Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that local refinement of hair follicles into higher order patterns can occur without the core planar cell polarity system, but global alignment with body axes requires its function throughout development and regeneration.

This study found that disrupting the inturned gene in developing mouse epidermis halted hair follicle formation due to impaired keratinocyte differentiation, highlighting primary cilia's role in tissue-specific planar cell polarity signaling.

In this study, researchers explored how hair follicle orientation is affected in the rosette fancy mouse and found that a mutation in the PCP gene Fzd6 caused reversed hair orientations in the posterior region, leading to the formation of unique whorls.

The Celsr1 gene is crucial for normal hair patterning in mice.

This study found that Frizzled genes Fzd3 and Fzd6 are redundantly involved in controlling hair follicle polarity in mice, but operate through distinct mechanisms, highlighting their complex role in hair orientation.

This study found that Celsr1, not Celsr2, is the primary protein involved in establishing planar cell polarity and hair follicle polarization in the epidermis of mice.

Genetic defects in the Wnt/PCP pathway may cause congenital yellow nail syndrome.

This study demonstrated that Wnt5a can serve as an orienting signal for mouse skin's planar cell polarity but its overexpression disrupts hair follicle orientation, which can be rescued by modifying Fzd6 levels.

This study found that disruptions in planar cell polarity signaling are implicated in congenital heart defects and cardiomyopathy in developing mouse hearts, associated with early cardiomyocyte disorganization and improper heart looping.

This article reviews the role of polarity proteins in epidermal morphogenesis and homeostasis and discusses how their alteration may contribute to skin disease, but reports no new experimental findings.

This study reported that exogenous R-spondin-1 can restore hair follicle neogenesis in adult mouse cells, highlighting differences in gene expression and signaling pathways between fetal and adult dermal papilla cells.

This research reports that the polyG fragment within the Hoxc13 protein alters its gene regulatory functions, which could have influenced mammalian hair evolution by affecting pathways related to hair follicle development.

This review article summarizes recent strategies to enhance the precise control of CRISPR/Cas9 gene editing, addressing tissue-specific challenges and off-target effects by exploring various activation methods like cell-specific promoters and small molecules.

This study observed that dietary intake of glucoraphanin during juvenile and adolescent stages prevented cognitive deficits and abnormal gene expressions in the brain of adult offspring exposed to maternal immune activation, potentially implicating centrosome-related genes in the development of psychosis.

This review covers various aspects of hair biology, pigmentation, and development, focusing on genetic and biochemical modulation of hair follicle components but reports no new findings.

This study found that beta-caryophyllene enhanced re-epithelialization in cutaneous wounds of female mice, suggesting its potential for improving wound healing through multiple pathways.

In this study, beta-caryophyllene enhanced wound healing in female mice by improving re-epithelialization, cell proliferation, and cell migration, suggesting potential benefits of essential oil compounds in inflammation reduction.

In this study, researchers performed a genome-wide characterization of the Wnt gene family in domestic donkeys, identifying 19 genes and highlighting their evolutionary conservation among mammals, along with tissue-specific expression patterns potentially linked to reproductive regulation and tissue homeostasis.

This study found that strigolactone biosynthesis and signaling components in soybean may interact with other hormone pathways, influencing soybean development and nodulation.

The researchers observed that in cichlid fishes with different dental structures, tooth replacement accelerated more than three times following tooth extraction, alongside distinct changes in gene expression and cellular interactions over one week, providing insights into tooth regeneration mechanisms in vertebrates.

This study found that overexpressing the PCaP2 protein in Arabidopsis enhanced drought tolerance by influencing ABA and SA signaling pathways and regulating root hair growth, suggesting a key role in water deficit response.

This study found that Wnt5a regulates hair follicle differentiation in mice by mediating epithelial-mesenchymal interactions and influencing dermal papilla cell activities.

This study found that Merkel cell clusters require Frizzled6 signaling for their polarity information, while other hair follicle-associated structures align their orientation based on the hair follicle itself.

In this study, Far2-/- mice were observed to develop focal alopecia with altered sebaceous gland morphology and lower skin lipid levels compared to wildtype mice.

This review discusses the role of astrotactins in development and their genetic mutations' links to a variety of human diseases, but reports no new clinical results.

This review discusses the roles and mechanisms of Wnt signaling in embryonic and adult stem cells and its association with cancers, and reports no new experimental findings.

This study found that mice lacking CD61 had significantly shorter lower incisors compared to wild-type mice, suggesting CD61 is crucial for proper tooth growth and pre-ameloblast proliferation.

This review discusses the WNT signaling pathway's involvement in human diseases and highlights recent advances in WNT-related treatments, but it presents no new research findings.

This review investigates molecular mechanisms behind PCOS pathogenesis and discusses potential therapies, but reports no new clinical results.

This study reports differential gene expression in the leading edge and inner surface epithelial cells of murine eyelids, suggesting that distinct signaling pathways are active during embryonic eyelid closure.