overview of quercetin's therapeutic capabilities in skin wound healing, highlighting its antioxidant and anti-inflammatory benefits but noting its poor solubility limits skin penetration; various delivery strategies have been explored to enhance its effectiveness.

This study found that econazole nitrate delivered via MPEG-dihexPLA micelles significantly increased skin deposition compared to Pevaryl® cream, potentially enhancing drug bioavailability and clinical efficacy.

In an animal model, this study found that PEG hydrogels delivering M2 macrophage-derived exosomes effectively promoted M1 to M2 macrophage transition and enhanced wound healing.

In this study, itraconazole was shown to accumulate in the deeper skin layers of guinea pigs after oral administration, suggesting this delivery method effectively targets infective organisms there.

This study found that topical alpha-terthienyl combined with UVA radiation rapidly induced dose-dependent cutaneous photosensitization in guinea pigs, suggesting potential for photochemotherapy in skin disorders without future carcinogenic risks.

This study evaluated a new nanogel formulation containing Ciclopirox Olamine for treating cutaneous candidiasis, finding that the optimized version offered improved skin penetration, sustained drug release, and effective antifungal action against Candida albicans compared to conventional treatment.