February 2025 in “International Journal of Cosmetic Science” This study found that treating hair with ATS, formed from fumaric acid and cysteamine, effectively improved hair quality by increasing moisture content and altering the internal structure of strong curls.
35 citations
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November 2021 in “Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology” This study identified dynamic changes in DNA methylation associated with different growth stages in Tan sheep, which may offer insights to retain their valuable curly fleece as they age.
34 citations
,
August 2002 in “British Journal of Dermatology” This study observed that two patients treated with interferon α-2b and ribavirin for chronic hepatitis C experienced complete and reversible straightening of their natural curly hair, which recurred with treatment resumption.
18 citations
,
March 1992 in “Archives of Dermatology” This case report presents a 28-year-old man with scarring alopecia unresponsive to topical treatments, alongside a family history of keratosis pilaris and unique curly scalp hair.
15 citations
,
October 2016 in “Journal of dermatological treatment” This paper reviews the literature on acquired trichorrhexis nodosa, a clinical hair loss diagnosis associated with hair care practices, particularly in those with tightly curled hair, and emphasizes management through protective hair care regimens rather than traditional prescription therapies.
9 citations
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July 2021 in “Dermatology and Therapy” This review highlights promising recent advances in therapies for epidermolysis bullosa, including gene therapy and stem cell approaches, but reports no definitive cures and emphasizes the need for further research.
9 citations
,
September 2016 in “Plastic and reconstructive surgery. Global open” In this study, a curved nonrotary punch was found to achieve the lowest follicular unit transection rates of less than 5% compared to conventional rotary punches in hair transplantation for patients with tightly curled Afro-textured hair.
7 citations
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January 2013 in “Indian Journal of Plastic Surgery” This study found that beard and body hair can be used as additional donor sources for scalp transplants in androgenic alopecia, retaining their original color, curl, and calibre.
In this summary, the researchers describe the Brazilian keratin treatment as a popular hair-straightening process that originated in Brazil in 2003 and has since gained global traction, particularly for smoothing and straightening curly or frizzy hair through a keratin-based product and heat application.
January 2026 in “Dermatology Research and Practice” In this cross-sectional study of Saudi Arabian citizens, researchers found that increased frequency of shampooing improved the condition of both hair and scalp, with long and curly hairstyles being more prone to breakage and daily hair loss.
September 2025 in “Indian Journal of Dermatology” In this case report, researchers detailed a 22-year-old Turkish woman diagnosed with autosomal recessive woolly hair/hypotrichosis (ARWH/H), linked to a mutation in the LIPH gene, resulting in sparse, poorly growing, curly hair, highlighting the need for genetic consideration in similar hair conditions.
In this study, researchers found that the keratin-associated protein 36-1 gene (KRTAP36-1) allele C is linked to variations in mean fibre curvature of fine wool in Chinese Tan lambs, suggesting its role in their distinctive curly coat.
This research explores the use of serial block-face scanning electron microscopy to model the complex architecture of sheep wool fibres, focusing on the role and distribution of para- and ortho-cortical cells in determining wool curliness, though the mechanism remains unclear.
January 2023 in “Springer eBooks” This review discusses the causes, characteristics, and current management strategies for epidermolysis bullosa, emphasizing that while experimental therapies show promise, there are no definitive cures.
This article reviews a clinical case of pseudofolliculitis, highlighting its chronic nature, commonality in individuals with curly hair, and suggests management strategies, but reports no new clinical results.
April 2020 in “International Journal of Cosmetic Science” This study found that improved protein extraction methods enhanced the resolution of hair proteins on gels, but differences in protein abundance between curly and straight Japanese women’s hair were minimal and unlikely to affect hair structure.
September 2022 in “IP Indian journal of clinical and experimental dermatology” This review discusses treatments for androgenetic alopecia, recommending Minoxidil, Finasteride, and Dutasteride as first-line therapies, and highlights the potential of JAK inhibitors for future permanent cures.
This study examined hair classification based on geo-racial origin, observing that Caucasian and Mediterranean hair differs morphologically from African or Asian hair, with differences in density, thickness, and fiber shape contributing to varied hair characteristics such as color and curliness.
43 citations
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January 1970 in “Acta Medica Scandinavica” This study found that obese patients experienced similar weight loss on a very low-calorie diet and total fast, but the diet was associated with fewer complications.
3 citations
,
January 2002 in “Springer eBooks” This study found that using cationic and non-ionic polymers during alkaline hair relaxer treatments may help strengthen hair and control swelling, potentially reducing damage.
July 2024 in “Journal Archives of Health” This study reviewed the medical literature on generalized woolly hair and reported that while there are no effective treatments, some narratives suggest that topical Minoxidil may help with hypotrichosis associated with the condition.
40 citations
,
June 2013 in “Journal of cosmetic dermatology” This review discusses the widespread use of Brazilian keratin treatments and notes that many contain formaldehyde, marketed as safe despite potential safety concerns, but reports no new clinical results.
9 citations
,
May 2021 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study suggests that topical minoxidil may be a promising treatment for isolated autosomal recessive woolly hair due to LIPH mutations, although effective treatments are not yet established.
In this review of permanent hairstyles like perms, the authors discuss the chemical processes involved and highlight potential risks such as hair and scalp damage, emphasizing the need for careful client assessment and safe application techniques to mitigate these risks.
December 2025 in “Frontiers in Medicine” This review details the global mutation patterns of genes associated with autosomal recessive woolly hair/hypotrichosis and highlights potential, yet unproven, treatments like minoxidil and regenerative therapies, reporting no new clinical results.
66 citations
,
October 2003 in “Dermatologic clinics” Excision and laser techniques can effectively treat acne keloidalis nuchae.
September 2019 in “University of the Arts London Research Online (University of the Arts London)” This study tested the effects of protective pre-treatments on African hair and found that these treatments, combined with moderate grooming, may help maintain cuticle integrity.
February 2022 in “Fibers” This study found that a sucrose-based crosslinker can effectively straighten hair and maintain durability in high humidity and through repeated washings without affecting the hair's tensile properties or causing surface damage.
252 citations
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November 1995 in “The EMBO Journal” Blocking EGFR in mice causes hair loss and skin changes.
109 citations
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June 2000 in “Development” This study reports that activating Notch signaling in the hair follicle cortex of transgenic mice caused abnormal differentiation of the medulla and cuticle, highlighting potential cell-cell interactions.