Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that using spanlastics, a nano, surfactant-based drug delivery system, improved the bioavailability, drug release characteristics, and pharmacokinetic behavior of famotidine, a poorly soluble drug, by enhancing its dissolution and membrane permeation.

This meta-analysis reports that trastuzumab deruxtecan is effective and has an acceptable safety profile for treating HER2-low or positive advanced breast cancer, although further research is recommended to support individualized treatment strategies.

This study found that PC 3DP models are reliable preclinical tools that could potentially customize treatment strategies and predict patient prognoses by correlating drug sensitivity profiles with clinical outcomes, though larger patient cohort validation is needed to confirm clinical utility.

This study found that transgender or gender-nonconforming youth experience higher odds of sleep disorders compared to cisgender peers, but gender-affirming therapy may reduce these odds.

This study developed a genetic toolbox to engineer Cutibacterium acnes for dermal applications, successfully creating a strain that secretes antioxidants to reduce oxidative stress in a UV stress model.

This review highlights emerging strategies to manage chemotherapy side effects like nausea, neuropathy, and alopecia, noting that scalp cooling has been effective for reducing hair loss, while cryotherapy and cannabis show promise but need further study for side effect management.

This database provides detailed physiological parameters of porcine skin to enhance the MPML MechDermA Model, improving dermal absorption predictions for human studies in the Simcyp Simulator.

This article discusses the increasing trend of retargeting existing drugs for new indications and emphasizes the need for additional support in drug development, without reporting specific new results.

In this survey study, participants from scalp cooling Facebook groups reported benefiting from shared experiences, instructions, insurance advice, and product recommendations, although only a minority sought dermatologist consultations, suggesting these groups provide a significant informational platform for chemotherapy-induced alopecia patients.

This abstract describes a program with various presentations and events focused on Canadian excellence in rheumatology but reports no new research findings.

This study found that Medicare patients with benign prostatic hyperplasia had high adherence to 5-alpha reductase inhibitor therapy, which was associated with a reduced risk of needing surgical intervention.

This review examines the role of adipose-derived stem cells in cancer treatment, particularly for hepatocellular carcinoma, and reports mixed preclinical and clinical findings, underscoring the need for further research.

This study found that astilbin downregulates effector CD4+ T cell activities through the CYP1B1/ROS/PPARγ pathway, suggesting its potential use in treating inflammation.

This registry-based analysis observed rapid growth in hair-loss clinical trials between 2015 and 2025, highlighting regional concentration, prevalent therapeutic categories, and diverse outcome reporting while emphasizing the need for standardization and broader representation.

This study analyzed hair-loss clinical trials from 2015 to 2025 and found that, while the number of registrations increased globally, research activity was concentrated in certain regions and varied in therapeutic approaches and outcome specifications.

This study analyzed the cost-effectiveness of scalp cooling as a means of preventing chemotherapy-induced hair loss and found it to be financially reasonable compared to dermatologic management strategies, suggesting that it should be considered for routine insurance coverage due to its cost-effectiveness.

This review assesses the potential of smart dressings, engineered to respond to various stimuli, as advanced treatments for chronic inflammatory skin diseases by examining their activation mechanisms and proposing future developments like integrating AI and closed-loop monitoring for adaptive therapy.

Finasteride and dutasteride's effects are mainly due to target binding saturation and slow enzyme turnover.

This study reviews current pharmacological treatments for alopecia, highlighting minoxidil, 5α-reductase inhibitors, JAK inhibitors, and other agents, and notes ongoing research aimed at improving their effectiveness and safety profiles.

This narrative review examined the efficacy and safety of topical tretinoin for various dermatological conditions, finding strong support from robust trials for acne and photoaging, while indicating potential benefits for other uses like melasma and alopecia, yet highlighted the need for more standardized, high-quality trials.

This review highlights the limitations of existing hair loss treatments like minoxidil and finasteride and suggests that future therapies may benefit from focusing on antibody and cell-based treatments, which offer targeted and potentially transformative options for managing hair loss disorders.

This study found that in patients with genetic generalized epilepsies, certain gene variants were linked to differences in valproic acid treatment outcomes, including a higher likelihood of treatment failure, varying serum drug concentrations, and specific side effects like weight gain and hair loss.

This study identified seven novel CYP17A1 inhibitor scaffolds as potential leads for treating polycystic ovary syndrome through an in silico approach, demonstrating favorable interactions, drug-like properties, and predicted bioactivities warranting further experimental validation.

This review identified two promising therapeutic targets for drug repurposing to treat refractory angina in patients with angina pectoris without obstructive coronary artery disease: endothelin-1 receptor blockers and soluble guanylate cyclase stimulators.

In this case report, a patient required more local anesthetic than usual for hair transplant surgery, which the authors suggest may be due to cannabis use impacting pain sensitivity and anesthetic clearance.

This study found that for managing early-onset androgenetic alopecia in men, minoxidil monotherapy is cost-effective at a $50,000 willingness-to-pay threshold, while combining minoxidil with platelet-rich plasma becomes cost-effective at a $100,000 threshold.

This article describes the Dermatologic Surgery journal, which publishes comprehensive, peer-reviewed information on cosmetic and reconstructive skin surgery, but offers no new research findings.

This case report discusses a 32-year-old man's treatment for advanced androgenetic alopecia using a combination of topical minoxidil and oral finasteride, but no clinical outcomes are detailed.

In this study, researchers developed and tested a gel containing apocynin-loaded nanoparticles that showed promising results in treating rheumatoid arthritis in rats, suggesting potential for novel topical treatments in inflammatory conditions.

Lasers can effectively treat pseudofolliculitis barbae, but insurance often doesn't cover it, possibly due to racial bias.