January 2025 in “ARC Journal of Clinical Case Reports” This case report suggests that using encapsulated retinol in polylysine may effectively treat actinic keratosis with minimal irritation, potentially providing a safer alternative for frequent use.
This study proposes a new treatment protocol combining autologous regenerative therapy with mesotherapy and photobiostimulation for androgenetic alopecia, leveraging adipose-derived stem cells to stimulate hair follicle regeneration.
January 2025 in “Exploratory Animal and Medical Research” Among adult male rats, this study found that combined exposure to lithium carbonate and lead acetate over 28 days led to synergistic cardiotoxic effects, evidenced by oxidative stress, ECG abnormalities, and molecular markers of increased apoptosis, despite no observable structural damage to myocardial tissue.
January 2025 in “American Journal of Translational Research” This study reported that the combination of EE-CPA and raloxifene effectively manages PCOS-related infertility, enhancing pregnancy outcomes through improvements in metabolism, sex hormones, ovarian function, and endometrial receptivity, without significantly increasing adverse effects.
January 2025 in “中医药研究与应用（Research and application of traditional Chinese medicine）” In this study involving acne patients, researchers compared the effects of combined fire needle and salicylic acid therapy with conventional treatment, measuring improvements in skin lesion severity, skin barrier function, and microbiota diversity; results are not reported in the abstract.
October 2024 in “JURNAL ILMU KEFARMASIAN INDONESIA” This study found that the F6 formulation of a hair tonic containing EDS and ATG extracts produced the most significant hair growth in rabbits, without causing skin irritation and remaining stable throughout the observation period.
This study developed a bioresponsive hydrogel combining basic fibroblast growth factor and N-acetylcysteine, which significantly improved diabetic wound healing by enhancing re-epithelialization, collagen deposition, hair follicle regeneration, and neovascularization in response to oxidative stress.
In this study, among 30 patients with androgenetic alopecia, topical Minoxidil was effective alone or in combination with either oral or microneedling-applied Dutasteride, with the microneedling approach offering promising results and fewer side effects compared to oral Dutasteride.
This study suggests that a combination of blue light photobiomodulation and biomimetic peptide infiltrations may effectively increase hair density in patients with androgenetic alopecia.
This study reported that Sintilimab combined with chemotherapy may improve outcomes in advanced NSCLC patients but carries a higher risk of certain side effects, including hypothyroidism.
May 2024 in “Aesthetic plastic surgery” This meta-analysis suggests that combining platelet-rich plasma with minoxidil enhances hair growth and patient satisfaction more effectively than using either treatment alone for androgenetic alopecia.
April 2024 in “MRIMS journal of health sciences” This study observed that autologous growth factor concentrate combined with topical minoxidil significantly improved hair growth and patient satisfaction in individuals with androgenic alopecia, with no adverse effects reported.
February 2024 in “Dermatology Reports” In this randomized controlled trial, combining 4-weekly microneedling with 5% minoxidil significantly increased hair density and diameter in men with androgenetic alopecia compared to minoxidil alone, while side effects were minor and tolerable.
January 2024 in “Future postharvest and food” This study reviewed the historical and current uses of frankincense, highlighting its potential antiviral, anti-inflammatory, and immunomodulatory effects, particularly noting some clinical evidence that suggests its use in treating COVID-19 symptoms, although more data is needed.
January 2024 in “Editora Científica Digital eBooks” This study conducted an integrative review of bioactive substances and their effectiveness in controlling hair loss and scalp disorders, evaluating their potential to restore hair cycle balance and strengthen hair strands, while identifying knowledge gaps and opportunities for future research.
January 2024 in “Journal of Biosciences and Medicines” In this study, combining Ginkgo biloba extract dropping pills with butylphthalide capsules improved cognitive and neurological function, daily living activities, and reduced inflammatory responses in patients with cognitive dysfunction following an acute ischemic stroke, compared to butylphthalide treatment alone.
November 2023 in “PubMed” This study found that treating mice with naringenin, alone or combined with minoxidil, significantly increased hair growth and follicle diameter and quantity, likely due to its antioxidant and anti-inflammatory properties.
