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The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Targeted cancer therapies often cause serious skin problems that need careful management.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Silver can help prevent and treat infections but its effectiveness varies and should be weighed against costs and side effects.

Stem cell self-renewal is complex and needs more research for full understanding.

Generalized pustular psoriasis patients often need strong medication and careful treatment due to flare-ups and complications.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

K6hf is a unique protein found only in a specific layer of hair follicles.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

Giving a special protein to dogs with a certain genetic disease improved their symptoms but didn't help with hair growth.

Skin-derived precursors in hair follicles come from different origins but function similarly.

Survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis need ongoing care for various long-term health problems.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Laminin-511 is crucial for early hair growth and maintaining important hair development signals.

Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.