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    Glossary Corticotropin-Releasing Hormone

    peptide hormone that triggers stress response via ACTH release

    Corticotropin-Releasing Hormone (CRH) is a peptide hormone involved in the stress response. It is produced by the hypothalamus and stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH), which in turn prompts the adrenal glands to produce cortisol, a key stress hormone. CRH also plays a role in various bodily functions, including immune response and skin health, and has been linked to conditions like alopecia, where stress can exacerbate hair loss.

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    Research 30 of 601

    1. Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes Proceedings of the National Academy of Sciences · 2002 · 284 citations
    2. Corticotropin releasing hormone and the skin Frontiers in bioscience · 2006 · 137 citations
    3. An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess Endocrinology · 2013 · 27 citations
    4. New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP<sub>3</sub>‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75<sup>NTR</sup>and TrkA) in<i>ex vivo</i>human male androgenetic scalp hair follicles British Journal of Dermatology · 2020 · 12 citations
    5. Increased CRHR1 expression on monocytes from patients with AA enables a pro‐inflammatory response to corticotrophin‐releasing hormone Experimental Dermatology · 2024 · 3 citations
    6. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells Annals of Medicine · 2025
    7. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    8. Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells 2025
    9. Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells iScience · 2024
    10. Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus? Postepy Dermatologii I Alergologii · 2017
    11. Corticotropin releasing factor-1 receptor antagonism associated with favorable outcomes of male reproductive health biochemical parameters Frontiers in Endocrinology · 2023
    12. Corticotropin-Releasing Factor Down-Regulates Hair Growth-Related Cytokines in Cultured Human Dermal Papilla Cells Journal of the Society of Cosmetic Scientists of Korea · 2014 · 1 citations
    13. The human skin as a hormone target and an endocrine gland Hormones · 2004 · 146 citations
    14. Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies Experimental Dermatology · 2020 · 15 citations
    15. Stress Hormone and Skin Disease InTech eBooks · 2011 · 2 citations
    16. Hormonal acne: leading to a paradigm shift in the management of acne Expert Review of Dermatology · 2013
    17. The Hormonal Background of Hair Loss in Non-Scarring Alopecias Biomedicines · 2024
    18. Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol The FASEB Journal · 2005 · 489 citations
    19. Neuroimmunoendocrine circuitry of the ‘brain-skin connection’ Trends in Immunology · 2005 · 293 citations
    20. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA<sub>A</sub>Receptors Journal of Neuroscience · 2011 · 248 citations
    21. Neuroendocrinology of the hair follicle: principles and clinical perspectives Trends in Molecular Medicine · 2014 · 98 citations
    22. Neuroendocrine Perspectives in Alopecia Areata: Does Stress Play a Role? Journal of Investigative Dermatology · 2009 · 69 citations
    23. Stress-related skin disorders Reviews in Endocrine and Metabolic Disorders · 2016 · 67 citations
    24. The Skin POMC System (SPS): Leads and Lessons from the Hair Follicle Annals of the New York Academy of Sciences · 1999 · 66 citations
    25. “Sebocytes’ makeup” - Novel mechanisms and concepts in the physiology of the human sebaceous glands 2011 · 58 citations
    26. Hair melanocytes as neuro-endocrine sensors—Pigments for our imagination Molecular and cellular endocrinology · 2005 · 43 citations
    27. New approach to the understanding of keloid: psychoneuroimmune&ndash;endocrine aspects Clinical Cosmetic and Investigational Dermatology · 2015 · 21 citations
    28. The human hair follicle has established a fully functional peripheral equivalent of the hypothamalic‐pituitary‐adrenal‐axis (HPA) Experimental Dermatology · 2005 · 9 citations
    29. The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells BMC Molecular and Cell Biology · 2020 · 9 citations
    30. An implication for post-transcriptional control: Reciprocal changes of melanocortin receptor type 2 mRNA and protein expression in alopecia areata Medical Hypotheses · 2010 · 7 citations