research Perforins Expression by Cutaneous Gamma Delta T Cells
This review explores the expression of Perforin by gamma delta T cells in human skin and its role in cytotoxicity but reports no new experimental results.
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research Long-Term Response of Hirsutism and Other Hyperandrogenic Symptoms to Combination Therapy in Polycystic Ovary Syndrome
This study found that in women with PCOS, suppressive therapy using spironolactone plus oral contraceptives improved hirsutism more effectively than either treatment alone, with initial scores predicting success.
research Endoplasmic reticulum in health and disease: the 12th International Calreticulin Workshop, Delphi, Greece
This workshop reviewed various roles of endoplasmic reticulum chaperones, including calreticulin, in cellular signaling, disease states, and potential markers, but reports no new experimental findings.
research Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata
This study found that intracellular Toll-like receptors were significantly up-regulated in peripheral blood mononuclear cells of alopecia areata patients, suggesting a potential role in inflammatory signaling and pathogenesis.
research COVID-19 in Africa: an ovarian victory?
This review discusses how high estrogen levels in African women might contribute to lower COVID-19 rates and fatalities, reports no new clinical results, and suggests considering these factors for future pandemics.
research The Role of PGC-1α in Aging Skin Barrier Function
In this review, researchers explored how PGC-1α might improve aged skin barrier function by influencing mitochondrial function and reducing inflammation, factors that are linked to epidermal health during aging.
research Genetic variants in AR and SHBG and resistance to hormonal castration in prostate cancer
In this study, researchers reported that the SHBG +5790 G>A polymorphism was associated with an increased risk of developing resistance to hormonal castration in advanced prostate cancer patients.
research Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells
This study found that a mixture of plant extracts significantly improved skin barrier function, reduced inflammation, and exhibited anti-aging effects in human skin cells.
research Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19
This study suggests that women with polycystic ovary syndrome may have an increased risk of COVID-19-related cardiac and renal complications, and that weight loss through lifestyle changes could help reduce these risks.
research Epithelial loss of mitochondrial oxidative phosphorylation leads to disturbed enamel and impaired dentin matrix formation in postnatal developed mouse incisor
This study found that mitochondrial oxidative phosphorylation in epithelial cells is necessary for proper enamel formation and odontoblast differentiation in developing incisor teeth in K320E-Twinkle Epi mice.
research Vitamin D Receptor gene polymorphisms taq-1 and cdx-1 in female pattern hair loss
This study found that certain VDR gene polymorphisms are more prevalent in female pattern hair loss patients than in healthy controls, suggesting these polymorphisms may increase disease risk.
research Investigation on antimicrobial, antioxidant, and anti-cancerous activity of Agaricus bisporus derived β-Glucan against cervical cancer cell line
In this study, Agaricus bisporus derived β-Glucan particles demonstrated antimicrobial, antioxidant, and anticancer effects against cervical cancer HeLa cells, suggesting potential as a therapeutic option.
research COVID-19 vaccination related exacerbations of hair loss in patients with moderate-to-severe alopecia areata on systemic therapy
This review discusses vaccine safety concerns for individuals with autoimmune and inflammatory conditions, noting vaccine hesitancy due to observed exacerbations post-vaccination and a lack of comprehensive trial data.
research Role of the Wnt signaling pathway in keratoacanthoma
This study concluded that the Wnt signaling pathway does not significantly influence human keratoacanthoma development, but the overexpression of Sox9 suggests alternate signaling involvement.
research Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism
This study found that bacterially induced metabolic changes in stem cells can enhance skin and hair follicle regeneration in both mice and humans, suggesting potential strategies for improving recovery after injury.
research Alopecia Areata
This review discusses recent advances in understanding alopecia areata's disease mechanisms and highlights JAK molecules as promising therapeutic targets, but reports no new clinical results; controlled trials are needed.
research Case of follicular mucinosis: Nestin‐expression in mucin‐producing cells
This case report describes a 29-year-old Japanese man with follicular mucinosis, suggesting nestin-positive, multipotent hair follicle stem cells may be involved in reticular epithelial degeneration of the outer root sheath.
research Salivary Inflammatory Markers and Free Androgen Index in Women with Polycystic Ovary Syndrome: A Case-Control Study
In this study, women with PCOS exhibited a significantly elevated low-grade inflammatory profile through salivary cytokines, with IL-1β and TNF-α demonstrating strong potential as non-invasive diagnostic markers, alongside traditional androgen measures like FAI.
