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This review highlights how integrating medicinal chemistry with delivery science could transform the limitations of PROTACs—such as poor solubility and low cell permeability—into strengths, potentially advancing these compounds from experimental stages to clinical applications by optimizing their delivery and enhancing therapeutic efficacy.

This study reported that an ATRA-loaded nanostructured lipid carrier gel (ATRA-NLC-Gel) improved symptoms of alopecia areata in mice by enhancing transdermal drug delivery, reducing skin irritation, and promoting hair regrowth through targeted follicle enrichment and pathway activation.

This study found that nano-sized minoxidil formulations significantly increased skin penetration and follicular drug delivery for alopecia areata treatment, compared to conventional ethanol-based solutions, and demonstrated effective controlled release over six hours.

This narrative review highlights the critical role of intracrine hormone production in peripheral tissues, suggesting that continuous-release subcutaneous testosterone pellet therapy may offer a more effective symptom-driven approach for aging populations, though large-scale randomized controlled trials are needed for confirmation.

Two L-PRP treatments improve hair density in mild to moderate alopecia.

In this study, researchers used a new method with platelet-rich plasma-loaded microcarriers to enhance dermal papilla cell activity and hair follicle regeneration, achieving significant hair and vessel growth in a mouse model compared to control groups.

In this study, researchers developed an in-situ gel formulation of antibacterial Levofloxacin for the eye, which showed prolonged drug release, increased residence time, and effective antibacterial action, suggesting it may be a safe and effective ocular delivery system for antibiotics.

In this study, it was observed that topical application of N,N-Dimethylglycine Sodium Salt significantly increased skin microcirculation and blood flow in human subjects, suggesting potential benefits for skin health and conditions like dermatitis.

This study developed a new finasteride release system using chitosan-based nanoniosomes, observing that 70% of the drug was released over ten days in vitro, suggesting potential for prostate cancer prevention.

This study found that a melatonin-loaded microemulsion exhibited controlled release and significant stratum corneum deposition in ex vivo permeation tests, suggesting its potential for further evaluation in treating androgenic alopecia.

This study found that a minoxidil foamable emu oil emulsion significantly promoted hair growth in animals compared to a marketed 5% minoxidil solution, showing increased hair follicles in the anagenic phase.

This review highlights the transformative potential of bioinspired polymers in biomedical engineering, focusing on their roles in enhancing tissue engineering, regenerative medicine, and other biomedical applications, with innovations including mimicking the extracellular matrix, self-healing, antibacterial properties, and cancer therapy.

This study evaluated Finasteride-loaded nanostructured lipid carriers for topical use in treating androgenetic alopecia and found that these carriers offer sustained drug release and may reduce systemic side effects compared to oral administration.

This article reviews possible pathogenesis scenarios for hidradenitis suppurativa and emphasizes the need for focused research on the innate immune system of hair follicles to better understand the disease.

This review discusses the applications of biopolymeric composites in controlled drug release, tissue engineering, and wound healing, but reports no new experimental results, highlighting the need for further development and analysis.

This review discusses recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery, highlighting their design rationales and potential biomedical applications, but reports no new experimental results.

This study found that newly developed nanogels for transdermal delivery of finasteride were stable, showed excellent drug permeation through the skin, and ensured biocompatibility without causing irritation or toxicity.

This critique of a 2019 study highlights the potential of a liposomal hydrogel for delivering Minoxidil and Tretinoin to treat androgenetic alopecia, but underscores the need for in vivo trials and further stability and interaction analysis to validate its promise.

In this review, researchers discussed recent advances in nanotechnology for topical skin applications, highlighting how nanocarriers enhance skin penetration and targeting in treatments for diseases like melanoma and psoriasis, while acknowledging that the penetration mechanisms and health impacts of nanoparticles remain not fully understood.

This study found that capped mesoporous silica nanoparticles conjugated with antibodies selectively released a dye when exposed to finasteride, with low detection limits and stable performance even after storage.

This review indicates that while microneedling shows potential for managing androgenetic alopecia, particularly in combination with other treatments, the existing evidence is of low to moderate quality, and more robust trials are needed to confirm its clinical efficacy and safety.

This study formulated and characterized a dutasteride-loaded nanocrystalline suspension for long-acting parenteral delivery, finding that it provided sustained drug release in rats with a significant reduction in local inflammation over 28 days following intramuscular injection.

This review discusses the significance of IL-1 family cytokines in skin inflammation and pathology, emphasizing their interactions with microbes and potential therapeutic applications, but reports no new clinical results.

This study used bibliometric analysis to evaluate global research on AI applications in dermatology, identifying 406 relevant papers and highlighting current priorities such as machine learning for wound progression, AI in teledermatology, and applications for skin diseases.

The researchers developed a new follicular unit extraction system with adjustable needle lengths and precise rotation speed, which they report as being superior to existing systems for non-incisional hair transplants.

This study found that a nanoparticle-in-nanofiber system significantly accelerated wound healing in rats by promoting angiogenesis and tissue regeneration more effectively than a commercial wound dressing.

This study found that the binding and release of BMP-2 from kerateine biomaterials are significantly influenced by pH and salt concentration, highlighting the potential for developing improved bone repair systems.

In this review, recent advances in long-acting microneedle-based transdermal drug delivery systems are outlined, highlighting biodegradable polymers like PLA, PLGA, and PCL for sustained release and discussing challenges in clinical translation such as consistency in manufacturing and validating long-term efficacy and safety.

This review discusses various patent articles on microemulsion carriers in drug delivery systems and reports no new empirical findings.

In this study, researchers developed a neem oil-based emulgel showcasing anti-dandruff properties with controlled dual release, observing formulation F5 providing a 65.27% release after 8 hours and the highest antifungal inhibition against Candida albicans.