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In this review, the authors explored the diverse roles of fibroblasts in wound healing, suggesting that understanding their complexity could lead to better insights into wound pathologies and the development of new treatments.

In this study, the isotopic fractionation between tissues and diets of captive Japanese macaques was quantified, particularly noting hair's response to diet changes in controlled conditions, but these findings underscore the complexity of reconstructing long-term dietary history.

This review discusses 3D bioprinting methods for urological diseases, noting its potential to create functional organs for transplantation despite challenges in replicating organ complexity and material limitations.

Understanding skin, hair, and nails is crucial due to their complexity and impact on health.

In this study, researchers used 3D bioprinting to successfully create engineered skin tissues with hair follicle-like structures, potentially enhancing skin grafts and safety testing for chemical compounds by more closely mimicking natural skin complexity.

This study describes a protocol for generating hair-bearing skin organoids from human pluripotent stem cells, achieving full complexity resembling fetal skin tissue by day 130 in vitro.

This study found that while genetic variants contribute minimally to predicting hair greying in a Polish population, age remains the primary predictor, underscoring the complexity of hair greying as a genetic trait.

This review discusses current concepts on the role of retinoids in keratinization and does not report new clinical results; the authors emphasize the complexity of retinoid effects on skin.

In this study, researchers reviewed the progress and challenges in using hydrogels for 3D printing in biomedical applications, highlighting advancements in structural complexity, and identifying ongoing issues like resolution improvement, cell viability, and ethical concerns for clinical use.

This review discusses challenges in managing cutaneous drug reactions to anticonvulsants and reports no new clinical findings; the authors emphasize the complexity of discontinuing or rechallenging suspected agents.

This review summarizes that polyesters hold promise for vascular tissue engineering due to their mechanical properties and biodegradability, but optimizing their use in repairing damaged blood vessels remains challenging due to the complexity of vascular tissues.

This review of 1360 scalp biopsy specimens revealed that 12.5% of cases involved multifactorial alopecia, highlighting the diagnostic complexity of multiple forms of alopecia present in single biopsies.

This study found that serum testosterone levels significantly increased during major head and neck surgeries in maxillofacial surgeons, influenced by factors like tumor size and procedural complexity.

This article discusses the follicular-unit grafting technique for hair transplantation and reports no clinical results; the authors highlight its potential for achieving natural-appearing outcomes but note the procedure's complexity.

This thesis explores the synthesis and antiproliferative properties of phenylpropanoid sucrose esters, noting the absence of synthetic methods for most of this compound class due to their structural complexity.

This case report describes a 15-year-old girl with severe hyperandrogenaemia linked to both an ovarian androgen-secreting tumor and HAIR-AN syndrome, highlighting the complexity of diagnosing polycystic ovarian syndrome.

This review discusses various causes of hair loss, emphasizing androgenetic alopecia, and reports no new findings; the author highlights the complexity of hair transplantation consultations.

This case report discusses a 56-year-old female patient with multiple risk factors, including diabetes mellitus and liver cirrhosis, who developed necrotizing fasciitis, emphasizing the complexity and high cost of treatment required.

This study found that while dutasteride significantly altered pregnane metabolism in mares during late gestation, it did not impact pregnancy outcomes, highlighting the complexity of pregnane metabolism and the necessity of LC-MS/MS for accurate measurement.

This narrative review reflects on the challenges faced by FDA's Oncologic Drugs Advisory Committee members, highlighting public pressure, decision-making complexity, and the evolving landscape of cancer drug development.

This review examines androgenetic alopecia, detailing its causes and current treatments, but reports no new clinical results; the authors emphasize understanding its complexity for personalized therapy development.

This study described the population-level incidence of erectile dysfunction in men using finasteride for androgenetic alopecia, finding a varied risk that highlights the complexity of interpreting sexual side effects.

In this case study, a 38-year-old woman with monilethrix, a hair shaft disorder causing hair fragility, was also diagnosed with androgenetic alopecia, leading the authors to emphasize the complexity in diagnosing and managing such combined hair conditions.

This study highlights how combining genetic and environmental risk assessments could advance early screening and personalized prevention for vitiligo, given its genetic complexity and environmental interactions.

This collection of research papers details a range of health topics, including iodine's essential role across biological kingdoms, holistic health factors, advances in pediatric practice, the complexity of sinus septa in medical procedures, and innovative delivery methods for treating hair loss with nanostructured lipid carriers.

This study by Moore et al. (2025) provides the first evidence linking C-tactile afferents in humans to hair follicles, showing that these nerve fibers respond to hair movement rather than skin deformation, adding complexity to the understanding of their role in emotion and touch.

This study found that monotherapy and topical medications are primarily used to treat pediatric skin diseases, with a variety of drugs prescribed indicating the complexity of these conditions.

This literature review found that among therapies for Alopecia Areata, Janus kinase inhibitors are particularly promising despite safety challenges, while newer approaches like stem cells face cost and complexity issues; a comprehensive approach integrating medical and emotional support was emphasized for improving patient outcomes.

In this case report, a rare association between Cushing's syndrome caused by ectopic ACTH from cervical cancer is documented, highlighting the diagnostic challenges, treatment complexity, and high morbidity and mortality, with the patient succumbing to septic shock post-surgery.

This study highlights a rare case of vitamin D-dependent rickets type 2A caused by a heterozygous mutation in the vitamin D receptor gene, emphasizing the complexity of managing this condition with high-dose calcium and vitamin D therapy.