September 2017 in “Journal of Investigative Dermatology” This study suggests that sweat glands may have an immune privilege similar to hair follicles, and disruptions in this could contribute to autoimmune skin diseases.
January 2017 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that oral collagen peptides increased the expression of genes related to epidermal and hair cycle development in hairless mouse skin.
This study found that oral collagen peptides increased expression of genes associated with epidermis development and the hair cycle in hairless mice, providing insights into their potential skin benefits.
September 2016 in “Journal of dermatological science” This study found that COL17 plays a key role in regulating epidermal keratinocyte differentiation and proliferation, influencing the expression of differentiation markers and cellular growth in specific conditions.
July 2016 in “Cancer Research” This study developed a topical botanical lotion for managing chemotherapy-induced hair loss in cancer patients, reporting that it improved hair recovery times by 5-16 weeks, reduced inflammation, and enhanced scalp collagen levels with no observed side effects.
April 2016 in “Journal of The American Academy of Dermatology” A botanical lotion can increase scalp collagen and extend hair growth phase, potentially improving hair thinning issues.
March 2016 in “Institutional Repositories DataBase (IRDB)” This study discusses the effects of collagen hydrolysates and the dipeptide Pro-Hyp on gene expression related to hair and epidermis development in mouse skin and reports no new clinical results.
March 2016 in “Benha Veterinary Medical Journal” This study investigated the gene Col19a1, finding its expression is specific to certain cells during hair follicle development in mice, suggesting its potential role in hair follicle morphogenesis.
January 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study demonstrates that collagen XVII is crucial for normal glomerular development, is present in normal colon epithelia, and plays a role in carcinogenesis in colorectal and squamous cell cancers.
This study found that collagen VI is crucial for peripheral nerve function and regeneration, and its absence promotes abnormal hair regrowth after skin wounding in mice, revealing potential therapeutic targets for nerve injuries and hair loss.
January 2015 in “Zhongguo haiyang yaowu” This study found that collagen oligopeptides from puffer skin may reduce skin melanin and increase hydroxyproline content in guinea pigs, suggesting potential skin whitening and anti-aging effects.
January 2015 in “Journal of clinical & experimental dermatology research” This study found that treatment with PTH-CBD stimulated hair growth in mice with alopecia areata, with increased levels of beta catenin indicating activation of the Wnt pathway.
March 2012 in “Daehan hwajangpum hakoeji/Daehan hwa'jangpum haghoeji” This study observed that a cream containing functional compounds from medicinal plants increased collagen production in human skin, while a hair tonic enhanced hair growth in mice.
January 2010 in “Pharmacy Today” This study found that collagen and its compound may have antioxidant effects and reduce melanin in guinea pigs, while increasing skin moisture and hydroxyproline content in mice.
January 2006 in “Journal of Sun Yat-sen University” This study reports that tissue-engineered skin using ES cell-derived epidermal stem cells and collagen sponge successfully healed full thickness skin defects in mice, forming epidermis and structures resembling glands and hair follicles.
January 2006 in “Chinese Journal of Dermatology” In this study, researchers found that hair follicle-like structures can be generated from collagen/chitosan porous scaffolds implanted with mouse hair follicle cells in vitro.
January 2005 in “China Surfactant Detergent & Cosmetics” This study found that applying black mud to mice increased skin collagen and superoxide dismutase activity, decreased malondialdehyde levels, and enhanced hair growth and smoothness.
January 2005 in “Medical Entomology and Zoology” The reinforced collagen sponge helps grow normal hair in mice.
This study found that a skin-like structure can be generated in vitro by implanting early passage hair follicle bulb cells into collagen/chitosan porous scaffolds.
Collagen gel contraction in hair follicle culture is mainly influenced by the amounts of collagen, dermal papilla cells, and epithelium cells.
January 2003 in “Jiepouxue zazhi” This study found that human hair keratin can serve as a matrix for skin structure restoration, as observed in rats where the graft was replaced by newly formed collagenous fibers over six weeks.
January 1994 in “Nihon Chikusan Gakkaiho” This study observed that mink dermal collagen fibrils undergo structural changes during the hair cycle, with increased fiber thickness and bundle density as minks grow.
In this study, autotransplanted interfollicular epidermis keratinocytes in a collagen dermis framework formed follicular-like structures, but their proliferation ceased after 15-20 days.
Collagen CLR and placenta extract may help treat diffuse hair loss.
June 2021 in “Journal of Cosmetic Dermatology” Laser treatment shows promise for hair growth, but needs further research.
September 2025 in “International Journal of Biological Macromolecules” In an animal study with a skin defect model, this research reported that curcumin-loaded hydrogels made from recombinant humanized collagen and an eco-friendly crosslinker enhanced wound repair by promoting angiogenesis, granulation tissue formation, and hair follicle neogenesis, while providing antioxidant benefits.
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April 2020 in “Nutrafoods - International Journal on Nutraceuticals, Functional Foods and Novel Foods” In this study, Bioactive Collagen Peptides supplementation increased hair follicle cell proliferation and improved hair thickness in healthy women over 16 weeks compared to a placebo.
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January 2025 in “PubMed” This study compared the effectiveness of different thread types in improving collagen profiles in UVB-exposed aging model rats, finding that PCL threads were more effective than PDO and PLLA in enhancing dermal collagen characteristics.
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March 2022 in “International Journal of Trichology” This study found that nutritional supplementation with hydrolyzed collagen, amino acids, vitamins, and minerals significantly improved hair anagen/telogen ratios and hair density in telogen effluvium patients.
July 2026 in “ACS Pharmacology & Translational Science” This source provides a review of patents on the use of fish collagen peptides in wound care, highlighting benefits like skin hydration, scar repair, and antiaging, while emphasizing the need for further clinical research to validate these applications.