22 citations
,
February 2013 in “Wound Repair and Regeneration” In this study, CD109 overexpression in transgenic mice led to reduced inflammation and improved collagen organization during wound healing without affecting wound closure.
20 citations
,
January 2008 in “Journal of Korean Medical Science” This study found that NGAL expression increased in calcium-induced keratinocyte differentiation in vitro and was highly elevated in psoriasis-like skin conditions and skin cancers, suggesting a role in skin hyperplasia and homeostasis.
15 citations
,
January 2003 in “Lasers in Surgery and Medicine” This study found that cold air can effectively preserve the epidermis when using an 810 nm diode laser, but it is slightly less effective than a chilled sapphire window in dark-haired pigmented pigs.
13 citations
,
January 2017 in “Plastic and reconstructive surgery. Global open” This study found that Juvéderm Ultra Plus was safe and effective for correcting severe nasolabial folds in a Chinese population, requiring less volume than Restylane while achieving similar responder rates, with fewer severe treatment site reactions.
11 citations
,
April 2020 in “Nutrafoods - International Journal on Nutraceuticals, Functional Foods and Novel Foods” In this study, Bioactive Collagen Peptides supplementation increased hair follicle cell proliferation and improved hair thickness in healthy women over 16 weeks compared to a placebo.
10 citations
,
May 2020 in “Clinical and Experimental Health Sciences” This study found that Tideglusib at 50nM stimulated Type-I collagen production in human gingival fibroblasts and osteoblasts, suggesting potential benefits for bone regeneration.
9 citations
,
August 2024 in “Tissue Engineering and Regenerative Medicine” In this study, researchers suggest that strategic early intervention during fetal wound healing could lead to significantly improved long-term skin regeneration outcomes.
9 citations
,
January 2022 in “Theranostics” This review discusses the role of collagen XVII in maintaining stem cell niches and its impact on skin aging and wound repair, without reporting new clinical results.
8 citations
,
April 2014 in “Anti-Cancer Drugs” In this study, PTH–CBD displayed dose-dependent effects in reducing hair loss and enhancing hair regrowth in a mouse model of chemotherapy-induced alopecia.
3 citations
,
June 2017 in “Aesthetic plastic surgery” This study reported that novel adipose slurry injections improved rhytides and dermis density in patients receiving facial wrinkle treatments based on evaluations at multiple follow-up intervals.
2 citations
,
September 2010 in “Journal of the Korea Academia-Industrial cooperation Society” This study found that increasing collagen concentration to 2% in permanent wave treatments reduced hair damage but impaired curl formation.
December 2025 in “Frontiers in Nutrition” This review suggests that although hydrolyzed collagen peptides with certain supplements may improve skin elasticity and joint function, evidence for collagen's anti-aging and regenerative benefits remains inconsistent.
July 2025 in “Scientific Reports” In this study, peptide nanofiber gels RG and RJ significantly accelerated the healing of deep second-degree burn wounds in vivo, with greater wound closure rates and enhanced tissue regeneration compared to controls, attributed to increased angiogenesis and reduced systemic inflammation.
February 2024 in “Research Square (Research Square)” In this study, researchers applied Strat-M® membrane to assess the in vitro transdermal properties of collagen peptides, finding a high correlation with results from mouse skin and suggesting that Strat-M® can effectively replace excised mouse skin in transdermal experiments.
January 2015 in “Journal of clinical & experimental dermatology research” This study found that treatment with PTH-CBD stimulated hair growth in mice with alopecia areata, with increased levels of beta catenin indicating activation of the Wnt pathway.
November 2025 in “Quality in Sport” This review found that hydrolyzed collagen supplementation, particularly marine collagen, improves skin hydration, elasticity, and density while strengthening hair and nails, especially when paired with vitamin C and trace elements; however, more studies are necessary to evaluate long-term efficacy across different sources and demographics.
September 2023 in “Journal of microbiology and biotechnology” This study found that low molecular weight collagen peptide from fish may promote hair growth in both human cells and mice by activating the Wnt/β-catenin signaling pathway.
September 2016 in “Journal of dermatological science” This study found that COL17 plays a key role in regulating epidermal keratinocyte differentiation and proliferation, influencing the expression of differentiation markers and cellular growth in specific conditions.
March 2016 in “Institutional Repositories DataBase (IRDB)” This study discusses the effects of collagen hydrolysates and the dipeptide Pro-Hyp on gene expression related to hair and epidermis development in mouse skin and reports no new clinical results.
January 2007 in “Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)” This study concluded that keratin-gelatin composite films were more effective than bFGF-gelatin films in promoting early and uncomplicated wound healing in dogs, observing improved epithelialization and graft acceptance.
57 citations
,
September 2017 in “Journal of controlled release” This review discusses recent advances in using nanocarrier-loaded gels for various medical applications and reports no new clinical results, highlighting potential advantages in therapeutic strategies.
45 citations
,
October 2014 in “Stem cell research & therapy” This study found that using 3D Gel-C6S-HA scaffolds seeded with VEGF165-modified rat hair follicle stem cells enhanced angiogenesis and vascularization in tissue-engineered skin, improving wound healing.
10 citations
,
January 2022 in “Scholars international journal of anatomy and physiology” This review discusses Aloe Vera's traditional uses and active components but reports no new clinical results, emphasizing its potential benefits from wound healing to hair growth.
5 citations
,
March 2019 in “Scientific Reports” This study reports that the side population technique can isolate melanocyte stem cells from human hair follicles, potentially allowing them to be used for skin pigmentation repopulation.
5 citations
,
September 2015 in “PLoS ONE” This study demonstrated that Gelfoam® histoculture supports extensive growth of both hair shafts and sensory nerves from isolated mouse whisker follicles over prolonged periods.
4 citations
,
January 2025 in “Journal of Materials Chemistry B” In this study, researchers developed a multifunctional, injectable hydrogel that adapts to irregularly shaped wounds, enhances healing, and shows potential antibacterial activity without significant toxicity, suggesting promise for treating chronic wounds.
1 citations
,
December 2023 in “Egyptian Journal of Veterinary Science” In this study, researchers found that a nanoparticle gel derived from Astragalus polysaccharides improved wound healing significantly more than a Gold-Silver nanocomposite gel and untreated controls, with better wound closure observed by the 15th day.
September 2023 in “Çukurova medical journal (Online)/Çukurova medical journal” This study observed that EZH2 expression scores in the epidermis, dermis, and hair follicles decrease with gestational age in human fetuses, and these scores were significantly higher in adults, indicating that lower EZH2 levels may be required for full skin differentiation and maturation before birth.
3 citations
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October 2021 in “PLoS ONE” In this study, topical piperonylic acid was found to improve wound healing in mice by activating EGFR and modulating gene expression related to the healing process.
1 citations
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January 2021 in “Wiadomości Lekarskie” This experimental study on male rats found that a gel containing carbon dioxide extract of hops effectively promoted wound healing in severe acne by enhancing skin regeneration and exhibiting anti-inflammatory, bactericidal, and antimycotic properties.