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      Treatment of Invasive Aspergillosis with Itraconazole

      research Treatment of invasive aspergillosis with itraconazole

      350 citations , June 1989 in “The American Journal of Medicine”
      This study suggests that itraconazole may significantly improve therapy for aspergillosis, with 12 out of 15 evaluable patients responding to the treatment.
      The Rotterdam Study: 2016 Objectives and Design Update

      research The Rotterdam Study: 2016 objectives and design update

      336 citations , August 2015 in “European Journal of Epidemiology”
      This article reviews the design and objectives of the Rotterdam Study, as well as summarizes major findings, without reporting new results.
      Prospect of Stem Cell Conditioned Medium in Regenerative Medicine

      research Prospect of Stem Cell Conditioned Medium in Regenerative Medicine

      298 citations , January 2014 in “BioMed Research International”
      This review discusses various methods for obtaining stem cell-derived conditioned media and its applications in disease treatment, finding generally positive results but highlighting the need for standardized production methods.
      The Rotterdam Study: 2014 Objectives and Design Update

      research The Rotterdam Study: 2014 objectives and design update

      266 citations , November 2013 in “European Journal of Epidemiology”
      This article outlines the rationale and design of the Rotterdam Study, summarizes its major findings, and updates its objectives and methods; it reports no new research results.
      The Rotterdam Study: 2012 Objectives and Design Update

      research The Rotterdam Study: 2012 objectives and design update

      247 citations , August 2011 in “European Journal of Epidemiology”
      This article outlines the rationale, design, major findings, and updated objectives of the ongoing Rotterdam Study, without presenting new research data.
      Melatonin

      research MELATONIN

      220 citations , August 1988 in “Clinical endocrinology”
      This review provides a comprehensive overview of melatonin's physiological roles, effects, and clinical implications, but it does not present new experimental findings.
      The Rotterdam Study: 2010 Objectives and Design Update

      research The Rotterdam Study: 2010 objectives and design update

      219 citations , September 2009 in “European journal of epidemiology”
      This article discusses the rationale, design, major findings, and updated objectives and methods of the ongoing Rotterdam Study on various diseases, without reporting new research results.
      Interferon Alfa-2a in the Treatment of Cutaneous T Cell Lymphoma

      research Interferon alfa-2a in the treatment of cutaneous T cell lymphoma

      209 citations , March 1989 in “Journal of The American Academy of Dermatology”
      This study found that recombinant human leukocyte interferon alfa-2a achieved a 64% overall antitumor response rate in patients with early and advanced cutaneous T cell lymphoma and was generally well-tolerated.
      COVID-19 and Sex Differences: Mechanisms and Biomarkers

      research COVID-19 and Sex Differences

      185 citations , August 2020 in “Mayo Clinic Proceedings”
      This review discusses biological sex differences in COVID-19 outcomes and reports no new clinical results; it identifies a need for studies to clarify how sex influences disease progression.
      Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension

      research Minoxidil — An Alternative to Nephrectomy for Refractory Hypertension

      180 citations , July 1973 in “The New England Journal of Medicine”
      In this study, minoxidil effectively reduced blood pressure to near normal levels in patients with malignant or accelerated hypertension resistant to conventional treatments, offering a potential alternative to nephrectomy.
      Clinical Manifestations of Toxic Shock Syndrome

      research Clinical Manifestations of Toxic Shock Syndrome

      176 citations , August 1981 in “JAMA”
      This study reported that toxic shock syndrome, originally noted in children, is now predominantly associated with menstruating women, with some experiencing recurrence and complications like vocal cord paralysis and impaired finger sensation.
      Wound Healing and the Use of Medicinal Plants

      research Wound Healing and the Use of Medicinal Plants

      170 citations , September 2019 in “Evidence-based Complementary and Alternative Medicine”
      This review discusses the use of 36 medicinal plant species for cutaneous wound healing and reports no new clinical results; the authors highlight the potential for these traditional practices to inform modern therapies.
      Hirsutism and Acne in Polycystic Ovary Syndrome

      research Hirsutism and acne in polycystic ovary syndrome

      169 citations , August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology”
      This article discusses treatments for hirsutism and acne in women with polycystic ovary syndrome, suggesting that lower doses of current medications maintain efficacy while reducing cost and side effects, but reports no new clinical results.
      Endocrinology of Transgender Medicine

      research Endocrinology of Transgender Medicine

      166 citations , October 2018 in “Endocrine Reviews”
      This review discusses the effects of hormonal treatments on the physical and mental health of transgender individuals, reporting significant reductions in mental health issues following treatment, but calls for more research on long-term and nonbinary outcomes.
      The Pharmacology of Methotrexate

      research The pharmacology of methotrexate

      155 citations , August 1991 in “Journal of The American Academy of Dermatology”
      This article reviews methotrexate's pharmacokinetics and toxicity, emphasizing the role of urinary excretion and leucovorin in avoiding most toxic reactions; it provides no new clinical results.
      Hormone Therapy for Transgender Patients

      research Hormone therapy for transgender patients

      146 citations , December 2016 in “Translational Andrology and Urology”
      This review discusses the creation of transgender-specific guidelines by WPATH and the Endocrine Society, based mostly on clinical experience, and reports no new results.
      WNT Signaling in Disease

      research WNT Signaling in Disease

      144 citations , August 2019 in “Cells”
      This review discusses the WNT signaling pathway's involvement in human diseases and highlights recent advances in WNT-related treatments, but it presents no new research findings.
      Lupus Erythematosus: Systemic and Cutaneous Manifestations

      research Lupus erythematosus: systemic and cutaneous manifestations

      144 citations , September 2006 in “Clinics in Dermatology”
      This article outlines manifestations of systemic lupus erythematosus, noting rapid joint symptom improvement with corticosteroids and antimalarial drug responsiveness for skin symptoms, and links anti-Ro with photosensitive rash and subacute lupus.