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The document concludes that treating tough skin disease in lupus involves sun protection, steroids, antimalarials, and various other therapies chosen based on individual risks and benefits.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

Recent genetic insights show that low-renin hypertension includes a range from essential hypertension to secondary or familial forms, affecting diagnosis and treatment.

Alopecia areata is an autoimmune hair loss condition treated with corticosteroids, and histologic confirmation is the best diagnosis method.

SHBG binding properties are unchanged in male liver cirrhosis patients.

Monochromatic light devices, especially the 308-nm excimer laser, are promising for treating alopecia areata but more research is needed.

Testosterone replacement may help post-menopausal women with androgen insufficiency, but more research is needed on its benefits and risks.

COVID-19 can cause skin issues like chilblains and rashes, which may help in early detection, especially in patients without other symptoms.

Regenerative therapies show promise for treating vitiligo and alopecia areata.

Antidepressants might help with skin inflammation and improve conditions like psoriasis and eczema.

Topical clobetasol is recommended over mycophenolate mofetil for treating Lichen Planopilaris due to better safety and patient satisfaction.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

Deoxycholic acid is effective for reducing chin fat but can cause side effects and serious complications, so careful patient evaluation is needed.

Intralesional therapy for keratoacanthoma is effective and has fewer side effects than systemic treatments.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Mesotherapy might help reduce fat in specific areas for those close to their ideal weight, but more research and care are needed to ensure safety.

The study found that Central Centrifugal Cicatricial Alopecia mainly affects middle-aged African descent women, is linked to certain hair care practices and genetics, and often goes undiagnosed for years.

Toxic Epidermal Necrolysis is a rare, serious skin condition that can affect anyone, is more common in women, and may be linked to genetics, with a 20% mortality rate mainly due to sepsis.

Some treatments like methotrexate with prednisone might help juvenile morphea, but more research is needed to confirm.

Some skin conditions are common during pregnancy and can be safely treated without affecting the pregnancy outcome.

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

Activating ER-β, not ER-α, improves skin cell growth and wound healing.

Treatment can improve survival and symptoms in dogs with Cushing's disease, but outcomes are unpredictable.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Interferons are effective for some skin conditions and cancers, but can have side effects and need more research for optimal use.

Transgender patients need proper skin care, especially when undergoing hormone treatments, to manage issues like acne and hair loss.

The combination of cyclosporine and PUVA might help treat severe alopecia areata.