94 citations
,
July 1991 in “Clinical endocrinology” In this study, cyproterone acetate at 2 mg daily was found to be as effective as higher doses in reducing hair growth for hirsute women over 12 months.
74 citations
,
January 2011 in “Reproductive Biology and Endocrinology” This study suggests testosterone gel administered for one year to male chronic pain patients receiving morphine may improve sexual function and mental health, despite limited effects on overall pain scores.
71 citations
,
December 1987 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium” This review highlights the challenges of using hair mineral analyses as precise indicators of mineral status due to various influencing factors, suggesting they may be informative when combined with other indicators.
68 citations
,
May 1991 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study found that both cyproterone acetate and spironolactone effectively reduced hair diameter and plasma testosterone levels in hirsute women, with no significant differences between the two treatments.
57 citations
,
August 2018 in “British Journal of Dermatology” This review discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy and reports no new clinical results, emphasizing the need for tailored guidelines.
54 citations
,
June 2018 in “Journal of the American Academy of Child and Adolescent Psychiatry” This narrative review presents composite cases of individuals undergoing gender-affirming care, illustrating varied outcomes without reporting new clinical results or systematic findings.
51 citations
,
October 2024 in “Pharmaceutics” This review highlights the potential of permeation enhancers to improve the delivery of active ingredients across the skin, optimizing therapeutic outcomes despite challenges posed by individual variability and environmental factors, according to the authors' analysis of current understanding and applications in skincare and transdermal therapies.
51 citations
,
March 2018 in “Journal of Investigative Dermatology” This study highlights the need for standardized preclinical murine models to improve the translation of wound healing research to human clinical applications, specifically noting variations in diabetes duration, animal sex, and assessment methods on healing outcomes in rat models.
50 citations
,
May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses the role of estrogens in hair follicle cycling and the skin, highlighting the need for more research on estrogen signaling pathways and their interactions with other factors in hair biology.
48 citations
,
May 2012 in “Journal of cosmetic and laser therapy” This study found that fractional bipolar RF energy significantly reduced acne scar severity and improved skin texture, with high subject satisfaction and limited side effects.
45 citations
,
December 2007 in “The FASEB journal” This study demonstrated that hair follicle bulge stem cells can form epidermis in a tissue-engineered skin model, highlighting the significance of K5/K17 filaments in slow-cycling stem cell subsets.
44 citations
,
October 2020 in “Arthritis Care & Research” This review summarizes various indices used to assess disease activity and damage in systemic lupus erythematosus, highlighting challenges in universal consensus and their practical applications in research and clinical settings.
44 citations
,
April 2012 in “American Journal of Clinical Dermatology” Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.
43 citations
,
July 2019 in “Stem Cells International” This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.
42 citations
,
November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This review discusses recent advancements in hair cosmetic agents, including topical growth stimulants and anti-aging compounds, emphasizing molecular technology's role in understanding hair growth and aging; it does not report new results.
40 citations
,
April 2008 in “European journal of endocrinology” In this study, treatment with insulin sensitizers significantly increased adipose tissue GLUT4 mRNA expression and improved insulin resistance, menstrual patterns, and androgen profiles in PCOS patients, with rosiglitazone being more effective than metformin.
38 citations
,
December 2020 in “Cancers” This review discusses current clinical trials targeting Wnt signaling in gastrointestinal cancers and reports no new results; the authors highlight challenges and consider alternative strategies for cancer treatment.
31 citations
,
January 2021 in “Experimental Dermatology” This review discusses recent advancements in generating appendage-bearing skin organoids from pluripotent stem cells and their potential applications in dermatological research, but reports no new clinical results.
28 citations
,
August 2020 in “F1000Research” This review discusses the multifactorial pathogenesis of hidradenitis suppurativa and calls for more diverse, standardized clinical trials to improve treatment and understanding of dietary influences, reporting no new results.
28 citations
,
November 2014 in “Current Diabetes Reports” This review discusses the complex links between polycystic ovary syndrome, insulin resistance, and potential metabolic risks starting in adolescence, noting the need for early screening and treatment but reports no new clinical results.
26 citations
,
January 2007 in “Organogenesis” This review outlines the evolution of hair follicle engineering and its foundational discoveries, but reports no new experimental results.
26 citations
,
March 1994 in “Archives of Dermatology” This study found that a 2% topical minoxidil solution was significantly more effective than a placebo in promoting hair growth in women with androgenetic alopecia over 32 weeks.
25 citations
,
March 2017 in “Experimental Dermatology” This review discusses various aspects of hair follicle biology and highlights unresolved questions and potential new research avenues, but presents no new experimental findings.
25 citations
,
October 1984 in “Journal of Clinical Investigation” This study demonstrated that human sebaceous glands can be successfully transplanted onto nude mice, where androgen stimulation increases gland volume, cell size, and labeling index.
22 citations
,
September 1982 in “Journal of ultrastructure research” This study reports new cellular features and complex interaction systems in fiber differentiation, indicating more intricate cellular organization than previously recognized, including features like mast cells and primary cilia.
20 citations
,
February 2023 in “Biology” This review highlights the possibility of safely altering hair color through innovative cosmetics by targeting key biological processes in hair follicles, using insights from mammalian pigmentation studies and drug-induced hair color changes as potential pathways.
20 citations
,
March 2015 in “Archives of Plastic Surgery” This article discusses the unique challenges of performing facelifts on Asian patients due to their thicker and larger skin, and it reports no procedural outcomes.
20 citations
,
January 2010 This article discusses advances in hair restoration surgery techniques but reports no new findings, noting potential challenges for new surgeons who face increased demands in time and labor.
19 citations
,
October 2007 in “Wound Repair and Regeneration” This paper reviews signaling influences and niches of epidermal stem cells and compares various types, but does not present new experimental findings.
19 citations
,
October 1996 in “Dermatologic Clinics” This review discusses using cultured dermal papilla cells to investigate hair follicle biology, emphasizing their potential to inform treatments, but reports no new clinical results.