August 2025 in “The Journal of Sexual Medicine” This retrospective pharmacovigilance study identified 34 drugs, including finasteride and dutasteride, that may be associated with sexual dysfunction, with a higher risk observed in males aged 31-45.
98 citations
,
December 2015 in “The Journal of Cell Biology” In this study, researchers found that the absence of type I or type II keratins in mice leads to severe skin barrier defects, highlighting keratins' crucial role in epidermal structure and function.
23 citations
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April 2003 in “Journal of Structural Biology” Keratin structure changes during keratinization, but the exact model remains uncertain.
10 citations
,
January 2010 in “International journal of trichology” This study found that keratin-associated proteins form part of the developing exocuticle and a-layer in hair fiber cuticle cells, while cornified envelope proteins were absent.
96 citations
,
October 2021 in “Reproductive Sciences” Women with PCOS often experience depression and anxiety, affecting their quality of life.
9 citations
,
May 2025 in “Stem Cell Research & Therapy” This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.
3 citations
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January 2023 in “Indian Dermatology Online Journal” This study reported a series of mild to moderate cutaneous adverse drug reactions following COVID-19 vaccination, predominantly after Covishield, with only one requiring hospitalization.
This study investigated the effects of pathological α-synuclein on sebaceous gland cells in Parkinson's disease, finding that α-synuclein exposure altered cellular differentiation and lipid production, suggesting a potential link between α-synuclein and lipid dysregulation in the skin of PD patients.
In this study, nearly two-thirds of Saudi adults reported experiencing hair loss following COVID-19 infection or vaccination, with female sex and nutritional deficiencies identified as significant correlates for this condition.
February 2026 in “International Journal of Molecular Sciences” In this study, researchers identified 47 proteins associated with male pattern baldness severity and prioritized five candidate genes, including druggable CD38, suggesting new non-hormonal targets for therapeutic development.
February 2026 in “Journal of Family Medicine and Primary Care” This study highlights the link between stress-induced hair loss and stress levels among university students, emphasizing the need to address stress to support their wellbeing and academic achievement.
July 2025 in “Journal of Education Health and Sport” This review found that androgenetic alopecia may be associated with increased risks of cardiovascular disease, metabolic disorders, and mental health impacts, suggesting its potential as a biomarker for systemic conditions.
March 2025 in “Frontiers in Plant Science” This study highlights the ZmNF-YC1-ZmAPRG pathway as a potential mechanism to improve maize tolerance to phosphorus deficiency, emphasizing its role in modulating lipid and photosynthetic activity, although direct impacts on root adaptations remain unclear (Bai et al., 2024).
5 citations
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December 2023 in “Current Biology” A feedback loop between LRH and RSL4 controls root hair growth in Arabidopsis.
99 citations
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July 2005 in “Ultramicroscopy” This study analyzed the nanotribological properties of various hair types and human skin, revealing differences in friction and adhesion based on ethnicity and hair condition.
February 2026 in “Journal of the American Academy of Dermatology” In this study, researchers characterized the clinical features of ophiasis, an uncommon type of alopecia areata, and proposed a new subtype classification that may help predict treatment response and guide management, noting that ophiasis generally has a chronic and refractory nature.
July 2025 in “JAAD Case Reports” A thorough assessment and combined treatment are crucial for managing complex alopecia, especially in patients with skin of color.
March 2025 in “Journal of Controlled Release” This study found that a biocomposite microneedle system, which includes selenium nanozyme and hypoxic extracellular vesicles, enhanced hair density and follicle diameter in androgenetic alopecia mice by fighting inflammation, promoting blood vessel growth, reducing reactive oxygen species, and counteracting androgen effects.
May 2023 in “Journal of Ethnopharmacology” In this study, Allium macrostemon Bunge extract was found to promote hair regrowth in a testosterone-induced androgenetic alopecia mouse model by activating Wnt/β-catenin signaling and boosting hair dermal papilla cell proliferation and growth factor expression.
1 citations
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August 2021 This study found that biomimetic dermal papilla spheres cultured in a specific microenvironment can partially restore hair-inducing ability in high-passage dermal papilla cells in nude mice, resembling the characteristics of primary cells.
24 citations
,
June 2020 in “Industrial Crops and Products” This study reports that biomass activated carbon fibers derived from metaplexis japonica seed hair effectively adsorb methylene blue dye, demonstrating high capacity and rapid adsorption performance.
21 citations
,
January 2018 in “PLoS Genetics” This study found that certain keratin gene mutations associated with pachyonychia congenita are linked to altered enamel structure and increased risk of dental caries.
44 citations
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December 1991 in “Annals of the New York Academy of Sciences” This study observed that epidermal growth factor and fibroblast growth factor have distinct roles in sheep skin, with EGF involved in differentiation and FGF in bulb proliferation and fiber growth.
47 citations
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May 1995 in “Journal of Investigative Dermatology” Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.
July 2023 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, the authors propose that drugs like trazodone and antipsychotics such as chlorpromazine, which can induce priapism, may help restore libido synaptic circuits, offering potential treatment for post-finasteride syndrome and post-SSRI sexual dysfunction.
This research concluded that the novel hydrogel PlacMA, derived from human placenta and curable by visible light, shows promise for cell culture and tissue engineering applications due to its tunable properties.
42 citations
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January 2018 in “Expert review of precision medicine and drug development” This review discusses the integration of drug repurposing with personalized medicine through off-label prescribing and reports no new results, highlighting the potential for systematic exploration using omics technologies.
105 citations
,
February 1996 in “Journal of biological chemistry/The Journal of biological chemistry” In this study, sequences upstream of the TGM3 gene were found to regulate epithelial-specific gene expression in keratinocytes, suggesting potential applications in gene therapy.
36 citations
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November 2019 in “Molecular biology and evolution” This study suggests that the keratins found in reptile and bird skin appendages evolved independently from mammalian hair keratins, highlighting convergent evolution in these species.
30 citations
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December 2017 in “Advanced Healthcare Materials” This study reports that using nanogel and layer-by-layer self-assembly to encapsulate single dermal papilla cells can form cell spheroids that regenerate hair follicles successfully in a hair follicle regeneration model.