November 2023 in “Journal of medical and health studies” In this study, combining low-level laser therapy with microneedling showed statistically significant improvement in hair growth for three adult patients with androgenetic alopecia over three months, suggesting it may be a promising management approach.
July 2023 in “International journal of advanced research in medical and pharmaceutical sciences” In this study, researchers formulated and evaluated a gel containing minoxidil and aloe vera for alopecia treatment, finding that it was stable and non-irritant on albino rats, suggesting enhanced topical drug delivery over traditional solutions.
June 2023 in “jurnal veteriner” In this study, Typhonium flagelliforme leaf-ethanolic extract combined with natural interferon was observed to stabilize body weight, inhibit tumor growth, and reduce mitosis, angiogenesis, and certain protein expressions in carcinogen-induced tumors in female mice, suggesting potential antitumor effects.
June 2023 in “Deleted Journal” In this study, combining pemetrexed with cisplatin in non-small cell lung cancer patients improved immune function and had lower blood toxicity compared to cisplatin with gemcitabine, despite similar disease control rates and other side effects between the two treatment groups.
June 2023 in “Dermatology and Therapy” This study found that for patients with moderate-to-severe chronic hand eczema, combining fractional CO2 laser with halometasone cream was more effective than using halometasone cream alone, with a higher treatment success rate and fewer relapses, though skin pigmentation was a common side effect.
June 2023 in “Journal of Cosmetic Dermatology” This study found that a combination therapy of autologous platelet-rich plasma and non-cross-linked hyaluronic acid increased hair density significantly in women with female androgenetic alopecia, without serious adverse effects.
May 2023 in “Journal of Cosmetic Dermatology” This prospective randomized controlled trial found that combining platelet-rich plasma plus basic fibroblast growth factor injections with topical minoxidil significantly improves hair count and growth rate in androgenetic alopecia patients compared to either treatment alone.
May 2023 in “Jurnal farmasi sains dan praktis” In this research on cinnamon and virgin coconut oil hair tonics, F2 and F3 demonstrated stable physical properties and mild irritation potential, while formula 1 remained non-irritating but less stable regarding pH and viscosity.
April 2023 in “Journal of Investigative Dermatology” This review discusses randomized trials on PRP and laser therapy for vitiligo, acne scars, and skin rejuvenation, finding combination therapy may yield clinical improvements but calls for more diverse studies.
In this study, the combined treatment of ursolic acid and resveratrol was evaluated for its effects on skin tumor promotion in female FVB mice. The combination was applied topically before TPA treatment and was found to significantly inhibit TPA-induced epidermal hyperproliferation, signaling pathways, and skin inflammation more effectively than either compound alone. Key signaling pathways affected included EGFR, STAT3, and NF-κB, among others. The combination also increased tumor suppressor levels and reduced proinflammatory cytokine expression. Overall, the combined treatment resulted in a greater reduction in tumor multiplicity and size, highlighting its potential as a more effective strategy for inhibiting skin tumor promotion compared to individual treatments.
In this study, the combined treatment of ursolic acid and resveratrol was evaluated for its inhibitory effects on skin tumor promotion in female FVB mice. The combination was applied topically before TPA treatment and was found to significantly inhibit TPA-induced epidermal hyperproliferation, signaling pathways, and skin inflammation more effectively than either compound alone. Key signaling pathways affected included EGFR, STAT3, and NF-κB, among others. The combination also increased tumor suppressor levels and reduced proinflammatory cytokine expression. Overall, the combined treatment resulted in a greater reduction in tumor multiplicity and size, highlighting its potential as a more effective strategy for preventing skin tumor promotion compared to individual treatments.
March 2023 in “International Journal of Trichology” This study found that a combination of topical 5% minoxidil and 0.25% finasteride was more effective at improving hair density and satisfaction in men with androgenetic alopecia than either treatment alone over 24 weeks.
January 2023 in “Journal of cosmetic dermatology” This study concluded that fractional laser therapy, alone or combined with minoxidil or cortisol, effectively treated alopecia areata, showing better outcomes than the drugs alone, without increasing adverse effects, though effectiveness did not significantly differ from similar physical treatments.