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This review discusses the formation and structure of the cornified cell envelope in the epidermis, highlighting biochemical pathways and genetic factors, but presents no new experimental results.

In this study, researchers found that the absence of type I or type II keratins in mice leads to severe skin barrier defects, highlighting keratins' crucial role in epidermal structure and function.

This study explored gene expression in Changthangi goats and found that higher expression of keratin-related genes and specific signaling pathways may play a role in the development of Pashmina fiber.

This study found that lysine carboxymethyl cysteinate helps protect the epidermis from UVB-induced damage by activating autophagy and restoring cornification processes in a skin model.

This study found that keratin-associated proteins form part of the developing exocuticle and a-layer in hair fiber cuticle cells, while cornified envelope proteins were absent.

This study found that Nrf2 activation protected keratinocytes from UVB damage but also caused thickening, inflammation, and cysts, limiting its therapeutic potential for skin protection.

This study analyzed the cornified envelope of epidermal proteins, finding keratins dominate, which may help explain the minimal impact of deleting genes for single envelope components in congenital ichthyosis.

This study found significant changes in gene expression related to skin structure and signaling pathways in AEC syndrome skin, offering new insights into the syndrome's molecular underpinnings.

This study identified Sciellin, a new protein precursor to the cornified envelope in keratinocytes, with unique solubility properties hinting at its potential role in envelope assembly.

This review discusses the chemical stability of protein envelopes found in the epidermis and other stratified squamous epithelia, but reports no new clinical results.

TG5 helps maintain hair follicle health, while TG3 aids in hair shaft development.

This study identified biallelic variants in the LSS gene as a possible genetic cause of palmoplantar keratoderma-congenital alopecia syndrome type 2, highlighting the role of cholesterol synthesis in skin cornification.

This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.

This study suggests that human hair follicle cells and epidermal keratinocytes differ in their degree of keratinization and other characteristics when cultured on mixed collagen membranes.

This review discusses the role of epidermal differentiation complex genes and epigenetic mechanisms in skin development and certain diseases, emphasizing their potential for improving drug development and delivery systems but provides no new experimental results.

This article reviews the role of epidermal proteins and their complex gene families in maintaining skin integrity and highlights insights gained from genetic studies and mouse models, without providing new clinical results.

Balanced protease activity is crucial for healthy skin and hair development.

This study reports the first keratin gene mutation affecting the tail domain, leading to a unique cytoskeletal abnormality and severe epidermal hyperkeratosis, highlighting the tail domain's critical role in keratin organization.

In this study, minoxidil did not demonstrate any anti-aging effects on postconfluent hair follicle cells, as no difference was observed in cell proliferation or differentiation compared to controls.

This study found that inhibiting AP1 transcription factor activity in the suprabasal epidermis of mice alters keratinocyte gene expression, reducing barrier integrity and mimicking human keratoderma.

This study examined variations in epidermal thickness and protein expression across different dog breeds, finding significant differences by anatomical site and breed, with associated mRNA and protein expression changes observed.

This study suggests that vitamin D-upregulated protein 1 (VDUP1) might play a unique role in regulating the differentiation of epidermal cells.

In this study, it was observed that NIPAL4 mutations linked to autosomal recessive congenital ichthyosis lead to abnormal skin barrier function due to cytotoxic effects disrupting lipid structure and organization, which topical treatments only partially ameliorated.

This study found that in mice, deleting the keratin 10 gene enhances sebocyte differentiation and increases secretion of sebum and certain lipids without affecting proliferation-associated keratins.

This review discusses the role of TGM3 in skin and hair follicle biology, human tumor pathology, and genetic abnormalities, and reports no novel results; the authors highlight its potential as a cancer diagnostic biomarker.

This study found that involucrin likely plays a key role in forming the cornified material of the medulla and inner root sheath of human hair, contributing to its mechanical strength.

2011 dermatological research found new skin aging markers, hair loss causes, skin defense mechanisms, and potential for new treatments.

Pax9 is crucial for proper tongue surface development and preventing skin-like changes.

In this study, researchers found that TCDD exposure accelerated differentiation and altered gene expression in human epidermal cells, indicating the epidermal barrier as a target of TCDD-activated AHR.

This study found that newborn mouse skin organoids can robustly grow hair in vivo, while adult organoids require specific interventions to restore their hair-forming ability.