research Cell Cycle Regulation and Regeneration
Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.
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research Facts and Ideas from Anywhere
Obesity in the U.S. is largely influenced by diet and exercise, certain medications can improve heart procedures and hair growth, and major teaching hospitals have better patient outcomes.
research Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets
Understanding how EDC genes are regulated can help develop better drugs for skin diseases.
research Circle Hairs in a Patient with Multiple Myeloma
An elderly woman with cancer improved after treatment for a rare skin condition with coiled hairs.
research Efficient In Vitro Transfection of Human Keratinocytes with an Adenovirus-Enhanced Receptor-Mediated System
The study investigated three nonviral transfection systems for gene transfer in human keratinocytes, with a focus on the adenovirus-enhanced receptor-mediated (AVET) system. The AVET system showed superior efficiency, achieving a transfection rate of 28.8%, compared to lower rates with SuperFect and no success with PrimeFector. The presence of adenovirus was crucial for effective gene delivery. The study also found that slowly adhering keratinocytes were transfected more effectively, suggesting stem cells were less efficiently transfected. The AVET system was able to correct the enzymatic defect in keratinocytes from lamellar ichthyosis patients, but was unsuccessful in organotypic cultures due to barriers like the cornified layer. Overall, the AVET system was a powerful tool for transient in vitro transfection of keratinocytes, with potential applications in gene therapy for skin diseases.
research Decay of Skin-Specific Gene Modules in Pangolins
Pangolins have lost some skin-related genes, but kept others, leading to their unique scales and skin features.
research Convergent Decay of Skin-Specific Gene Modules in Pangolins
Pangolins have lost some skin-related genes, but kept others, showing complex skin evolution.
research Characterization of the Epidermal-Dermal Junction in hiPSC-Derived Skin Organoids
The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.
research Keratinocytes Regulate the Function of Melanocytes
Keratinocytes control how melanocytes work.
research Establishment of Keratinocyte Cell Lines from Human Hair Follicles
Scientists created keratinocyte cell lines from human hair that can differentiate similarly to normal skin cells, offering a new way to study skin biology and diseases.
research Epidermal Keratinocyte Stem Cells: Their Maintenance and Regulation
Skin stem cells are maintained by signals from nearby cells and vary in their ability to renew and mature.
research Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain During Epidermal Differentiation
Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.
research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer
TGM3 is important for skin and hair structure and may help diagnose cancer.
research Epidermal Stem Cell Diversity and Quiescence
Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.
research The Histopathologic Spectrum of Psoriasis
Psoriasis skin changes are complex and might need several biopsies for a clear diagnosis.
research Cell Death in the Skin: Mechanisms and Implications
Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.
research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation
TCDD speeds up skin barrier formation by increasing certain gene expressions.
research A Unique Clinicopathological Manifestation of Fungal Infection: A Case Series of Deep Dermatophytosis in Immunosuppressed Patients
Early treatment of superficial fungal infections in immunocompromised patients is crucial.
research MicroRNAs in the Skin: Role in Development, Homeostasis, and Regeneration
MicroRNAs are important for skin health and could be targets for new skin disorder treatments.
research Developing Stratified Epithelia: Lessons from the Epidermis and Thymus
The skin and thymus develop similarly to protect and support immunity.
research Notoedric Mange in Free-Ranging Masked Palm Civets (Paguma Larvata) in Japan
Some masked palm civets in Japan have a skin disease caused by mites.
research Preparing the Hair Follicle Canal for Hair Shaft Emergence
A specific type of skin cell creates an opening for hair to grow out, and problems with this process can lead to skin conditions.
research Majocchi's Granuloma in a High School Wrestler
A high school wrestler's skin rash was cured with antifungal medication after a misdiagnosis and incorrect treatment led to a fungal infection.
research Structure and Development of the Skin and Cutaneous Appendages
Understanding skin structure and development helps diagnose and treat skin disorders.
research Dental Management in a 7-Year-Old Child with Ichthyosis Vulgaris: A Rare Case Report
Dentists should start preventive treatments early for children with Ichthyosis Vulgaris to avoid dental problems.
research Vitamin D Metabolism and Function in the Skin
Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.
research Vitamin D and the Skin: Physiology and Pathophysiology
Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.
research Development and Homeostasis of the Skin Epidermis
The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
research Eph/Ephrin Signaling in Epidermal Differentiation and Disease
Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.
research Congenital Hair Loss Disorders: Rare, But Not Too Rare
Some hair loss disorders are caused by genetic mutations affecting hair growth.