140 citations
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January 2021 in “Journal of the International Society of Sports Nutrition” This source reports that while creatine supplementation is popular for improving muscle mass and performance, questions about its efficacy and safety persist. An expert team is reviewing literature to address concerns like water retention, renal effects, and its benefits across different populations and uses.
1 citations
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May 2023 in “Farmacja Polska” This study summarizes current knowledge on the role of creatine in the human body, its applications in supplementation, and its impact on muscle mass, especially noting that animal-based foods are primary dietary sources and that women may experience health benefits from supplementation.
April 2025 in “Journal of the International Society of Sports Nutrition” In this study, creatine supplementation over 12 weeks showed no effect on androgen levels or hair follicle health in healthy young males, challenging the belief that creatine causes hair loss.
36 citations
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October 2015 in “Journal of Cosmetic Dermatology” In this study, a new apple stem cell extract serum significantly improved signs of skin aging and enhanced cell metabolism in human senescent fibroblasts, showing visible effects after one week of use.
1 citations
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November 1987 in “Journal of The American Academy of Dermatology” Isotretinoin can raise CPK levels, so patients need monitoring, especially before surgery.
April 2026 in “NSUWorks (Nova Southeastern University)” This review concludes that creatine monohydrate is a safe and effective supplement, offering potential health benefits beyond athletic performance; however, it addresses concerns regarding its use among specific populations and effects on various health aspects.
April 2023 in “Tikrit Journal of Pharmaceutical Sciences” In this study, researchers assessed the effects of deferasirox in 85 children with ß-thalassemia in Kirkuk and reported that while 55.3% experienced a reduction in serum ferritin, 9.4% had adverse effects, indicating that deferasirox is generally well-tolerated as an iron chelator with modifiable side effects.
September 2025 in “International Journal of Research in Medical Sciences” This study found that breast cancer treatment with chemotherapy, radiotherapy, and/or hormonal therapy led to a significant increase in blood urea and creatinine levels, indicating nephrotoxicity among non-diabetic, non-cardiac post-menopausal patients with infiltrating ductal carcinoma.
December 2024 in “Journal of the International Society of Sports Nutrition” In this narrative review, researchers examined common misconceptions and questions about creatine monohydrate, addressing issues such as its potential effects on muscle benefits without exercise, interactions with caffeine, inflammatory properties, safety during pregnancy, and effects on adolescents, among others.
December 2023 in “Pakistan Journal of Medical & Health Sciences” This study found that in South Asian women with PCOS, the severity of non-alcoholic fatty liver disease is strongly linked to early renal dysfunction, as indicated by increased serum creatinine and urinary albumin levels, and reduced eGFR.
55 citations
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August 2012 in “Resources and Environment” This study found that landfill leachates from Olusosun and Aba-Eku in Nigeria can cause liver and kidney dysfunction in Wistar rats, potentially posing a health risk through chemical exposure.
37 citations
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October 2017 in “Clinical and Experimental Dermatology” This article discusses the potential of oral tofacitinib as a treatment for atopic dermatitis, alopecia areata, and vitiligo, without presenting new clinical results.
20 citations
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February 2023 in “American Journal of Clinical Dermatology” In this study, 40.9% of patients taking 4 mg baricitinib and 21.2% taking 2 mg achieved significant hair regrowth over 52 weeks, indicating potential long-term benefits for adults with severe alopecia areata without introducing new safety concerns.
15 citations
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May 2022 in “Fermentation” This study found that fermented camel milk containing 50% pumpkin seed milk significantly improved oxidative stress markers in rats and enhanced sensory and physicochemical properties compared to untreated groups.
15 citations
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September 2013 in “Pharmaceutical Biology” This study found that Zizyphus jujuba fruit aqueous extract may reduce nephrotoxicity caused by ibuprofen in rats by lowering serum urea and creatinine and improving kidney antioxidant enzyme activities.
14 citations
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December 2022 in “Frontiers in Pharmacology” This study reports that negative pressure wound therapy combined with PRP may effectively accelerate wound healing and reduce mortality in diabetic foot ulcers, with albumin and age identified as independent predictors of mortality risk.
11 citations
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January 2016 in “BMC veterinary research” This study found that urinary selenium to creatinine ratio and serum selenium concentrations quickly respond to changes in dietary selenium, making them useful biomarkers for assessing selenium status in dogs.
11 citations
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January 2013 in “Revista Brasileira De Terapia Intensiva” This article reports a case of rhabdomyolysis in a patient two hours after consuming the freshwater fish Mylossoma duriventre, suggesting a possible link to Haff disease from an unidentified toxin.
10 citations
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June 2024 in “American Journal of Clinical Dermatology” This review highlights that while sonidegib and vismodegib offer promising treatment options for advanced basal cell carcinoma, their use is often limited by treatment-emergent adverse events, which can be managed through protocol modifications and supportive interventions.
3 citations
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February 2010 in “Clinical kidney journal” This case report highlights a severe kidney injury linked to the combined use of ciclosporin and simvastatin in a patient treated for alopecia universalis.
2 citations
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January 2014 in “Chinese medicine” This study found that the polyherbal cough syrup Linkus reduced cough reflexes without causing observed toxicity in rats, suggesting it may be an effective and safe option.
2 citations
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June 2007 in “PubMed” This study found that alopecia in young calves was associated with a higher incidence of diarrhoea and prolonged ruminal acidosis, with significant changes in blood chemistry noted.
2 citations
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April 2023 in “Curēus” This study presents a case of a 24-year-old man who developed mild transaminitis and rhabdomyolysis within 24 hours of starting valproic acid for seizures, with symptom resolution following drug cessation.
1 citations
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October 2024 in “Journal of the American Society of Nephrology” This case study highlights the risks of ingesting topical minoxidil, demonstrated by a 24-year-old male who accidentally consumed 1500mg due to a language barrier, leading to a temporary rise in creatinine levels but no lasting kidney damage.
1 citations
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November 2023 in “Journal of ovarian research” In this study involving rats with letrozole-induced polycystic ovary syndrome, Agaricus subrufescens significantly reduced blood glucose, total cholesterol, testosterone levels, and renal markers, suggesting its potential protective effects on both metabolic and reproductive parameters.
1 citations
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January 2021 in “Acta Cirurgica Brasileira” This study found that both finasteride and dutasteride led to morphological and functional kidney damage in rats, with more severe effects observed in the dutasteride group.
January 2026 in “Springer Link (Chiba Institute of Technology)” In this study, researchers synthesized silver nanoparticles using an extract from Mitracarpus scaber and found them to have significant hepatoprotective and anti-hyperplastic effects in rats, suggesting potential for treating liver injury and benign prostatic hyperplasia.
January 2026 in “E3S Web of Conferences” This study found that silver nanoparticles synthesized using Mitracarpus scaber extract showed potential hepatoprotective and anti-hyperplastic effects in rats, suggesting novel therapeutic strategies for managing liver injury and benign prostatic hyperplasia.
July 2025 in “Journal of Research in Siddha Medicine” This study investigated the sub-acute toxicity of Eclipta alba extract in Wistar albino rats, finding generally comparable hematological and biochemical parameters to controls, but noted mild morphological liver and kidney changes at the highest dose, highlighting a key area for further safety research.
January 2025 in “Indian Journal of Biochemistry and Biophysics” This study found that the uric acid to creatinine ratio had excellent diagnostic ability for polycystic ovary syndrome, with significant associations to metabolic and hematologic changes in PCOS patients.