Search

for
Search:

Glossary Crystallography

scientific study of atomic arrangements in crystalline solids

Crystallography is the scientific study of the arrangement of atoms in crystalline solids. By using techniques like X-ray diffraction, scientists can determine the precise structure of crystals, which is crucial for understanding material properties and designing new drugs.

Related Terms

Sort by

Research

30 / 1000+ results

Hyaluronic Acid Microneedles Enhance Transdermal Delivery of Minoxidil Derivatives with 1,2,4-Oxadiazole-5-One Unit for Effective Hair Regeneration: Insights from X-Ray Crystallography and Animal Models

research Hyaluronic acid microneedles enhance transdermal delivery of minoxidil derivatives with 1,2,4-oxadiazole-5-one unit for effective hair regeneration: Insights from X-ray crystallography and animal models

October 2025 in “Journal of Molecular Structure”

Hyaluronic acid microneedles help deliver minoxidil derivatives effectively for hair regrowth.

research Hair keratin molecular dynamics studies

December 2016 in “RepositóriUM (Universidade do Minho)”

This review discusses molecular dynamics studies of hair keratin, highlighting newly developed computational models that replicate experimental phenomena and offering insights into molecular mechanisms.

research Crystal Structure of 17-.BETA.-Benzoyloxy-16-.BETA.-methylpregna-4,6-diene-3,20-dione.

February 1999 in “Analytical Sciences”

A new antiandrogen compound was made and its detailed three-dimensional shape was described.

research Study the Structure and Dynamics of Antifungal Agent Ketoconazole by CSA and Site-Specific Spin-Lattice Relaxation Time Measurements

March 2021 in “Research Square (Research Square)”

This study analyzed the structure and dynamics of ketoconazole, revealing how its molecular characteristics, such as spin-lattice relaxation time and chemical shift anisotropy, are influenced by π-π stacking interactions and different carbon site environments.

research Structural characterization of polymorphs and molecular complexes of finasteride

17 citations , January 1999 in “Journal of Molecular Structure”

This study determined the molecular structure of finasteride and its related crystalline forms, highlighting different hydrogen-bond interactions and structural configurations in various crystalline complexes.

research Aromatic C-nitrosation of a bioactive molecule. Nitrosation of minoxidil

8 citations , January 2011 in “Organic and Biomolecular Chemistry”

Minoxidil reacts to nitrosation 7 times more than phenol, mainly due to its -NH₂ groups, leading to the creation of N-nitrosominoxidil.

Minoxidil/Salicylic Acid Hydrogel Formulated for Alopecia Treatment: Supramolecular Interactions Modulate Physicochemical Properties and Biological Activities

research Minoxidil/salicylic acid hydrogel formulated for alopecia treatment: Supramolecular interactions modulate physicochemical properties and biological activities revealed by experimental and theoretical studies

February 2024 in “Journal of Molecular Structure”

In this study, researchers developed a supramolecular hydrogel combining minoxidil and salicylic acid, finding that it accelerates hair growth and enhances hair follicle regeneration in vivo, suggesting its potential as an effective treatment for alopecia.

Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family

research Structural & functional studies of L-PGDS and SMPDL3A enzymes in lipid signaling family

October 2019

This study explored the structure and function of lipocalin prostaglandin D synthase, revealing its dual role in substrate catalysis and as a lipophilic ligand carrier, potentially informing future drug delivery design.

research Structural Study of Polymorphs and Solvates of Finasteride

61 citations , April 2007 in “Journal of Pharmaceutical Sciences”

This study reported new crystallographic structures and polymorphs of finasteride, including several solvates with distinct X-ray diffraction patterns and thermally characterized properties.

17α-Acetoxy-6-Bromo-16β-Methylpregna-4,6-Diene-3,20-Dione: A New Steroidal Derivative with High Antiandrogenic Activity

research 17α-Acetoxy-6-bromo-16β-methylpregna-4,6-diene-3,20-dione

December 1998 in “Acta Crystallographica Section C-crystal Structure Communications”

This study describes the molecular conformation and intermolecular interactions in the crystalline structure of the compound C24H31BrO4.

research Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization

24 citations , July 2017 in “Structure”

In this study, researchers found that ligand homodimerization controls the receptor binding specificity of the FGF9 subfamily, preventing off-target activation of FGFR "b" isoforms.

research Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase

20 citations , March 2013 in “Journal of Lipid Research”

This study examined the structural and biochemical mechanisms of human lipocalin prostaglandin D synthase, detailing substrate and product binding processes at the catalytic site and suggesting potential for drug delivery targeting hydrophobic molecules.

research Crystal Structure and Synthesis of 17α-Acetoxy-4-bromopregn-4-ene-3,20-dione

August 2002 in “Analytical Sciences”

The document concludes that a compound with potential for treating prostate cancer and hair loss was successfully made and its detailed structure was confirmed.

research Crystal Structure of Minoxidil

5 citations , January 2004 in “Analytical Sciences X-ray Structure Analysis Online”

