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Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Trichoscopy is a useful tool for diagnosing hair disorders without pulling out hair.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

Pig blood can be used to mass-produce stable, low-cost platelet dry powder for medical use.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

Drug repurposing shows promise for treating many medical conditions.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

Skin problems in older people can indicate hormonal diseases, nutritional deficiencies, or conditions like diabetes, menopause, and HIV.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

The symposium concluded that hair growth involves complex processes, including the hair follicle life cycle, the role of the dermal papilla, hair strength, pigmentation, and the impact of diseases and treatments like minoxidil on hair and skin.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.

Good nutrition is crucial for health and preventing disease, and supplements can help prevent nutrient deficiencies.

Notch signaling disruptions can cause various skin diseases.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Pili torti is a rare condition where hair is twisted and breaks easily, often linked to genetic disorders or other health issues.

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.