August 2023 in “Scientia Pharmaceutica” In this study, researchers evaluated the stability and color changes of compounded minoxidil formulations used for alopecia, finding that while the formulations remained chemically and microbiologically stable for up to 380 days, significant color changes were observed, which likely do not affect the product's effectiveness.
1 citations
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January 2023 in “Journal of Clinical Medicine” This paper presents the first reported case of Acute Localized Exanthematous Pustulosis linked to topical minoxidil use, suggesting a contact-induced hypersensitivity reaction as a potential mechanism.
January 2025 in “Journal of Pharmacognosy and Phytochemistry” This study developed plant-pigment-based shampoos using extracts from Neem, Fenugreek, Hibiscus, and Butterfly Pea, which demonstrated stability, antimicrobial properties, and potential scalp benefits such as hair growth promotion and dandruff reduction, making them a promising alternative to synthetic dyes.
1 citations
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June 2021 in “International journal of pharmaceutical compounding” This study found that compounded minoxidil solutions in a propylene glycol-free and alcohol-reduced foam remained stable for 180 days, meeting United States Pharmacopeia standards for strength, pH, and antimicrobial effectiveness.
4 citations
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June 2013 in “PubMed” This study found that minoxidil in Espumil Foam Base remains stable for at least 90 days when stored at room temperature and protected from light.
December 2025 in “PubMed” In this study, researchers found that a propylene glycol-free and alcohol-reduced topical foam containing minoxidil and finasteride remained chemically, physically, and microbially stable for 180 days when stored properly at room temperature in light-resistant containers.
This abstract introduces TrichoFoam™, a new foaming vehicle for compounding pharmacies, designed to be a gentle, non-irritating option for alopecia treatment, acknowledging that current topical treatments are limited and oral products may cause adverse effects.
25 citations
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January 2019 in “Journal of Pharmacy And Bioallied Sciences” This study concluded that the formulated polyherbal shampoo is a chemical-free product with nourishing, conditioning, cleansing, and antimicrobial effects.
July 2020 in “International journal for research in applied science and engineering technology” This study reports that a newly formulated herbal shampoo using natural ingredients like fenugreek and shikakai was successfully developed to eliminate harmful synthetic components in anti-dandruff shampoos.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers developed and tested an herbal antidandruff shampoo using plant extracts like neem, fenugreek seed, aloe vera, and clove, demonstrating antibacterial and antifungal activity against common scalp microbes and offering a potential natural alternative for dandruff treatment.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers formulated an herbal antidandruff shampoo using plant extracts like neem, fenugreek seed, aloe vera, and clove, demonstrating its antifungal activity against Malassezia furfur and potential as a natural alternative for addressing dandruff.
3 citations
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July 2020 in “International Journal of Applied Pharmaceutics” This study evaluated shampoo formulations containing banana corm extract and found that they possess favorable physical and stability characteristics, suggesting potential as a natural haircare product.
This study concluded that a shampoo with 10% sodium lauryl sulfate showed the best physical properties among the tested formulas, aligning closely with the Indonesian National Standard.
July 2023 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” This study evaluated the resin oil of Copaifera officinalis L., identifying 64 compounds and developing validated analytical methods for quality control, and formulated a stable pharmaceutical foam, laying groundwork for potential clinical applications of copaiba oil.
March 2026 in “International Journal of Pharmaceutics and Drug Analysis” This study formulated an herbal anti-dandruff shampoo using jackfruit seed extract and evaluated its effectiveness against Malassezia furfur, finding that the fourth formulation exhibited both strong antifungal activity and stability, suggesting a natural alternative to synthetic hair care products.
May 2026 in “International Journal of Research Publication and Reviews” This study evaluated a polyherbal powder shampoo composed of natural ingredients like Neem and Amla, finding it to have good stability, cleansing ability, and no irritation, offering a safe alternative to synthetic shampoos for regular use in hair care.
March 2023 in “International journal of biology, pharmacy and allied sciences” This study developed a herbal shampoo using fermented oryza sativa water and natural ingredients like amla and aloe vera, reporting that it effectively removes sebum, filth, and dandruff while promoting hair growth and strengthening.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights the benefits and preparation of herbal shampoos using plant-based extracts, which are found to clean gently, strengthen hair, promote growth, reduce dandruff, and improve hair texture while being environmentally friendly due to their non-toxic and biodegradable properties.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights the growing popularity and benefits of herbal shampoos, which use plant-based extracts to provide a gentle, effective, and environmentally friendly alternative to conventional chemical shampoos, promoting hair health and eco-sustainability.
2 citations
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March 2015 in “Dermatologic Therapy” Using too much minoxidil foam can cause a rare movement disorder with facial twitching, but symptoms go away when the correct dose is used.
100 citations
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June 2011 in “Journal of The American Academy of Dermatology” This study found that a once-daily 5% minoxidil topical foam is as effective as a twice-daily 2% minoxidil topical solution for hair growth in women with androgenetic alopecia, with fewer side effects and greater styling convenience.
76 citations
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February 2015 in “Industrial Crops and Products” This study identified over 40 phytochemical compounds in the leaves and flowers of Bituminaria bituminosa, predominantly glycosylated flavonoids from apigenin, using advanced chromatographic techniques.
66 citations
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July 2003 in “International Journal of Dermatology” This study found that betamethasone valerate foam was more effective and well-tolerated than betamethasone dipropionate lotion in treating mild-to-moderate alopecia areata, with higher hair regrowth rates observed.
27 citations
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February 2017 in “Clinical, Cosmetic and Investigational Dermatology” In this study, a topical formulation with compounds from the monoterpenoid family significantly improved hair growth indicators like anagen:telogen ratio, hair fall, and visual hair density in men and women with pattern hair loss.
October 2025 in “Interdiciplinary Journal and Hummanity (INJURITY)” This study characterized bioactive compounds in extracts from six Kalimantan herbal plants, confirming traditional medicinal uses with findings such as triterpenoids and several potent compounds with antimicrobial and cardiovascular benefits, laying groundwork for potential therapeutic applications and conservation efforts.
January 2025 in “International Journal of Advanced Research in Science Communication and Technology” This systematic review highlights the potential of herbal shampoos, formulated with ingredients like Neem, Bhringraj, and Aloe Vera, to promote hair growth and reduce dandruff, while also discussing modern techniques and challenges in their development and evaluation.
4 citations
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January 2014 in “RSC Advances” A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.
74 citations
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June 2010 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that hair follicles are a significant and efficient pathway for the absorption of topical minoxidil foam in humans, with faster blood detection when follicles are open.
15 citations
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January 2021 in “Cellular and Molecular Biology” This study found that Prosopis farcta is a rich source of phenolic compounds with strong antioxidant activity, suggesting its potential for use in food, beverage, feed, and pharmaceutical applications.
25 citations
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January 2010 in “International Journal of Pharmaceutics” This study found that polymeric nanoparticles retained more minoxidil and facilitated superior drug permeation compared to lipid nanoparticles, although premature drug release affected formulation performance.