June 2024 in “Research Square (Research Square)” This study found that among patients with systemic lupus erythematosus, the absence of skin rash and low levels of complement C3 were significant risk factors for developing lupus nephritis, with their combination demonstrating good predictive diagnostic value.
2 citations
,
March 2023 in “3C Empresa Investigación y pensamiento crítico” In this study, patients with alopecia areata showed significantly elevated serum levels of IFN-γ and severely deficient vitamin D3 levels compared to healthy controls.
39 citations
,
September 2017 in “The Open Rheumatology Journal” This review discusses the role of complement activation in SLE and suggests that while monitoring C3 and C4 remains important, increased levels of cell-bound complement activation products may better indicate disease activity.
1 citations
,
January 2015 in “Advanced techniques in biology & medicine” This study found that among patients with Down syndrome, those with alopecia areata may have increased antiperoxidase antibodies, possibly linked to hypothyroidism.
1 citations
,
July 2012 in “Nasza Dermatologia Online” This case report suggests that immune responses, along with hair traction, may play a role in the etiology of central centrifugal cicatricial alopecia.
August 2021 in “BMJ Case Reports” This case report details a 27-year-old woman's diagnosis of systemic lupus erythematosus with immune-mediated intravascular haemolysis, which improved with steroid treatment.
February 2018 in “Chin J Clinicians(Electronic Edition)” This study found that rash in SLE patients is prevalent and associated with more severe disease indicators, including certain clinical manifestations and serological abnormalities.
January 2005 in “Chinese Journal of Integrated Traditional and Western Nephrology” This study found that systemic lupus erythematosus in aging patients often presents with atypical clinical manifestations, leading to more frequent misdiagnosis, yet these patients may respond better to treatment.
June 2020 in “Annals of the Rheumatic Diseases” This observational study concluded that anti-Ku antibodies do not specifically indicate any systemic autoimmune disease or associated clinical phenotype.
51 citations
,
May 1984 in “Journal of the American Academy of Dermatology” In this study, the authors observed that cell-mediated immune mechanisms may be involved in the pathogenesis of benign follicular mucinosis, based on the cellular and immunological characteristics of two patient cases.
10 citations
,
August 1991 in “PubMed” This study supports the idea that inflammation may play a role in the development of androgenetic alopecia, as indicated by certain immune deposits and porphyrins found more frequently in bald scalp biopsies compared to controls.
May 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reported that specific inhibition of the classical complement pathway with BIVV009 prevented C3 deposition along the dermal-epidermal junction in bullous pemphigoid, reflecting its potential efficacy.
64 citations
,
May 2000 in “International Journal of Dermatology” This study found that thalidomide increased peripheral lymphocyte counts and reduced inflammation in lupus erythematosus patients, but was associated with polyneuropathy, suggesting careful use in refractory cases.
16 citations
,
September 2020 in “British journal of dermatology/British journal of dermatology, Supplement” This review explores the role of neutrophil recruitment in the inflammation seen in hidradenitis suppurativa and emphasizes potential therapeutic targets within these pathways, but it reports no new clinical results.
16 citations
,
May 1998 in “International Journal of Dermatology” This study found that elevated serum cortisol levels and other immunological changes are significantly involved in the active phases of psoriasis eruptions.
3 citations
,
June 2020 in “Open access rheumatology” This case report reviews the management of Rowell syndrome in a patient initially diagnosed with Rhupus syndrome and highlights their development of erythema multiforme after certain medications.
January 2025 in “Biomedical Reports” This case report describes the first successful use of telitacicept in treating a patient with systemic lupus erythematosus and a history of papillary thyroid carcinoma, suggesting its potential as a therapeutic option for such conditions.
5 citations
,
February 1977 in “Archives of Dermatology” This study reports that 14 of 19 patients with erythema nodosum leprosum had C3 deposits in vessel walls when examined using direct immunofluorescence.
5 citations
,
August 1981 in “Archives of Dermatology” This paper examines the potential autoimmune basis of alopecia areata, but reports no new clinical results; the focus is on analyzing complement levels and macrophage migration inhibition factor in patients.
June 2006 in “Annales de Dermatologie et de Vénéréologie” This review highlights the potential benefits of spironolactone in dermatology, particularly for female acne, supporting its safety over long-term use without extensive testing, but presents no new clinical results.
5 citations
,
September 2021 in “Journal of cosmetic dermatology” This study found that alopecia areata patients had significantly abnormal T3, T4, TPOAbs, ANA, and lower vitamin D levels compared to healthy controls.
3 citations
,
February 2020 in “The Egyptian Rheumatologist” This case report from Tishreen Hospital describes the rare presentation of lupus erythematosus tumidus and autoimmune thyroid dysfunction as initial manifestations of systemic lupus erythematosus, highlighting the importance of early diagnosis for better outcomes.
97 citations
,
December 2011 in “New England Journal of Medicine” This article discusses the FDA's decision not to approve 5α-reductase inhibitors for prostate cancer prevention, citing an increase in high-grade tumors but no mortality evidence, and reports no new results.
November 2025 in “The Journal of Immunology” In this study, researchers observed elevated levels of epidermal γδ T cells, keratinocytes, and an upregulation of the BST2 gene among immune cells in C3H/HeJ mice with alopecia areata, suggesting a potential role in disease pathogenesis.
May 2025 in “The Journal of Rheumatology” This case report describes a patient with systemic lupus erythematosus whose unusual nephrological presentation led to a diagnosis of C3 glomerulopathy, highlighting the importance of considering atypical findings to broaden diagnostic approaches.
6 citations
,
July 2021 in “Bulletin of the National Research Centre/Bulletin of the National Research Center” This review discusses the transmission and immune response of SARS-CoV-2 and highlights ongoing research for developing vaccines and antiviral treatments, but it presents no new clinical findings.
71 citations
,
May 2019 in “Rheumatology” This study observed that PD-1+CXCR5-CD4+T peripheral helper cells are significantly elevated in patients with systemic lupus erythematosus and are correlated with disease activity indicators, suggesting their potential role in lupus pathogenesis.
23 citations
,
August 1983 in “PubMed” This case report details a 17-year-old girl with systemic lupus erythematosus and recurrent infections linked to a complete isolated Clq deficiency.
May 2024 in “International journal of medicine and psychology.” This study found that in laboratory rats, toxic concentrations of hydrogen sulfide affected the immune system differently depending on age and immune suppression status, with notable changes in immune cell levels and phagocytosis, suggesting significant roles in age-associated pathologies.
In this case report, a 19-year-old woman with systemic lupus erythematosus experienced significant improvement in neuropsychiatric symptoms, including psychosis and seizures, following treatment with high-dose corticosteroids, immunosuppressants, and antidepressants.