research Drugs Affecting Blood Coagulation, Fibrinolysis, and Hemostasis
Some blood-thinning medications can increase the risk of bleeding, and certain factors like genetics and other health conditions affect their safety and effectiveness.
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research Alopecia: Unapproved Treatments or Indications
Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.
research Disposition and Pharmacokinetics of [14C]Finasteride After Oral Administration in Humans
research Baiting Proteins with C60
C60 fullerenes can alter protein function and may help develop new disease inhibitors.
research Rosemary Extracts Containing Carnosic Acid and Carnosol Are Potent Quorum Sensing Inhibitors of Staphylococcus Aureus Virulence
Rosemary extracts with carnosic acid and carnosol can reduce the harmfulness of Staphylococcus aureus without stopping its growth.
research Discriminating in Favor of or Against Men with Increased Risk of Finasteride-Related Side Effects?
Finasteride treats baldness but may cause lasting sexual side effects.
research A Population Pharmacokinetic Model for Individualized Regimens of Finasteride According to CYP3A5 Genotype and Liver Function
Finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid side effects.
research C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency
Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.
research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia
Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.
research 11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro
11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.
research An Asian Traditional Herbal Complex Containing Houttuynia Cordata Thunb, Perilla Frutescens Var. Acuta, and Green Tea Stimulates Hair Growth in Mice
The Asian herbal mix with Houttuynia cordata, Perilla frutescens, and green tea helped grow hair in mice.
research Enzymes
Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
research Endoplasmic Reticulum Stress Upregulates NKG2D Ligands in the Hair Follicle
Stress in hair follicle cells increases certain immune-related proteins, which might contribute to hair loss conditions.
research Evaluation of Polymorphism Influence in Finasteride
Different forms of finasteride dissolve and remain stable differently, affecting capsule quality.
research Drug Repurposing Against KRAS Mutant G12C: A Machine Learning, Molecular Docking, and Molecular Dynamics Study
Afatinib, neratinib, and zanubrutinib could be effective against KRASG12C-mutant tumors.
research Neonatal Inhibition of Androgen Activity Alters the Programming of Body Weight and Orexinergic Peptides Differentially in Male and Female Rats
Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.
research Pharmacogenetic Analysis of Human Steroid 5α Reductase Type II: Comparison of Finasteride and Dutasteride
Dutasteride is more efficient than finasteride, but individual results vary.
research Dutasteride: A Review of Its Use in the Management of Prostate Disorders
Dutasteride is effective for treating prostate enlargement and reducing related surgery risk, but is not approved for preventing prostate cancer.
research Comparative Study Between Fractional CO2 Laser Alone Versus Fractional CO2 Laser Combined With Topical Dutasteride in Treatment of Male Androgenic Alopecia
Combining fractional CO2 laser with topical dutasteride is more effective for treating male hair loss than using the laser alone.
research Trichodysplasia of Immunosuppression Treated with Oral Valganciclovir
Oral valganciclovir improved a patient's skin condition caused by immunosuppression.
research Cyproterone Acetate: A Genotoxic Carcinogen?
Cyproterone acetate may cause liver cancer at high doses, but is considered safe at recommended doses for approved uses.
research Dutasteride in Androgenetic Alopecia: An Update
Dutasteride is becoming a popular hair loss treatment, proving more effective than finasteride with similar side effects.
research Resistance Training Improves Finasteride-Induced Protein Homeostasis Disruption in Rat Skeletal Muscle
Resistance exercise helps improve muscle protein balance disrupted by finasteride.
research Bioactive Metabolites of Edible Mushrooms Efficacious Against Androgenic Alopecia: Targeting SRD5A2 Using Computational Approach
Mushroom compounds may help treat hair loss better than Finasteride.
research Oral Bicalutamide for Female Pattern Hair Loss: A Pilot Study
Bicalutamide improves hair density in women safely.
research Comparison of Cyproterone Acetate Plus Ethinyl Estradiol and Finasteride in the Treatment of Hirsutism
Cyproterone acetate plus ethinyl estradiol is generally more effective in treating hirsutism, but consider side effects and patient characteristics.
research Molecular Targeted Agents and Biologic Therapies for Non-Small Cell Lung Cancer
New treatments for non-small cell lung cancer are being tested, with some already in use, focusing on immune response and targeting cancer cells, but side effects vary.
research Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole
Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.
research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition
Finasteride effectively blocks rat enzymes, but with varying methods and strength.
research Determination of Rat 5α-Reductase Type 1 Isozyme Activity and Its Inhibition by Novel Steroidal Oxazolines
New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.