This structural study reports on the crystal properties of a compound used for treating alopecia, revealing different conformations and nitrogen hybridization in its piperidine rings.

research Hair keratin molecular dynamics models

March 2016 in “RepositóriUM (Universidade do Minho)”

Molecular dynamics simulations help understand keratin's properties and predict hair's response to treatments.

research Further errors in polymorph identification: furosemide and finasteride

19 citations , July 2006 in “Acta crystallographica”

This study determined that previous reports mistakenly identified different polymorphs of furosemide and finasteride, which are actually identical, due to incomplete data collection in single-crystal X-ray diffraction analysis.

research Structures of three polycystic kidney disease-like domains fromClostridium histolyticumcollagenases ColG and ColH

18 citations , February 2015 in “Acta Crystallographica Section D: Structural Biology”

This study reports that Ca 2+ binding alters the dynamics and surface properties of PKD-like domains in Clostridium histolyticum collagenases, enhancing their stability and potentially aiding in collagen-targeting vehicle development.

High-Resolution Structures of Mutants Affecting Access to the Ligand-Binding Cavity of Human Lipocalin-Type Prostaglandin D Synthase

research High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase

5 citations , July 2014 in “Acta Crystallographica Section D-biological Crystallography”

This study reports that mutations in human L-PGDS affect the entrance and exit of ligands in its binding cavity, suggesting these residues play a role in ligand interaction processes.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

This study reports the synthesis and structural characterization of a novel dinuclear platinum(III) complex with potential antitumor and catalytic activity.

Crystallization and Preliminary X-Ray Analysis of the Human Androgen Receptor Ligand-Binding Domain with a Coactivator-Like Peptide and Selective Androgen Receptor Modulators

research Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators

1 citations , November 2008 in “Acta crystallographica”

This study reports the crystallization of the human androgen receptor's ligand-binding domain with nonsteroidal ligands, which may aid in understanding the differences in binding compared to steroidal ligands.

Evaluation of Polymorphism Influence in Finasteride

research Evaluation of Polymorphism Influence in the Finasteride

August 2014 in “Acta Crystallographica”

This study found that the dissolution profiles of different finasteride polymorphs may affect the quality of finasteride capsules, highlighting the need for polymorphic quality control.

research Crystal Structure of 3-Oxo-4-Aza-5-Alpha-Androstone-17 β-Tert-Butyl Carboxamide with an O···H–(C, N) Acceptor Four-Center Hydrogen Bond

2 citations , December 2008 in “Journal of Chemical Crystallography”

This study reports the crystal structure and geometric parameters of a modified Finasteride derivative, highlighting significant differences in dihedral angles compared to its solvated analog and computational models.

research Water distribution in human hair microstructure elucidated by spin contrast variation small-angle neutron scattering

1 citations , June 2023 in “Journal of applied crystallography”

This study utilized the DNP–SANS technique on human hair for the first time and found significant changes in the SANS profile dependent on polarization conditions, providing insights into the structural composition and dynamic properties of keratin and its associated proteins.

research Crystal Structure and Synthesis of 17α-Acetoxy-pregn-4,6-diene-3,20-dione

June 2010 in “Journal of Chemical Crystallography”

This study determined the crystal structure and conformation of synthesized 17x-Acetoxy-pregn-4,6-diene-3,20-dione, revealing specific molecular interactions and structural details in an orthorhombic crystal system.

$Limits of Visual Detection for Finasteride Polymorphs in Prepared Binary Mixtures: Analysis by X-ray Powder Diffraction$

research Limits of Visual Detection for Finasteride Polymorphs in Prepared Binary Mixtures: Analysis by X‐ray Powder Diffraction

5 citations , September 2014 in “Journal of Pharmaceutical Sciences”

research Attempted construction of minoxidil: carboxylic acid cocrystals; 7 salts and 1 cocrystal resulted

66 citations , February 2010 in “CrystEngComm”

Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.

research Chapter 17. Selective androgen receptor modulators (SARMs)

18 citations , January 2001 in “Annual Reports in Medicinal Chemistry”

This chapter reviews selective androgen receptor modulators, discussing their therapeutic potential beyond current androgen applications, and reports no new clinical findings.

research Investigation of intermolecular interactions in finasteride drug crystals in view of X-ray and Hirshfeld surface analysis

16 citations , July 2015 in “Journal of Molecular Structure”

This study comprehensively compared different crystalline forms of finasteride, including the new finasteride DMF solvate hemihydrate, to better understand their structural characteristics and intermolecular interactions.

research Direct access to novel chromeno-pyrimidine-N-oxides via tandem base catalyzed double nucleophilic addition/dehydration reaction

7 citations , March 2013 in “Tetrahedron Letters”

This study reports a new one-pot method for synthesizing chromeno-pyrimidine-N-oxides with high yield from 4-chloro-3-formylcoumarin and aromatic carboximide oximes, confirmed by X-ray analysis.

research Alternative synthesis of the anti-baldness compound RU58841

4 citations , January 2014 in “RSC Advances”

A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.