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Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Thyroid hormone may be useful for treating various skin conditions and needs more research.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

The document concludes that proper diagnosis and FDA-approved treatments for different types of hair loss exist, but treatments for severe cases often fail and future improvements may focus on hair follicle stem cells.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

Don't combine abiraterone and spironolactone for prostate cancer treatment as it may worsen the disease.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

The S250C variant in a gene may cause autoimmunity and immunodeficiency by impairing protein function.

The study suggests that people with rosacea are more likely to have chronic rhinosinusitis.

Testosterone therapy can help improve sexual function, mood, and bone density in women with low androgen levels, but more research is needed on long-term safety.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

Finasteride may help treat chronic CSC, improving vision.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

Skin symptoms are important for diagnosing and managing juvenile-onset systemic lupus erythematosus and usually get better with treatment.

Accurate diagnosis is key for treating different kinds of hair loss, and immune response variations may affect the condition and treatment results.