14 citations
,
April 2017 in “Scientific Reports” This study demonstrated that using a perfusion culture bioreactor and 3D spheroid culture can enhance corneal endothelial cell expansion and support the construction of tissue-engineered corneal endothelial layers in vitro.
This study used an ex vivo human skin model to show that tropical conditions disrupt skin homeostasis, resulting in epidermal thickening and junctional flattening, and found that Kombucha tea extract may help preserve skin structure under such stress.
July 2023 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, researchers analyzed skin tumors from patients with CYLD cutaneous syndrome and found that loss of CYLD function is linked to changes in cellular signaling pathways, particularly NF-κB signaling, and leads to increased secretion of specific extracellular matrix proteins.
19 citations
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March 2017 in “PLoS ONE” This study found that intact pilosebaceous units were more effective than truncated hair follicles at regenerating a multilayered epidermis in a de-epidermalized dermis in vitro.
6 citations
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January 2024 in “Frontiers in Bioengineering and Biotechnology” This study developed a smart PVA-TPE/HA-AMP/SF/ALG wound dressing that shows promise in infected wound healing by providing bacterial resistance, promoting cell proliferation, and modulating inflammation through various signaling pathways, potentially reducing scar formation.
December 2025 in “Frontiers in Nutrition” This review suggests that although hydrolyzed collagen peptides with certain supplements may improve skin elasticity and joint function, evidence for collagen's anti-aging and regenerative benefits remains inconsistent.
106 citations
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April 1986 in “British Journal of Dermatology” This study found that dermal papilla cells from human hair follicles form multi-layered aggregates when cultured in vitro, contrasting with the monolayer growth of dermal fibroblasts.
60 citations
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April 2003 in “Biomaterials” This study found that the controlled release of specific growth factors from biodegradable hydrogels significantly enhanced hair follicle growth and hair shaft length in mice compared to growth factors in solution.
52 citations
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October 2005 in “Journal of Investigative Dermatology” This study found that human hair follicle stem cells formed more colonies and adhered more rapidly, while transit-amplifying cells showed significantly greater mobility.
28 citations
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June 2020 in “ACS Biomaterials Science & Engineering” This study found that a novel ECM patch combining human fibroblast-derived matrix and PVA hydrogel, seeded with human mesenchymal stem cells, significantly improved wound healing and tissue regeneration in a mouse model.
25 citations
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August 1992 in “In vitro cellular & developmental biology” The new system can grow hair in the lab and test hair growth treatments.
24 citations
,
January 1989 This research discusses the function and culture of human dermal papilla cells, noting their unique in vitro characteristics and the ongoing efforts to understand their role in inducing hair growth.
21 citations
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December 1994 in “British Journal of Dermatology” In this study, cultured skin equivalents with ovine hair follicle dermal papillae grafted onto nude mice developed follicle-like structures, suggesting a potential model for studying hair follicle development.
16 citations
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February 2005 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that VDR deficiency in mice leads to various skin pathologies but does not affect the phenotype or function of Langerhans cells.
13 citations
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August 2007 in “Journal of Investigative Dermatology” Mouse hair can regrow in a special lab setup without serum.
12 citations
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July 1993 in “In Vitro Cellular & Developmental Biology - Animal” Minoxidil enhances hair growth and preserves the root sheath in cultured follicles.
11 citations
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January 2018 in “IET Nanobiotechnology” In this study, poly (ɛ-caprolactone)–chitosan–poly (vinyl alcohol) nanofibrous scaffolds used on canine skin wound models were found to significantly accelerate healing rates of excision and burn wounds, without inducing immunogenic reactions.
10 citations
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February 2014 in “Fitoterapia” This study found that Pomiferin may effectively stimulate extracellular matrix protein expression in skin and scalp models, with results comparable to retinol, suggesting potential as a topical treatment ingredient.
8 citations
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November 2020 in “Skin Research and Technology” This study found that enlarged facial pores in women show distinct microstructural alterations, including regular keratinocyte arrangement and irregular dermo-epidermal junctions, highlighting changes in skin tension linked to pore enlargement.
1 citations
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January 2023 in “Journal of research in pharmacy” This study found that the methanolic extract of Carduus adpressus exhibited strong antibacterial, antioxidant, and wound-healing activities, suggesting its potential use in developing wound-healing agents.
January 2015 in “Journal of clinical & experimental dermatology research” This study found that treatment with PTH-CBD stimulated hair growth in mice with alopecia areata, with increased levels of beta catenin indicating activation of the Wnt pathway.
October 2024 in “Acta Biomaterialia” This study introduced a novel method that uses upright structured illumination microscopy and atomic force microscopy to map the mechanical properties of thick living tissue slices, revealing the intricate mechanical heterogeneity of mouse skin and effects of preservation techniques on tissue stiffness.
July 2024 in “DOAJ (DOAJ: Directory of Open Access Journals)” This article reviews the effects of vitamins, including A, C, D, E, and B, on animal fur, highlighting their roles in promoting healthy skin and fur condition by regulating cell renewal, metabolism, and collagen synthesis.
April 2024 in “UNESP Institutional Repository (São Paulo State University)” In this study, researchers analyzed alpaca skin morphology and found that type I and IV collagen are present in both the epidermis and dermis, while type III collagen is found only in the dermis.
January 2007 in “동물실험대체법학회지” This article reviews in vitro methods for evaluating whitening, anti-wrinkle, and hair growth ingredients in cosmetics, noting that more human-relevant evaluation methods with reliable biomarkers are needed; it presents no new clinical outcomes.
January 2006 in “Chinese Journal of Dermatology” In this study, researchers found that hair follicle-like structures can be generated from collagen/chitosan porous scaffolds implanted with mouse hair follicle cells in vitro.
September 2004 in “Experimental Dermatology” This study developed a tissue-engineered model of innervated skin, allowing for examination of how epidermis and capillaries affect nerve growth and offering a tool for further research on skin-related processes.
This study found that culturing hair follicles at the air-liquid interface enhanced hair growth and maintained an anagen-like morphology better than submerged cultures.
10 citations
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January 2024 in “Dermatology Research and Practice” This randomized, double-blind, placebo-controlled study found that a supplement containing hydrolysed collagen and vitamin C (Absolute Collagen) improved skin, scalp, and hair over 12 weeks when taken daily or every other day.
March 2024 in “Clinical, cosmetic and investigational dermatology” This study found that in healthy adult women, a collagen and antioxidant-rich treatment significantly improved skin elasticity, hydration, texture, and reduced wrinkles and hair fall over 56 days compared to a placebo, indicating its efficacy and safety.