26 citations
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April 2021 in “Materials & Design” This study found that composite chitosan nanofibers containing luminescent europium complexes can sensitively detect Cu2+ concentrations as low as 10 μmol/L, making them suitable for use in biological systems.
1 citations
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January 2025 in “Molecules” This review reported that while glycyl-L-histidyl-L-lysine tripeptide copper complex (GHK–Cu) has limited skin permeation when used alone, liposomes may enhance its absorption, but there is limited research on this aspect, highlighting a need for further studies.
25 citations
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January 2024 in “International Journal of Nanomedicine” The hydrogel is safe, reduces oxidation, and helps heal wounds effectively.
May 2026 in “Scientific Reports” This study found that a bioactive borosilicate glass containing Sr and Cu ions exhibited promising mechanical strength, biocompatibility, and antibacterial activity, particularly the CuSr-1 wt.% composition, suggesting potential for use in orthopedic implants and bone tissue engineering.
13 citations
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March 2010 in “International Journal of Cosmetic Science” This study used nanoscale secondary ion mass spectrometry to locate where calcium and copper are concentrated in colored hair, finding these metals particularly in the cuticle's sulfur-rich regions.
12 citations
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September 2023 in “Polymers” This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.
2 citations
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January 1987 in “Acta Agriculturae Scandinavica” This study found that subcutaneous injections of certain chelators led to skin and hair depigmentation, increased skin elasticity, and disturbed hair growth in minks, without affecting fur quality.
1 citations
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December 2023 in “Nanomaterials” In this study, the researchers synthesized copper-doped mesoporous silica nanoparticles and observed that they enhance tumor microenvironment regulation and, when paired with disulfiram, effectively kill cancer cells while also showing synergistic anti-tumor effects with immune checkpoint inhibitors.
1 citations
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July 2025 in “Advanced Science” This study developed multifunctional microneedle patches with CTB nanozymes that successfully eradicated MRSA infections in wounds by combining near-infrared laser-induced nitric oxide release and local hyperthermia, while also regulating oxidative stress, inflammation, and angiogenesis through specific signaling pathways.
June 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study evaluated petroleum jelly-based bioactive glass ointments with varying copper concentrations for wound healing in chronic wound models, finding that the 3 wt% copper formulation significantly improved healing by enhancing tissue regeneration, vascularization, and antibacterial protection compared to controls.
April 2024 in “Materials today bio” In this study, the researchers developed a novel wound dressing incorporating copper-doped calcium silicate and curcumin, which significantly promoted nerve and blood vessel regeneration in deep burn wounds, emphasizing the crucial role of bioactive chelation in neuralized skin repair.
May 2026 in “Bioactive Materials” This study reported that in degenerative alopecia, Zn²⁺/Cu²⁺-dependent proteases are downregulated and destabilized, and a specially developed microneedle patch reactivated these enzymes, reduced senescence, and enhanced hair regeneration in an animal model.
242 citations
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January 2000 This study identified a strong association between heavy metal contamination in drinking water and chronic diseases like renal failure and liver cirrhosis in Great Cairo Cities, Egypt.
45 citations
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February 2011 in “IOP Conference Series Materials Science and Engineering” This study developed a sensor that effectively measures Tl+ cation in solutions with a wide dynamic range and low detection limit, responding linearly within the concentration range 1.0 × 10−8 to 1.0 × 10−1M.
8 citations
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January 2024 in “Regenerative Biomaterials” This study found that a novel bioceramic/alginate hydrogel with photothermal properties and multiple ion release effectively reduces infection and inflammation, and enhances osseointegration in early-stage peri-implant lesions, potentially improving dental implant survival rates.
324 citations
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July 2020 in “Applied Water Science” This study found high levels of toxic heavy metals in water sources of mining communities in Abakaliki, Nigeria, posing potential health risks including Parkinson's and Alzheimer's diseases.
165 citations
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January 2008 in “Journal of biomaterials science. Polymer ed.” This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.
30 citations
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June 2006 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, oral zinc sulphate was found to cause hair hypopigmentation and significantly inhibit eumelanogenesis in mice.
7 citations
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October 2019 in “Evidence-based Complementary and Alternative Medicine” This meta-analysis found that traditional Chinese medicine may be an effective and safe adjuvant therapy for androgenetic alopecia, improving efficacy rates and symptom scores compared to conventional medicine.
3 citations
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June 2019 in “Journal of Bangladesh Society of Physiologist” This study found that patients experiencing hair loss had significantly lower serum levels of zinc and copper compared to healthy controls.
3 citations
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November 2014 in “Protein Expression and Purification” This study reported successful recovery of biologically active recombinant murine Wnt3a without detergent, suggesting usefulness for structure-activity studies avoiding detergent-related issues.
September 2024 in “African Journal of Biomedical Research” This study found that individuals with alopecia areata had significantly lower blood levels of vitamin D and slightly lower serum copper levels compared to healthy controls, suggesting the potential importance of assessing these factors in the chemical evaluation of patients with this condition.
January 2019 in “Applied Organometallic Chemistry” The compound (NH4)2Mn0.17Cu0.83Cl4.2H₂O has a specific structure, shows weak magnetism at low temperatures, and undergoes phase changes at high temperatures.
165 citations
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February 2014 in “Phytotherapy Research” Myrtle has various health benefits and potential for medicine development.
130 citations
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June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that estrogen receptor beta, not alpha, is the main mediator of estrogen action in human skin and hair follicles, suggesting a distinct role in these tissues.
112 citations
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November 2023 in “Nano-Micro Letters” This review discusses the developments over the past five years in nanozyme-based theranostics for tumor therapy, including their classification, design, and synergistic strategies. It also outlines the challenges and prospects of using nanozymes to enhance selectivity, biosafety, repeatability, and stability in therapeutic applications.
93 citations
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November 2018 in “Carbohydrate Polymers” This study demonstrated that modified montmorillonites combined with bacterial cellulose enhanced antimicrobial, wound healing, and tissue regenerative activities in a burn mice model, suggesting potential as an artificial skin substitute for burn patients.
86 citations
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January 2008 in “Journal of nutritional & environmental medicine” This review examines the health benefits of green tea, focusing on catechins, but reports no new findings; the authors emphasize potential benefits for conditions like cancer, heart disease, and diabetes.
85 citations
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July 2025 in “Nature Communications” This review examines the evolving field of nanozymes, highlighting their unique properties and biocatalytic capabilities that challenge traditional concepts of biocatalysis, with implications for sustainable applications and potential roles in physiological processes and disease pathogenesis.
76 citations
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August 2018 in “International Journal of Cosmetic Science” This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.