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      Bioengineering Skin Using Mechanisms of Regeneration and Repair

      research Bioengineering skin using mechanisms of regeneration and repair

      202 citations , August 2007 in “Biomaterials”
      This review discusses advancements in artificial skin for wound treatment and reports no new clinical findings; the authors highlight the potential of new biomaterials to enhance future skin replacement therapies.
      Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion

      research Keratin 17 modulates hair follicle cycling in a TN-dependent fashion

      169 citations , May 2006 in “Genes & Development”
      This study found that keratin 17 and TNFα play interdependent roles in regulating hair follicle cycling, with TNFα required for the anagen–catagen transition and its ablation partially rescuing hair cycling defects in K17-null mice.
      Hair Follicle Stem Cells: Walking the Maze

      research Hair follicle stem cells: Walking the maze

      165 citations , June 2007 in “European Journal of Cell Biology”
      This review discusses the various stem cell populations associated with hair follicles and their potential in regenerative medicine, highlighting differences between murine and human hair follicles but reports no new clinical results.
      A Perspective on RNAi-Based Biopesticides

      research A Perspective on RNAi-Based Biopesticides

      140 citations , February 2020 in “Frontiers in Plant Science”
      This article discusses the potential of RNA-based biopesticides for sustainable agriculture and reports no new experimental results; it highlights the need for improved delivery systems and regulatory development to enhance deployment.
      Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

      research Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

      130 citations , January 1994 in “Differentiation”
      In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.
      Hormesis And Medicine: Biphasic Dose-Response Relationship

      research Hormesis and medicine

      127 citations , June 2008 in “British Journal of Clinical Pharmacology”
      This study supports the conclusion that the hormetic dose-response model is the most prevalent and fundamental model in biological and biomedical sciences, applicable to a wide range of clinical conditions.
      Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia

      research Keratin 17 null mice exhibit age- and strain-dependent alopecia

      122 citations , June 2002 in “Genes & Development”
      This study found that K17 is crucial for the structural integrity and survival of hair-producing cells, with K17 null mice developing alopecia due to hair fragility and follicular alterations.
      Genetic Basis of Skin Appendage Development

      research Genetic basis of skin appendage development

      111 citations , January 2007 in “Seminars in cell & developmental biology”
      This article reviews the similarities in early development processes of hair follicles, teeth, and mammary glands and reports no new experimental findings.
      Development and Homeostasis of the Sebaceous Gland

      research Development and homeostasis of the sebaceous gland

      107 citations , August 2012 in “Seminars in Cell & Developmental Biology”
      This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.
      Skin Biopsy

      research Skin biopsy

      106 citations , December 2015 in “Journal of The American Academy of Dermatology”
      This article reviews common pitfalls in biopsy site selection and technique that can lead to misdiagnosis of various skin conditions, highlighting the importance of proper biopsy practices for improving diagnostic accuracy.
      Congenital Adrenal Hyperplasia: Comprehensive Overview and Clinical Management

      research Congenital Adrenal Hyperplasia

      100 citations , May 2011 in “Journal of Pediatric and Adolescent Gynecology”
      This review covers the pathophysiology, diagnosis, and treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency and reports no new findings.
      Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin

      research Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin

      96 citations , July 2014 in “Cold Spring Harbor Perspectives in Medicine”
      This review discusses various stem cell compartments in adult murine and human epidermis, examining their expressed markers and characterization assays, and reports no new experimental results.
      Sensitive Skin

      research Sensitive skin

      94 citations , January 2016 in “Journal of the European Academy of Dermatology and Venereology”
      Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.
      Dermal White Adipose Tissue: A New Component of the Thermogenic Response

      research Dermal white adipose tissue: a new component of the thermogenic response

      92 citations , September 2015 in “Journal of Lipid Research”
      This review discusses the roles of dermal white adipose tissue (dWAT) as an insulator, antibiotic, and regenerative tissue, highlighting its importance in systemic metabolism and immune function, but reports no new clinical results.
      Trichoscopy of Alopecia Areata: An Update

      research Trichoscopy of alopecia areata: An update

      89 citations , March 2018 in “The Journal of Dermatology”
      This review presents various trichoscopic findings for diagnosing alopecia areata but reports no new clinical results, emphasizing that no single marker is pathognomonic and multiple features should be considered together.
      BMP2 And BMP7 Play Antagonistic Roles In Feather Induction

      research BMP2 and BMP7 play antagonistic roles in feather induction

      88 citations , July 2008 in “Development”
      This study shows that BMP2 and BMP7 play complex, necessary roles in feather development by regulating dermal condensation formation, with BMP7 acting early as a chemoattractant and BMP2 halting cell migration.
      The Blastema and Epimorphic Regeneration in Mammals

      research The blastema and epimorphic regeneration in mammals

      85 citations , December 2017 in “Developmental Biology”
      This review discusses mammalian models of epimorphic regeneration to define a vertebrate regeneration blastema, concluding that regenerative failure likely stems from cellular responses to the microenvironment after injury, not progenitor cell availability, and calls for targeted modification studies in mammals to advance human regeneration.
      Myocardial NF-κB Activation Is Essential for Zebrafish Heart Regeneration

      research Myocardial NF-κB activation is essential for zebrafish heart regeneration

      85 citations , October 2015 in “Proceedings of the National Academy of Sciences of the United States of America”
      This study found that NF-κB signaling may connect injury response to regenerative processes in zebrafish hearts, potentially aiding the development of cardiac regenerative therapies in humans.
      Building Epithelial Tissues From Skin Stem Cells

      research Building Epithelial Tissues from Skin Stem Cells

      84 citations , January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology”
      This article reviews recent advancements in understanding skin stem cells and their roles in maintaining epidermal homeostasis and repairing wounds, without presenting new experimental findings.