49 citations
,
July 2021 in “Nutrients” This review explores lifestyle modifications for women with polycystic ovary syndrome, discussing dietary, physical, and supplementation strategies, but reports no new clinical results.
49 citations
,
April 2000 in “Journal of The American Academy of Dermatology” This article discusses the etiology, clinical features, diagnosis, histopathology, and treatment of alopecia areata but reports no new clinical findings; it emphasizes the palliative nature of current treatments.
48 citations
,
February 2017 in “Journal of Cosmetic Dermatology” This proposal reviews current knowledge and suggests actions for managing chemotherapy‐induced alopecia but reports no new clinical results, highlighting the need for evidence‐based guidelines.
42 citations
,
January 2019 in “Frontiers in Immunology” This study identified diltiazem, a calcium channel blocker for hypertension, as a promising repurposed treatment for influenza, enhancing antiviral efficacy when combined with oseltamivir.
42 citations
,
March 2014 in “European Journal of Pharmacology” This study found that minor ginseng saponin F2 may promote hair growth more effectively than finasteride by enhancing anagen induction and modulating the Wnt signaling pathway in cell and mouse models.
35 citations
,
May 2020 in “Frontiers in Pharmacology” This review provides a comprehensive overview of the mechanisms, efficacy, and adverse reactions of drugs commonly used for treating benign prostatic hyperplasia but reports no new clinical results.
35 citations
,
January 2011 in “Clinical Endocrinology” Metformin should be used for PCOS mainly in those with glucose intolerance, and has limited benefits for infertility or hirsutism.
35 citations
,
October 2004 in “Biology of Reproduction” This study found that dual 5α-reductase inhibition in rats led to decreased sperm motility and altered morphology, resulting in subfertility.
34 citations
,
January 2018 in “International Journal of Dermatology” This review discusses chemotherapy-induced alopecia, highlighting its pathogenesis, clinical patterns, and current therapeutic approaches, with no new clinical results reported.
32 citations
,
May 2013 in “The Journal of Urology” This study found no statistically significant association between the use of 5α-reductase inhibitors and male breast cancer incidence.
30 citations
,
June 2024 in “Scientific Reports” This study explored a keratin, sodium alginate, and carboxymethyl chitosan hydrogel modified with tannic acid and found it to have promising wound-healing qualities, including similar elasticity to human skin, antimicrobial and antioxidant properties, and effective water retention. These attributes suggest potential applications in biomedical engineering.
30 citations
,
September 2016 in “BMJ” This study found that 5-α reductase inhibitors do not significantly increase the risk of erectile dysfunction in men with benign prostatic hyperplasia or alopecia, although duration of benign prostatic hyperplasia may elevate risk.
27 citations
,
December 2015 in “Mayo Clinic Proceedings” This review presents an evidence-based algorithm for managing hidradenitis suppurativa in primary care, highlighting the need for more research on treatment effectiveness and the disease's pathogenesis.
27 citations
,
June 2015 in “Revista Brasileira de Farmacognosia” This review discusses the traditional uses, pharmacology, clinical applications, and toxicology of Carthami flos but reports no new clinical results, aiming to inform further research on its medicinal potential.
25 citations
,
March 2000 in “Journal of Endocrinological Investigation” Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.
22 citations
,
August 2015 in “Cochrane Database of Systematic Reviews” The study aims to find the best treatment for central serous chorioretinopathy by comparing various options.
22 citations
,
April 2015 in “Current problems in dermatology” Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.
22 citations
,
March 2000 in “Clinical endocrinology” This study found that while ethinyl oestradiol and cyproterone acetate effectively treated hirsutism in 90% of patients, 80% experienced relapse within six months after stopping treatment, suggesting long-term use is necessary.
19 citations
,
May 2013 in “Annals of Oncology” This study observed that aromatase inhibitors caused hair loss in menopausal women with breast cancer, mimicking male pattern baldness rather than female androgenetic alopecia.
18 citations
,
December 2014 in “Obstetrics and Gynecology Clinics of North America” This study suggests that weight loss can improve fertility outcomes in overweight and obese women with PCOS, and letrozole should be considered the new first-line treatment over clomiphene citrate for anovulatory infertility in this population.
17 citations
,
May 2003 in “Journal of The American Academy of Dermatology” This study found that miniaturized hair follicles from pattern alopecia can regenerate rapidly when transplanted onto mice and may grow as well as or better than terminal hairs.
14 citations
,
October 2019 in “International Journal of Women's Health” This article discusses the clinical presentation and management challenges of menopausal acne, noting its multifactorial etiology and recommending tailored treatment approaches based on acne severity and associated features, without reporting new clinical results.
14 citations
,
December 2010 in “Seminars in Oncology” This review discusses the diagnostic challenges of androgen and estrogen-secreting adrenal tumors and highlights that the presence of metastases is the most reliable indicator of malignancy; it reports no new clinical findings.
12 citations
,
January 2022 in “Journal of Menopausal Medicine” This review discusses the impact of COVID-19 on hormone therapy in gynecology, emphasizing the need for more high-quality evidence for individualized management, but it reports no new clinical results.
12 citations
,
January 2012 in “Current Dermatology Reports” This review discusses recent trends in non-surgical cosmetic dermatology procedures in the United States and reports no new clinical results, emphasizing the need for evidence-based evaluations of safety and efficacy.
11 citations
,
October 2016 in “Biomedicine & Pharmacotherapy” In this study, minoxidil and human platelet lysate affected gene expression related to hair growth signaling pathways in mouse hair follicle cells.
11 citations
,
March 2016 in “Translational Andrology and Urology” This review highlights the potential therapeutic applications of nandrolone, an anabolic steroid, for male health, but notes that more human studies are needed due to limited existing literature.
10 citations
,
November 2000 in “Aesthetic Surgery Journal” Secondary aesthetic surgeries for gender reassignment are generally satisfying and advance overall aesthetic surgery techniques, but psychological support is important.
10 citations
,
January 1994 in “Advances in pharmacology” This review examines the role of topoisomerase-interacting drugs in cancer treatment and emphasizes the importance of understanding their mechanisms for clinical development, but it presents no new results.
8 citations
,
November 2020 in “Nature Communications” This study demonstrates that Tp63-expressing epithelial stem cells from non-skin tissues can respond to skin morphogenetic signals and contribute to the formation of hair follicles, sebaceous glands, and epidermis.