research rs4541843 G > A variant near miR-182 is associated with susceptibility, severity, and increased hsa-miR-182-5p expression in alopecia areata
In this study, the rs4541843 G > A variant was found to be significantly associated with increased risk and severity of alopecia areata, as well as elevated expression of hsa-miR-182-5p, suggesting their potential as molecular markers for diagnosis and severity assessment.
research Correlations between soluble receptor for advanced glycation end products and heme oxogenase-1 in post-COVID-19 patients with telogen effluvium
This study found that post-COVID-19 telogen effluvium is strongly associated with elevated oxidative stress marker sRAGE and reduced antioxidant marker HO-1, suggesting potential biomarkers for early diagnosis and monitoring.
research Myrtus communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing
This study found that Myrtus communis leaf extract significantly decreased IL-1α and increased VEGF gene expressions in human keratinocytes, which may relate to the plant's traditional uses for hair loss and wound healing, though further research is needed to explore these effects.
research Integrative Nutritional Mechanisms of Keyora Lycopene 23 in 1 Man's Multi-Vitamin in Erectile Dysfunction, Male Infertility, Prostatic Disorders, and Metabolic Dysregulation
This study found that the Keyora Lycopene 23 in 1 formulation may improve various aspects of male endocrine and reproductive health by targeting oxidative stress, nitric oxide deficiency, and hormonal imbalance.
research Integrative Nutritional Mechanisms of Keyora Lycopene 23 in 1 Man's Multi-Vitamin in Erectile Dysfunction, Male Infertility, Prostatic Disorders, and Metabolic Dysregulation
In this study, the researchers introduced the Keyora Lycopene 23 in 1 formulation, demonstrating its potential to improve male endocrine and reproductive health by addressing oxidative stress, nitric oxide deficiency, androgen imbalance, and mitochondrial dysfunction through a comprehensive multi-nutrient approach.
research The Effect of Ferritin, Vitamin D, and Some Hormonal and Biochemical Parameters on Patients with Female-pattern Hair Loss after COVID-19 Infection
This study found that women experiencing hair loss after recovering from COVID-19 had significantly lower Vitamin D and ferritin levels and higher testosterone and triglyceride levels compared to those without hair loss, indicating a potential link between these factors and the condition.
research Supplemental figure 2 from Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate
In this study, the combined treatment of ursolic acid and resveratrol was evaluated for its effects on skin tumor promotion in female FVB mice. The combination was applied topically before TPA treatment and was found to significantly inhibit TPA-induced epidermal hyperproliferation, signaling pathways, and skin inflammation more effectively than either compound alone. Key signaling pathways affected included EGFR, STAT3, and NF-κB, among others. The combination also increased tumor suppressor levels and reduced proinflammatory cytokine expression. Overall, the combined treatment resulted in a greater reduction in tumor multiplicity and size, highlighting its potential as a more effective strategy for inhibiting skin tumor promotion compared to individual treatments.
research Supplemental figure 2 from Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate
In this study, the combined treatment of ursolic acid and resveratrol was evaluated for its inhibitory effects on skin tumor promotion in female FVB mice. The combination was applied topically before TPA treatment and was found to significantly inhibit TPA-induced epidermal hyperproliferation, signaling pathways, and skin inflammation more effectively than either compound alone. Key signaling pathways affected included EGFR, STAT3, and NF-κB, among others. The combination also increased tumor suppressor levels and reduced proinflammatory cytokine expression. Overall, the combined treatment resulted in a greater reduction in tumor multiplicity and size, highlighting its potential as a more effective strategy for preventing skin tumor promotion compared to individual treatments.
research The Potential Application of Ecklonia cava Extract in Scalp Protection
This study found that Ecklonia cava extract increased skin hydration and decreased redness, suggesting potential benefits for protecting and repairing scalp skin from pollutant-induced damage.
research Abstracts from the ASA 40thAnnual Meeting
This special issue contains abstracts from the ASA 40th Annual Meeting, providing an overview of various studies without reporting new primary results.
research The pathogenesis of alopecia areata
In this study, researchers found that alopecia areata is linked to immune cell activation against hair follicle autoantigens and is associated with heart changes and cardiac marker alterations in humans and mice.
research Skin Care Properties of Grape Seed Polyphenols, a By-Product of the Winery Industry
This article discusses the historical and current uses of grape seeds in various industries but reports no new research findings.