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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

PSA could be a marker for hyperandrogenism in women, but more research is needed.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Anti-androgens can help manage some PCOS symptoms better than metformin but are not more effective than placebos or birth control pills for other symptoms.

Cocaine impairs male sexual behavior and alters testosterone metabolism in the brain.

Excessive hair growth can be assessed by history, exam, and blood tests, and treated with medication like dexamethasone, birth control pills, and spironolactone.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Potassium channel openers like minoxidil help hair grow by acting on hair follicles.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.

Ultrasound measurement of the ovarian stroma to total area ratio is not a reliable single predictor of high male hormone levels in Thai women with PCOS, but works better when combined with clinical signs.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

A systematic approach is crucial for managing hair loss in women.

Higher fluoride levels may delay puberty in boys.

Annurca apple supplement safely increases hair growth and keratin in humans.

Different levels of anti-Müllerian hormone can help diagnose polycystic ovary syndrome in women of different ages.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Researchers created a mouse model of a type of rickets that does not cause hair loss.

Platelet-rich plasma therapy helps increase hair density in male patients with hair loss but doesn't change hair thickness.

Many young Italian women have hyperandrogenic disorders like PCOS, which are linked to age, body weight, and insulin resistance.

Spironolactone does not increase cancer risk and may lower prostate cancer risk, but more research is needed.

A woman with PCOS successfully overcame secondary infertility and became pregnant with triplets after treatment.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

Eating less starch and dairy helped overweight women with PCOS lose weight and improve symptoms.

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

Ashwagandha root improved symptoms of nonclassic 11-hydroxylase deficiency in an elderly woman.

Women with PCOS are much more likely to experience depression.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.